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1. (WO2018226245) DISPOSITIFS ET MÉTHODES POUR UNE PERFORATION AMÉLIORÉE DE LA PEAU POUR UNE SURVEILLANCE CONTINUE DU GLUCOSE
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique


CLAIMS We A method of in vo monitoring of an fluid analyte concentration creating plurality of micropores through a stratum layer of an area of the vidua s where the piuraiity of micropores forms a plurality of fluid paths having a distal end in fluid communication with interstitial fluid of the individual a proximal end in fluid communication with a sensing zone located outside of where the fluid paths comprise art interior space extending between the distal and proximal delivering a sensing fluid filling the the interior of the fluid allowing at least one analyte to diffuse from the interstitial through the paths and into the sensing and sensing a concentration of the at least one analyte in a sensing fluid within the sensing zone using a sensor located at least partially in the sensing wherein the sensing fluid formulation comprises a chelating agent and or biochemical inhibitors adapted to keep the created by the tissue piercing open for extended period to an analy te through the fluid paths and to mitigate a decrease over of the analyte flux through the fluid A method of in vivo monitoring of an interstitial fluid analyte concentration creating a piuraiity plurality of micropores through a stratum layer of an area of the the plurality of micropores define a plurality of fluid paths in communication with an interstitial of the a proximal end of the fluid paths being in fluid communication with a sensing located ou tside of the and where the sensing zone comprises a flexible sensor laminated to a buffered gel allowing at least one analyte to passivel diffuse from the interstitial fluid through the fluid paths and into the sensing zone the sensing gel formulation comprises a chelating agent and or biochemical adapted to keep the created by the tissue piercing open for extended period to maintain an uninterrupted analyte flux through the fluid paths to mitigate a decrease time of the anaiyte flux through fluid The method of claim I wherein the chelating agent comprises a sufficient concentration of agent to keep the skin micropores to maintain a constant anaiyte flux thro ugh the fluid paths for one and or several The method of claim 2 wherein the chelating the formulation comprises a sufficient agent to keep the skin micropores open to maintain a constant anai te through the fluid paths for one and or several The method of claim wherein the agent comprises eitrate ions and concentration of citrate ion ranges from mM to 250 The method of claim I or 2 wherein the fluid comprises a phosphate saline The method of claim 1 or 2 wherein the is The method of claim 1 or 2 wherein the anaiyte is other than glucose for example electrolytes or The method of claim or 2 further comprising inserting tissue piercing elements through the stratum layer using simple insertion An monitor a plurality of fluid each fluid pat comprising a opening to be disposed one side of a stratum layer of a a proximal opening adapted to be disposed on another side of the stratum coraeum layer and an interior space extending between the distal and a sensing zone in fluid communication with the proximal openings of the fluid and sensing fluid extending from the sensing zone into substantially the interior space of the fluid wherein the sensing fluid comprises one or more chelating agent adapted to keep the micropores or open to maintain constant anaiyte through the fluid paths and an anaiyte sensor adapted to detect a concentration of anaiyte in the sensing fluid within the sensing An monior a plurality of fluid paths via micropores through a stratum coraeum layer of an area of the said fluid paths are in communication wit interstitial fluid of a proximal end in fluid communication with a zone located outside of the and where the comprises a flexible sensor to a buffered gel allowing at least one anaiyte to passively diffuse from the interstitial fluid through the fluid paths and into the sensing zone where hi the sensing gel formulation comprises a chelating adapted to keep the created by the tissue piercing open for extended period to maintain a constant flux through the fluid paths to mitigate a decrease over time of the anaiyte flux through the fluid paths and an anaiyte sensor adapted to detect a concentration of in sensing fluid within the sensing The anaiyte monitor of claim wherein agent comprises a concentration of citrate in a range from to 250 ail The anaiyte monitor of claim sensing fluid comprises a phosphate buffered saline The anaiyte monitor of claim wherein the anaiyte comprises The anaiyte monitor of claim wherein the anaiyte is oilier than glucose for example electrolytes or The anaiyte monitor of claim wiierein the fluid paths each comprise a tissue piercing The anaiyte monitor of claim wherein the fluid paths do not comprise a tissue piercing The anaiyte monitor of claim 1 wherein the flexible electrochemical gel pad can be adapted and integrated into a simple easy to wearable wellness monitor for making healthy lifestyle decisions The anaiyte monitor of claim 1 wherein flexible electrochemical gel pad can be adapted t be integrated into a wearable wellness monitor containing other sensing devices to measure for example skin heart rate and motion The method of claim 1 and digital graphical feedback provided to the is the mm total of The analyte monitor of claim 1 and wherein the analyte monitor provides information regarding a general physiological condition of The wearable wellness monitor of claim 1 and 10 wherein the analyte monitor is not used for the diagnos is of diabetes or an other medical The wearable wellness of claim 1 and wherein the wellness is suitable for use by all individuals regardless of their health insufficientOCRQuality