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1. (WO2018122464) IMPRESSION TRIDIMENSIONNELLE AVEC UN BIOMATÉRIAU
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

CLAIMS:

1. A material for use in three-dimensional printing, characterized in that the material is 100 % bio-based and comprises 10 to 20 weight-% of an alginate and 1 to 30 weight-% of nanocellulose of the dry matter.

2. The material for use according to claim 1, characterized in comprising 5 to 95 weight-% of sugar alcohol, in particular glycerol or its derivative.

3. The material for use according to claim 1 or 2, characterized in comprising 40 to 70 weight-%) of glycerol, polyglycerol or triacetin.

4. The material for use according to any preceding claims, characterized in comprising a filler selected from talc, hydroxyapatite and tri-calcium phosphate.

5. The material for use according to claim 1, characterized in comprising 10 to 49 weight-% of polyvinyl alcohol instead of alginate.

6. The material for use according to any of the preceding claims, characterized in having antimicrobial properties.

7. A method for producing a three-dimensional object by forming successive layers of a material according to any of claims 1 to 6 under computer control.

8. The method according to claim 7, characterized by comprising the steps of:

(a) optionally mixing an alginate with a sugar alcohol to form a fluid mixture,

(b) mixing the formed fluid mixture or polyvinyl alcohol with nanocellulose to form a hydrogel,

(c) optionally carrying out ionic cross-linking of the hydrogel with a cross-linking agent,

(d) bio-printing a three-dimensional object, and

(e) curing the bio-printed three-dimensional object in room temperature, in an oven at temperatures between 100 °C and 150 °C, or by freeze-drying.

9. The method according to claim 7 or 8, characterized in that step (c) is replaced by filler loading, after which the material comprises up to 90 weight-% dry matter of a filler, wherein the filler is selected from talc, hydroxyapatite and tri-calcium phosphate.

10. The method according to any of claims 7 to 9, characterized in that the alginate is mixed with glycerol to form a fluid mixture in step (a).

11. A three dimensionally printed object, characterized in that the material is 100 % bio-based and comprises 10 to 20 weight-% of an alginate and 1 to 30 weight-%) of nanocellulose of the dry matter.

12. The three dimensionally printed object according to claim 11, characterized in comprising 5 to 95 weight-%o of sugar alcohol, in particular glycerol or its derivative.

13. A three dimensionally printed object, characterized in that the material is bio-based and comprises 10 to 49 weight-%o of polyvinyl alcohol and 1 to 30 weight-%o of nanocellulose of the dry matter.

14. The three dimensionally printed object according to any of claims 11 to 13, characterized by having antimicrobial properties, and being produced by the method of any of claims 7 to 10.

15. Use of the method according to any of claims 7 to 10 for producing three dimensional objects according to any of claims 11 to 14 for biomedical applications, such as objects for wound healing, wound dressing, tissue engineering and orthopaedic applications.