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1. (WO2018224060) COMPOSITION ANTIMICROBIENNE COMPRENANT UN POLYSACCHARIDE, UN AGENT STABILISANT ET UN TRIIODURE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
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CLAIMS

1. An antimicrobial composition, characterized in that it comprises:

one or more polysaccharides and/or one or more chemically modified derivatives thereof,

a stabilizer of the general formula X,


wherein R is - an alkyl, aromatic, heteroaromatic, linear or branched chain Ci - C30, optionally containing N or O atoms,

R1 is - an alkyl, aromatic, heteroaromatic, linear or branched chain d - C30, optionally containing N or O atoms, or -H, wherein R1 in the stabilizer are independently the same or different,

and Y is a chloride, bromide or iodide anion,

and sodium or potassium triiodide.

2. The composition according to claim 1, characterized in that the polysaccharide or the chemically modified derivative thereof have the molecular weight in the range from 5x103 to lxl 06 g.mol"1 and are selected from the group comprising hyaluronic acid, sodium alginate, oxycellulose, carboxymethyl cellulose, hydroxyethyl cellulose or modified hyaluronic acid, where some -OH groups are substituted by -O-CO-R2 group and/or some -CO-OH groups are substituted by -CO-OR2 group, where R2 is a linear or aromatic chain with carbon atoms content d - Ci5, or mixture thereof.

3. The composition according to claim 1, characterized in that the stabilizer is selected from the group comprising thiamine, oxythiamine hydrochloride, 5-(2-hydroxyethyl)- 3,4-dimethyl thiazolium iodide and 3-benzyl-5-(2-hydroxyethyl)-4-methyl thiazolium bromide.

4. The composition according to any one of claims 1 to 3, characterized in that it is in a solid form selected from the group comprising lyophilizate, self-supporting film, non- woven fabric, endless fiber, woven fabric, knitted fabric, plaited fabric or a nanofiber layer.

5. A method of preparation of the composition defined in any one of claims 1 to 4, characterized in that the stabilizer of the general formula X


wherein R is - an alkyl, aromatic, heteroaromatic, linear or branched chain C1 - C30, optionally containing N or O atoms

R1 is - an alkyl, aromatic, heteroaromatic, linear or branched chain d - C30, optionally containing N or O atoms, or -H, wherein R1 in the stabilizer are independently the same or different,

and Y is a chloride, bromide or iodide anion,

and sodium or potassium triiodide are added to the system comprising a polysaccharide and/or a chemically modified derivative thereof and/or a mixture of polysaccharides and/or derivatives thereof, where the final form of the composition is produced.

6. The method of preparation of the composition according to claim 5, characterized in that the sodium or potassium triiodide at a concentration of 0.2 to 10% by weight, with respect to the total weight of all polysaccharides and derivatives thereof, and the stabilizer of the general formula X, wherein the molar ratio stabilizer/triiodide is in the range from 1/1 to 5/1, preferably 1.1/1, are added to 0.2 to 6% by weight solution of a polysaccharide and/or a chemically modified derivative thereof and/or a mixture of polysaccharides and/or derivatives thereof in a water/acetic acid solvent mixture in a volume ratio of 20/1 to 200/1, preferably 100/1, and then from the resulting mixture the respective final form of the composition is prepared.

7. The method of preparation of the composition defined in any one of claims 1 to 4, characterized in that the stabilizer of the general formula X


wherein R is - an alkyl, aromatic, heteroaromatic, linear or branched chain d - C30, optionally containing N or O atoms,

R1 is - an alkyl, aromatic, heteroaromatic, linear or branched chain Ci - C30, optionally containing N or O atoms, or -H, wherein R1 in the stabilizer are independently the same or different,

and Y is a chloride, bromide or iodide anion,

and the sodium or potassium triiodide are applied in the form of a solution in a solvent mixture ethanol/water to the final form of the medical device based on a polysaccharide or a chemically modified derivative thereof and/or a mixture of polysaccharides and/or derivatives thereof.

The method of preparation according to claim 7, characterized in that the application time is from 10 minutes to 72 hours and the temperature is in the range from 5 to 40 °C.

The method of preparation of the composition according to claim 7, characterized in that the application is performed by spraying the solution or by immersing into to the solution for 5 to 15 hours.

10. The method of preparation of the composition according to any one of claims 7 to 9, characterized in that the triiodide is in the solution at a concentration of 0.2 to 10% by weight, the molar ratio of the stabilizer/triiodide is in the range from 1/1 to 5/1, preferably 1.1/1, and the volume ratio of ethanol/water is in the range from 3/1 to 9/1.

11. The method of preparation of the composition according to any one of claims 5 to 10, characterized in that the final form of the composition includes lyophilizate, self- supporting film, nanofibre layer, non-woven fabric, fiber, knitted fabric, woven fabric and plaited fabric.

12. A medical device characterized in that it contains the antimicrobial composition as defined in any one of claims 1 to 4 and that it is in the form of a wound dressing or an implantable medical device.

13. Use of the composition as defined in claims 1 to 4 for the preparation of wound dressings.

14. Use of the composition as defined in claims 1 to 4 for the preparation of implantable medical devices.