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1. (WO2019043647) SYSTÈMES ET PROCÉDÉS METTANT EN ŒUVRE UN MÉLANGE GAZEUX POUR SÉLECTIONNER DES IONS
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

CLAIMS

1. A system configured to permit switching of a cell between at least two modes comprising a collision mode and a reaction mode to select ions received by the cell, the system comprising: a cell configured to receive a gas mixture comprising a binary gas mixture in the collision mode to pressurize the cell and configured to receive the same gas mixture comprising the binary gas mixture in the reaction mode to pressurize the cell; and

a processor electrically coupled to the cell, the processor configured to provide a voltage to the pressurized cell comprising the gas mixture in the collision mode to facilitate the transmission of select ions with an energy greater than an energy barrier induced by the provided first voltage, wherein the processor is further configured to provide a second voltage to the pressurized cell comprising the gas mixture in the reaction mode to guide select ions into a mass filter fluidically coupled to the cell.

2. The system of claim 1, in which the processor is further configured to permit switching of the cell to a vented mode.

3. The system of claim 1, in which the system further comprises a single gas inlet fluidically coupled to the cell to provide the gas mixture comprising the binary gas mixture.

4. The system of claim 3, in which the cell comprises a multipole rod set comprising of 2, 4, 6, 8, or 10 rods.

5. The system of claim 4, in which the cell further comprises an exit member positioned proximate to an exit aperture of the cell and electrically coupled to a voltage source, the exit member configured to direct analyte ions in the pressurized cell toward the exit aperture of the cell.

6. The system of claim 5, in which the exit member can be set at a voltage between -60 Volts and +20 Volts in the collision mode of the pressurized cell.

7. The system of claim 5, in which the exit member can be set at a voltage between -60 Volts and +20 Volts in the reaction mode of the pressurized cell.

8. The system of claim 5, in which the cell further comprises an entrance member positioned proximate to an entrance aperture of the cell and electrically coupled to a voltage source, the entrance member configured to direct analyte ions into the pressurized cell toward the entrance aperture of the cell.

9. The system of claim 8, in which the entrance member can be set at a voltage between -60 Volts and +20 Volts in the collision mode of the pressurized cell.

10. The system of claim 8, in which the entrance member can be set at a voltage substantially similar to a voltage provided to the exit member when the pressurized cell is in the reaction mode.

11. The system of claim 1, in which the cell is configured to switch from the collision mode to the reaction mode while maintaining the same gas flow or changing to a different flow level by switching the voltages on the entrance member and exit member and optionally changing the energy barrier between the cell and the mass analyzer.

12. The system of claim 1, in which the cell is configured to switch from the reaction mode to the collision mode while maintaining the same gas flow or changing to a different flow level by switching the voltages on the entrance member and the exit member and optionally changing the energy barrier between the cell and the mass analyzer.

13. The system of claim 1, further comprising axial electrodes electrically coupled to a voltage source and configured to provide an axial field to direct ions toward an exit aperture of the pressurized cell.

14. The system of claim 13, in which the axial field comprises a field gradient between -500 V/cm and 500 V/cm.

15. The system of claim 1, in which the processor is further configured to provide an offset voltage to the pressurized cell.

16. The system of claim 15, further comprising a mass analyzer fluidically coupled to the cell comprising the offset voltage.

17. The system of claim 16, in which an offset voltage of the fluidically coupled mass analyzer is more positive than the offset voltage of the cell when the cell is in the collision mode.

18. The system of claim 16, in which an offset voltage of the fluidically coupled mass analyzer is more negative than the offset voltage of the cell when the cell is in the reaction mode.

19. The system of claim 16, further comprising an ionization source fluidically coupled to the cell.

20. The system of claim 1, in which the cell is configured to use a binary mixture of helium gas and hydrogen gas in the collision mode and in the reaction mode.

21. A mass spectrometer system comprising:

an ion source;

a cell fluidically coupled to the ion source and configured to operate in at least three different modes comprising a collision mode, a reaction mode and a standard mode, the three different modes each configured to select analyte ions from a plurality of ions received into the cell from the ion source, the cell configured to couple to the ion source at an entrance aperture to permit receipt of the plurality of ions from the ion source, the cell comprising a gas inlet configured to receive a gas mixture comprising a binary gas mixture in the collision mode to pressurize the cell in the collision mode, wherein the cell is configured to receive the gas mixture comprising the binary gas mixture in the reaction mode to pressurize the cell in the reaction mode, the cell further comprising an exit aperture configured to provide the analyte ions from the cell; and

a mass analyzer fluidically coupled to the cell; and

a processor electrically coupled to the cell, the processor configured to provide the gas mixture to the cell in each of the collision mode and the reaction mode and to maintain the cell under vacuum in the standard mode.

22. The system of claim 21, in which the cell comprises a multipole rod set comprising of 2, 4, 6, 8, or 10 rods.

23. The system of claim 22, in which the processor is configured to provide a first voltage to the pressurized cell comprising the gas mixture in the collision mode to select ions comprising an energy greater than a selected barrier energy.

24. The system of claim 23, wherein the processor is configured to provide a second voltage to the pressurized cell comprising the gas mixture in the reaction mode to select ions using mass filtering.

25. The system of claim 24, further comprising axial electrodes configured to provide an axial field to direct the analyte ions from the entrance aperture toward an exit aperture of the pressurized cell.

26. The system of claim 25, in which the axial field strength comprises an axial field gradient between -500 V/cm and +500 V/cm.

27. The system of claim 25, further comprising an exit member positioned proximate to an exit aperture of the pressurized cell, the exit member comprising an exit potential to attract analyte ions toward the exit aperture of the pressurized cell.

28. The system of claim 27, in which the exit member comprises a voltage between -26 Volts and +26 Volts in the collision mode of the pressurized cell.

29. The system of claim 27, in which the exit member comprises a voltage between -26 Volts and +26 Volts in the reaction mode of the pressurized cell.

30. The system of claim 27, further comprising an entrance member positioned proximate to an entrance aperture of the pressurized cell, the entrance member comprising an entrance potential more positive than the exit potential in the collision mode.

31. The system of claim 30, in which the entrance potential is between -40 Volts and +10 Volts.

32. The system of claim 27, further comprising an entrance member positioned proximate to an entrance aperture of the pressurized cell, the entrance member comprising an entrance potential substantially similar to the exit potential in the reaction mode.

33. The system of claim 32, in which the exit potential is between -40 Volts and +10 Volts in the collision mode.

34. The system of claim 32, in which the exit potential is between -40 Volts and +10 Volts in the reaction mode.

35. The system of claim 21, further comprising an ion deflector positioned between the ion source and the cell.

36. The system of claim 35, further comprising a detector fluidically coupled to the cell.

37. The system of claim 36, in which the detector comprises an electron multiplier.

38. The system of claim 37, in which the ion source is configured as an inductively coupled plasma.

39. The system of claim 38, further comprising an interface positioned between the inductively coupled plasma and the mass analyzer.

40. The system of claim 39, further comprising a fluid line configured to introduce the gas mixture comprising the binary gas mixture into the interface.

41. A method of selecting ions using a mass spectrometer, the method comprising:

providing an ion stream comprising a plurality of ions from an ion source into a pressurized cell configured to operate in a reaction mode and in a collision mode using a gas mixture comprising a binary gas mixture, wherein the gas mixture is introduced into the cell in each of the reaction mode and the collision mode of the cell to pressurize the cell; and

selecting ions, from the plurality of ions in the pressurized cell comprising the gas mixture, that comprise an energy greater than a selected barrier energy when the cell is in the collision mode, and selecting ions, from the plurality of ions in the ion stream provided to the pressurized cell comprising the gas mixture, using mass filtering when the cell is in the reaction mode.

42. The method of claim 41, further comprising configuring the cell as a multipole rod cell.

43. The method of claim 42, further comprising providing an exit barrier at an exit aperture of the pressurized cell by providing a potential to an exit member positioned proximate to the exit aperture.

44. The method of claim 43, further comprising providing a potential to an entrance member positioned proximate to an entrance aperture of the cell, the potential provided to the entrance member configured to focus the plurality of ions received by the cell from the ion source upstream of a rod set of the cell.

45. The method of claim 41, further comprising configuring the gas mixture to comprise hydrogen and helium.

46. The method claim 45, further comprising configuring the gas mixture to comprise at least one additional inert gas.

47. The method of claim 41, further comprising combining a first gas and a second gas upstream of the cell to provide the gas mixture.

48. The method of claim 41, further comprising altering a flow rate of the gas mixture provided to the cell when the cell is switched from the collision mode to the reaction mode.

49. The method of claim 41, further comprising configuring the cell with a single gas inlet configured to receive the gas mixture.

50. The method of claim 41, further comprising configuring a first gas to comprise up to about 15% by volume of the gas mixture.

51. A method of selecting ions using a cell comprising a quadrupolar rod set configured to operate in each of a collision mode and a reaction mode to select ions from an ion stream comprising a plurality of ions, the method comprising providing the binary gas mixture to the cell in the collision mode to select ions comprising an energy greater than a selected barrier energy and providing the binary gas mixture to the cell in the reaction mode to select ions using mass filtering.