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1. (WO2019067413) UTILISATION D'UNE FORMULATION DE FENFLURAMINE POUR RÉDUIRE LE NOMBRE ET LES FRÉQUENCES DE CRISES CONVULSIVES DANS DES POPULATIONS DE PATIENTS



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2018/052580 ZGNX-170WO
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
25 September 2018 26 September 2017
Applicant
ZOGENIX INTERNATIONAL LIMITED
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No.     1    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61K 31/137 (2006.01)i; A61P 25/08 (2006.01)i; A61K 45/06 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61K; A61P
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, BIOSIS, CHEM ABS Data, EMBASE, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
US 2014329908 A1 (CEULEMENS BERTEN [BE] ET AL) 06 November 2014 (2014-11-06)
1-8,13-15
Y
paragraphs [0053], [0054], [0064] - [0065]; claims 1, 5, 19; example 1
1-15
(2)
X
US 2017071949 A1 (DE WITTE PETER [BE] ET AL) 16 March 2017 (2017-03-16)
1-8,13-15
Y
abstract; claims 1, 17-19
1-15
paragraphs [0126], [0202], [0251] - [0253]
(3)
X
M. BOEL ET AL, "Add-On Therapy of Fenfluramine in Intractable Self-Induced Epilepsy", NEUROPEDIATRICS,Vol. 27, No. 04, 01 August 1996 (1996-08-01), page 171-173,
XP055565166
1-8,13-15
Y
the whole document
9-12
(4)
X
BERTEN CEULEMANS ET AL, "Successful use of fenfluramine as an add-on treatment for Dravet syndrome", EPILEPSIA,Vol. 53, No. 7, 03 May 2012 (2012-05-03), page 1131-1139,
XP055123152
1-8,13-15
Y
the whole document
9-12
(5)
X
A. SCHOONJANS ET AL, "Low-dose fenfluramine significantly reduces seizure frequency in Dravet syndrome: a prospective study of a new cohort of patients", EUROPEAN JOURNAL OF NEUROLOGY,Vol. 24, No. 2, 28 October 2016 (2016-10-28), page 309-314,
XP055535755
1-8,13-15
Y
the whole document
9-12
(6)
X
MUDIGOUDAR BASANAGOUD ET AL, "Emerging Antiepileptic Drugs for Severe Pediatric Epilepsies", SEMINARS IN PEDIATRIC NEUROLOGY, SAUNDERS, PHILADELPHIA, PA, US,Vol. 23, No. 2, 04 June 2016 (2016-06-04), page 167-179,
XP029689530
1-8,13-15
Y
the whole document
9-12
(7)
Y
US 2015359755 A1 (GUY GEOFFREY [GB] ET AL) 17 December 2015 (2015-12-17)
9,10
abstract; claims 1-13
(8)
Y
Zogenix, "Corporate Update NASDAQ: ZGNX", 01 June 2016 (2016-06-01),
Retrieved from the Internet:
URL:http://www.jefferies.com/CMSFiles/Jefferies.com/files/Conferences/060716/Presentations/Zogenix%20Inc.pdf
XP055453140
[retrieved on  2018-02-21]
1-15
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
US 2014329908 A1
06 November 2014
AU 2014261329 A1
BR 112015027282 A2
CA 2909335 A1
DK 2991637 T3
EP 2991637 A1
EP 3329909 A1
ES 2666657 T3
JP 6441313 B2
JP 2016518387 A
PL 2991637 T3
PT 2991637 T
US 2014329908 A1
US 2014343044 A1
US 2014343161 A1
US 2014343162 A1
US 2016136114 A1
US 2017151194 A1
US 2017151213 A1
US 2017151214 A1
US 2017151257 A1
US 2017151259 A1
WO 2014177676 A1
05 November 2015
25 July 2017
06 November 2014
07 May 2018
09 March 2016
06 June 2018
07 May 2018
19 December 2018
23 June 2016
31 July 2018
24 April 2018
06 November 2014
20 November 2014
20 November 2014
20 November 2014
19 May 2016
01 June 2017
01 June 2017
01 June 2017
01 June 2017
01 June 2017
06 November 2014
US 2017071949 A1
16 March 2017
US 2017071949 A1
US 2018325909 A1
16 March 2017
15 November 2018
US 2015359755 A1
17 December 2015
AU 2015275886 A1
AU 2015275887 A1
BR 112016029498 A2
BR 112016029506 A2
CA 2952858 A1
CA 2952994 A1
EP 3157511 A1
EP 3157512 A1
ES 2680656 T3
ES 2680679 T3
GB 2530001 A
GB 2531093 A
JP 2017519758 A
JP 2017524672 A
PL 3157511 T3
PL 3157512 T3
US 2015359755 A1
US 2015359756 A1
US 2017172939 A1
US 2017172940 A1
US 2017173043 A1
US 2017173044 A1
US 2017181982 A1
US 2017246121 A1
US 2018338931 A1
WO 2015193667 A1
WO 2015193668 A1
12 January 2017
12 January 2017
22 August 2017
22 August 2017
23 December 2015
23 December 2015
26 April 2017
26 April 2017
10 September 2018
10 September 2018
16 March 2016
13 April 2016
20 July 2017
31 August 2017
28 February 2019
28 February 2019
17 December 2015
17 December 2015
22 June 2017
22 June 2017
22 June 2017
22 June 2017
29 June 2017
31 August 2017
29 November 2018
23 December 2015
23 December 2015
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
11 March 2019
Date of mailing of the international search report:
20 March 2019
Authorized officer:
Ansaldo, M
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