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International application No. Applicant's or agent's file reference
PCT/US2018/048878 PIR-001WO
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
30 August 2018 30 August 2017
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
This international search report has not been established in respect of certain claims under Article 17(2)(a) for the following reasons:
Claims Nos.: 25-38
because they relate to subject matter not required to be searched by this Authority, namely:
Rule 39.1(iv)  PCT - Method for treatment of the human or animal body by therapy
Claims Nos.:
because they relate to parts of the international application that do not comply with the prescribed requirements to such an extent that no meaningful international search can be carried out, specifically:
Claims Nos.:
because they are dependent claims and are not drafted in accordance with the second and third sentences of Rule 6.4(a).
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
The figure of the drawings to be published with the abstract is Figure No.     5    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
none of the figures is to be published with the abstract.


     A61M 5/20 (2006.01)i; A61M 5/142 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC


Minimum documentation searched (classification system followed by classification symbols):
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data


Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
WO 2017004315 A1 (VALERITAS INC [US]) 05 January 2017 (2017-01-05)
the whole document
WO 2015117913 A1 (SANOFI SA [FR]) 13 August 2015 (2015-08-13)
the whole document
US 2016082189 A1 (ANDERSON PHILIP D [US] ET AL) 24 March 2016 (2016-03-24)
the whole document
Special categories of cited documents:
document defining the general state of the art which is not considered to be of particular relevance
earlier application or patent but published on or after the international filing date
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
document referring to an oral disclosure, use, exhibition or other means
document published prior to the international filing date but later than the priority date claimed
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
document member of the same patent family


Patent document cited in search report Publication date
Patent family member(s) Publication date
WO 2017004315 A1
05 January 2017
AU 2016287632 A1
AU 2018247266 A1
CA 2990453 A1
CN 107921214 A
EP 3316940 A1
JP 2018519048 A
US 2018193557 A1
WO 2017004315 A1
18 January 2018
01 November 2018
05 January 2017
17 April 2018
09 May 2018
19 July 2018
12 July 2018
05 January 2017
WO 2015117913 A1
13 August 2015
CN 106132463 A
EP 3102264 A1
JP 2017505180 A
US 2017165418 A1
WO 2015117913 A1
16 November 2016
14 December 2016
16 February 2017
15 June 2017
13 August 2015
US 2016082189 A1
24 March 2016
AU 2011242602 A1
BR 112012026886 A2
CA 2796186 A1
CN 103118737 A
CN 104906656 A
EP 2560727 A1
EP 3360596 A1
JP 5809242 B2
JP 6189903 B2
JP 2013524951 A
JP 2016025924 A
JP 2017225828 A
KR 20130092418 A
KR 20160150645 A
KR 20180041261 A
MX 339532 B
NZ 602782 A
NZ 702172 A
RU 2012149446 A
SG 184934 A1
SG 10201503130U A
US 2012022499 A1
US 2016082189 A1
US 2018154079 A1
WO 2011133823 A1
25 October 2012
13 September 2016
27 October 2011
22 May 2013
16 September 2015
27 February 2013
15 August 2018
10 November 2015
30 August 2017
20 June 2013
12 February 2016
28 December 2017
20 August 2013
30 December 2016
23 April 2018
30 May 2016
31 July 2015
31 March 2016
27 May 2014
29 November 2012
29 June 2015
26 January 2012
24 March 2016
07 June 2018
27 October 2011
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
07 November 2018
Date of mailing of the international search report:
15 November 2018
Authorized officer:
Neiller, Frédéric
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