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1. (WO2019002536) NOUVEAUX BIOMARQUEURS À BASE D'ARNMI ET LEUR UTILISATION
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

CLAIMS

A nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 760, a fragment thereof, and a nucleotide sequence having at least 95% sequence identity thereto.

A nucleic molecule that is a complement to the nucleic acid molecule of claim 1.

A primer for reverse transcribing the nucleic acid molecule of claim 1.

A cDNA-transcript of the nucleic acid molecule of claim 1.

A set of primer pairs for amplifying the cDNA-transcript of claim 4.

A polynucleotide for detecting the nucleic acid molecule of claim 1.

The polynucleotide of claim 6, wherein the polynucleotide comprises a nucleotide sequence selected from the group consisting of SEQ ID NO: 761 to SEQ ID NO: 1520 and SEQ ID NO: 1521 to SEQ ID NO: 2280.

A nucleic acid molecule of claim 1, a nucleic acid molecule of claim 2, a primer of claim 3, a cDNA-transcript of claim 4, a set of primer pairs of claim 5, and/or a polynucleotide of claims 6 or 7 for use in diagnosing and/or prognosing a disease.

A nucleic acid molecule of claim 1, a nucleic acid molecule of claim 2, and/or a polynucleotide of claims 6 or 7 for use as a medicament.

A method for diagnosing and/or prognosing a disease in a patient comprising the steps of:

(i) determining the level of at least one nucleic acid molecule in a biological sample isolated from the patient, and

(ii) comparing the level to a reference level, wherein the comparison of said level to said reference level allows for the diagnosis and/or prognosis of the disease, wherein the at least one nucleic acid molecule comprises a nucleotide sequence selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 760, a fragment thereof, and a nucleotide sequence having at least 95% sequence identity thereto.

11. Means for determining the level of at least one nucleic acid molecule comprising:

(a) at least one polynucleotide of claims 6 or 7,

(b) at least one primer of claim 3, and/or

(c) at least one set of primer pairs of claim 5,

wherein the at least one nucleic acid molecule comprises a nucleotide sequence selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 760, a fragment thereof, and a nucleotide sequence having at least 95% sequence identity thereto.

12. Means for determining the level of at least one nucleic acid molecule comprising:

a microarray, a RT-PCT system, a PCR-system, a flow cytometer, a Luminex system and/or a next generation sequencing system.

wherein the at least one nucleic acid molecule comprises a nucleotide sequence selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 760, a fragment thereof, and a nucleotide sequence having at least 95% sequence identity thereto.

13. A kit for diagnosing and/or prognosing a disease comprising:

(a) means for determining the level of at least one nucleic acid molecule of any one of claims 11 or 12, and

(b) at least one reference level,

wherein the at least one nucleic acid molecule comprises a nucleotide sequence selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 760, a fragment thereof, and a nucleotide sequence having at least 95% sequence identity thereto.

14. A matrix comprising at least one polynucleotide which comprises a nucleotide sequence selected from the group consisting of SEQ ID NO: 761 to SEQ ID NO: 1520 and SEQ ID NO: 1521 to SEQ ID NO: 2280.