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1. (WO2019030268) AGONISTES DU RÉCEPTEUR DE GLP-1/GLUCAGON DANS LE TRAITEMENT DE LA STÉATOSE HÉPATIQUE ET DE LA STÉATOHÉPATITE



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2018/071478 63774PWO
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
08 August 2018 09 August 2017
Applicant
SANOFI
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61K 38/22 (2006.01)i; A61K 38/26 (2006.01)i; A61P 1/16 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61K; A61P
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, BIOSIS, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
M. PILAR VALDECANTOS ET AL, "A novel glucagon-like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice", HEPATOLOGY,Vol. 65, No. 3, 01 March 2017 (2017-03-01), page 950-968,
XP055441389
1-8,11,13
A
the whole document
9,10,12
(2)
X
US 2014100156 A1 (HAACK TORSTEN [DE] ET AL) 10 April 2014 (2014-04-10)
1-8,11,13
A
claims 1,24,26
9,10,12
(3)
X
WO 2014096145 A1 (SANOFI SA [FR]) 26 June 2014 (2014-06-26)
1-8,11,13
A
claims 1,29
9,10,12
(4)
X
WO 2016198624 A1 (SANOFI SA [FR]) 15 December 2016 (2016-12-15)
1-8,11,13
A
claims 1,18
9,10,12
(5)
X
US 2017114115 A1 (ALSINA-FERNANDEZ JORGE [US] ET AL) 27 April 2017 (2017-04-27)
1-8,11,13
A
claims 1,3
9,10,12
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
US 2014100156 A1
10 April 2014
AR 092925 A1
AU 2013328802 A1
BR 112015007685 A2
CA 2887272 A1
CL 2015000811 A1
CL 2016002137 A1
CN 104837864 A
CR 20150200 A
DK 2906595 T3
DO P2015000073 A
EA 201590715 A1
EP 2906595 A1
ES 2647418 T3
GT 201500081 A
HK 1209766 A1
HR P20171726 T1
HU E037150 T2
JP 6373270 B2
JP 2015532297 A
KR 20150064093 A
LT 2906595 T
NZ 706898 A
PE 09002015 A1
PH 12015500688 A1
PT 2906595 T
SG 11201501770W A
SI 2906595 T1
TN 2015000101 A1
TW 201427992 A
UA 116217 C2
US 2014100156 A1
US 2016220643 A1
US 2018185450 A1
UY 35072 A
WO 2014056872 A1
ZA 201501694 B
06 May 2015
07 May 2015
08 August 2017
17 April 2014
11 September 2015
22 December 2017
12 August 2015
11 June 2015
27 November 2017
31 May 2015
30 November 2015
19 August 2015
21 December 2017
15 December 2017
08 April 2016
29 December 2017
28 August 2018
15 August 2018
09 November 2015
10 June 2015
27 November 2017
23 February 2018
16 June 2015
25 May 2015
16 November 2017
29 April 2015
29 December 2017
29 June 2016
16 July 2014
26 February 2018
10 April 2014
04 August 2016
05 July 2018
30 May 2014
17 April 2014
27 January 2016
WO 2014096145 A1
26 June 2014
AR 094178 A1
AR 094180 A1
AR 094181 A1
AR 099912 A1
AR 105816 A2
AU 2013360721 A1
AU 2013366690 A1
AU 2013366691 A1
AU 2013366692 A1
BR 112015013809 A2
BR 112015014510 A2
BR 112015014800 A2
CA 2894765 A1
CA 2895156 A1
CA 2895755 A1
CA 2895875 A1
CL 2015001751 A1
CL 2016002182 A1
CN 104870009 A
CN 104902918 A
CN 104902919 A
CN 104902920 A
CR 20150358 A
DK 2934567 T3
DK 2934568 T3
DO P2015000156 A
EA 201591174 A1
EP 2934566 A1
EP 2934567 A1
EP 2934568 A1
EP 2934569 A1
EP 3400957 A1
ES 2653765 T3
HK 1211231 A1
HK 1211232 A1
HK 1211233 A1
HK 1213483 A1
HR P20180092 T1
HR P20181300 T1
HU E035803 T2
JP 6391589 B2
JP 6408998 B2
JP 2016503770 A
JP 2016503771 A
JP 2016503772 A
JP 2016506401 A
KR 20150096398 A
KR 20150096433 A
KR 20150096684 A
KR 20150099548 A
LT 2934567 T
LT 2934568 T
MA 38276 A1
PE 12392015 A1
PH 12015501291 A1
PL 2934568 T3
PT 2934568 T
RU 2015129696 A
RU 2015129788 A
RU 2015129815 A
SG 10201705097P A
SG 11201503524P A
SG 11201503526U A
SG 11201503576X A
SG 11201504215P A
SI 2934567 T1
SI 2934568 T1
TN 2015000283 A1
TW 201429985 A
TW 201441251 A
TW 201441252 A
TW 201443080 A
UA 116553 C2
US 2014206608 A1
US 2014206609 A1
US 2014213513 A1
US 2014221281 A1
US 2017216406 A1
UY 35231 A
UY 35232 A
UY 35233 A
UY 35234 A
WO 2014096145 A1
WO 2014096148 A1
WO 2014096149 A1
WO 2014096150 A1
ZA 201503914 B
15 July 2015
15 July 2015
15 July 2015
31 August 2016
15 November 2017
09 July 2015
09 July 2015
09 July 2015
09 July 2015
14 November 2017
21 November 2017
10 October 2017
26 June 2014
26 June 2014
26 June 2014
26 June 2014
21 September 2015
12 January 2018
26 August 2015
09 September 2015
09 September 2015
09 September 2015
16 September 2015
13 August 2018
22 January 2018
31 August 2015
31 March 2016
28 October 2015
28 October 2015
28 October 2015
28 October 2015
14 November 2018
08 February 2018
20 May 2016
20 May 2016
20 May 2016
08 July 2016
23 February 2018
05 October 2018
28 May 2018
19 September 2018
17 October 2018
08 February 2016
08 February 2016
08 February 2016
03 March 2016
24 August 2015
24 August 2015
25 August 2015
31 August 2015
10 September 2018
12 February 2018
30 June 2017
08 September 2015
24 August 2015
30 March 2018
04 January 2018
27 January 2017
30 January 2017
27 January 2017
28 July 2017
29 June 2015
29 June 2015
29 June 2015
29 June 2015
30 October 2018
30 March 2018
03 October 2016
01 August 2014
01 November 2014
01 November 2014
16 November 2014
10 April 2018
24 July 2014
24 July 2014
31 July 2014
07 August 2014
03 August 2017
31 July 2014
31 July 2014
31 July 2014
31 July 2014
26 June 2014
26 June 2014
26 June 2014
26 June 2014
21 December 2016
WO 2016198624 A1
15 December 2016
NONE
US 2017114115 A1
27 April 2017
AR 106318 A1
AR 106325 A1
AU 2016344433 A1
AU 2016344434 A1
BR 112018007225 A2
CA 3000538 A1
CA 3003242 A1
CN 108135981 A
CN 108348583 A
EP 3368060 A1
EP 3368061 A1
JP 6321299 B2
JP 6354017 B2
JP 2018135346 A
JP 2018504376 A
JP 2018508464 A
KR 20180053747 A
TW 201726717 A
US 2017112904 A1
US 2017114115 A1
US 2018104312 A1
WO 2017074714 A1
WO 2017074715 A1
03 January 2018
03 January 2018
19 April 2018
07 June 2018
16 October 2018
04 May 2017
04 May 2017
08 June 2018
31 July 2018
05 September 2018
05 September 2018
09 May 2018
11 July 2018
30 August 2018
15 February 2018
29 March 2018
23 May 2018
01 August 2017
27 April 2017
27 April 2017
19 April 2018
04 May 2017
04 May 2017
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
16 October 2018
Date of mailing of the international search report:
07 November 2018
Authorized officer:
Rodrigo-Simón, Ana
Top    Part 1: 1 2 3 4 5 6         Part 2: A B C D E