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1. (WO2019005895) COMPLEXES DE CHITOSANE-MÉTAL FONGIQUES ET PROCÉDÉS POUR LES PRÉPARER ET LES UTILISER
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique


THAT WHICH IS CLAIMED A cationic solution comprising a chelated fungal cationic solution of claim wherein the fungal chltosan is about to by weight of The cationic solution of claim 1 or claim wherein the comprises chltosan chelated with 1 ppm to about The cationic solution of any of claims 1 to wherein the metal is or The cationic solution of any one of claims 1 to wherein the metal is The cationic solution of any one of claims 1 wherein the comprises an average particle size from about 10 μ to about 2000 pharmaceutical composition comprising the cationic solution of of claims 1 to and a pharmaceutically acceptable A method of making a cationic chelated fungal comprising dispersing chltosan in distilled water under agitation to produce a adding a citric acid solution to the fungal solution to produce a hydro lyzed fungal chitosan and adding an aqueous metal oxide solution to the hydrolyzed fungal chitosan thereby producing cationic chelated fungal solution The method of claim comprising preparing the citric acid solution at an elevated temperature of about to about to about The method of claim 8 or claim wherein the citric acid solution has a concentration of to about optionally about The method of any one of claims 8 to wherein the chitosan solution comprises chitosan at about 1 to about of the The method of any one of claims 8 to wherein the fungal chitosan has an average particle from about μΜ to about 2000 The method of one of claims 8 to 1 1 wherein the fungal chitosan an average particle size from μΜ to about method of any one of claims 8 wherein the fungal chitosan has an average particle from about 200 to about 750 The method of any one of claims wherein the aqueous oxide solution comprises metal oxide in The method of any one of claims to wherein the aqueous comprises a concentration of metal oxide of to about optionall to about ppm The method of any one of claims 8 to wherein the oxide is silver copper gold oxide or platinum The solution of an one of claims 8 to wherein the oxide is silver The method of one of claims 6 to wherein aqueous metal oxide solution prepared by agitating metal oxide in The method of claim wherein the agitation comprises a mild stirring to high method of claim wherein mild stirring to shear comprises about rpm to about 4000rpm for to about The cationic chelated fungal solution by the method of one of 8 to A pharmaceutical composition comprising the cationic chelated fungal solution of claim a pharmaceutically acceptable A method of stimulating the production of dermal fibroblasts and suppressing the production of typ I procollagen by hypertropie scar fibroblasts and keloids in a wound of subject in the contacting the wound of the subject with effective of the pharmaceutical composition of claim 7 or claim thereby stimulating the production of dermal and suppressing the production of type I and ill procollagen in the wound of the A method of reducing swelling in a subject in need the method contacting the swelling the with a therapeutically effective amount of the pharmaceutical composition of claim 7 or claim thereby reducing swelling in the A method of enhancing of wound in a subject in the contacting a wound in the subject with therapeutically effective of pharmaceutical composition of 7 or claim thereby enhancing healing of the wound in the A method of keeping a wound substantially free of bacteria or fungi a subject in need thereof or eliminating reducing the presence bacteria or fungi in a wound of a subject in need the method contacting the wound of the subject with a therapeuticall effecti ve amount of the pharmaceutical composition of claim 7 or claim thereby keeping the wound substantially of the subject free of bacteria o fungi or eliminating the presence bacteria or fungi in a wound of a A method of increasing the rate of recovery of damaged neural tissue in a subject in need the method contacting the damaged neural tissue in the subject with a therapeutically effective amount of the pharmaceutical composition of claim 7 or thereby increasing the rate of recovery of damaged neural tissue in a The method of claim wherein the damaged neural is in a wound in the The method of any one of claims 24 to 27 o wherein the wound is a a a a a a a an a a graft a skin or any combination The method of claim wherein the ulcer is a pressure a venous leg an arterial a diabetic foot or any combination The method of any one of claims 24 to 27 or 29 to wherein the wound is in soft The of any one of claims 24 to wherein the therapeutically effective amount of the pharaiaceutical composition is about to about metal oxide about ppm to The method of any one of claims 24 to wherein the subject is a a an an or a The method of one of claims 24 to wherein the subject is a insufficientOCRQuality