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1. (WO2018111620) MÉTHODE D'ADMINISTRATION D'UN MÉDICAMENT CONVENANT AU TRAITEMENT D'UNE MIGRAINE OU D'UNE ALGIE VASCULAIRE DE LA FACE

Pub. No.:    WO/2018/111620    International Application No.:    PCT/US2017/064657
Publication Date: Fri Jun 22 01:59:59 CEST 2018 International Filing Date: Wed Dec 06 00:59:59 CET 2017
IPC: A61M 37/00
A61M 5/168
A61M 5/158
A61M 15/00
A61M 11/02
Applicants: SORRENTO THERAPEUTICS, INC.
Inventors: ROSS, Russell F.
BAKER, Andrew T.
HAGAN, Luke
Title: MÉTHODE D'ADMINISTRATION D'UN MÉDICAMENT CONVENANT AU TRAITEMENT D'UNE MIGRAINE OU D'UNE ALGIE VASCULAIRE DE LA FACE
Abstract:
A method for administering a medicament suitable for treating a migraine or cluster headache to a patient in need thereof includes placing a mounting surface of a fluid delivery apparatus with the medicament in contact with at least a portion of the skin of said patient. A flow rate of the medicament from the fluid delivery apparatus is adjusted such that the medicament is delivered to the patient for at least a predetermined time period. The fluid delivery apparatus includes a controller assembly having a body component defining an axis and a plunger component slidably coupled to the body component. The plunger is positionable between a first position in which the plunger is nearest to the body component and a second position in which the plunger component is furthest from the body component. A bias assembly is positioned between the body component and the plunger component. The bias assembly is configured to apply a two stage force profile to the plunger component. Also disclosed is method for administering a medicament to a patient in need thereof such that the Cmax, Tmax and AUC are within predetermined, therapeutically effective values. Such methods are effective in treating migraine and cluster headaches with sumatriptan or other medicament.