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1. (WO2018087532) COMPOSITIONS COMPRENANT DU FLUORURE ET DU CALCIUM ET LEUR PROCÉDÉ DE PRÉPARATION
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Claims

1. A method of preparing a liquid composition comprising stabilised amorphous calcium phosphate and fluoride, the method comprising:

a) providing a source of calcium ions, a source of phosphate ions, a calcium

phosphate-stabilising agent, and monofluorophosphate;

b) mixing said source of calcium ions and said source of phosphate ions together with the calcium phosphate-stabilising agent in a liquid medium in order to form a stabilised amorphous calcium phosphate complex;

c) mixing the monofluorophosphate with the source of calcium ions, source of

phosphate ions, calcium phosphate-stabilising agent and/or stabilised amorphous calcium phosphate complex in the liquid medium;

thereby producing a liquid composition comprising stabilised amorphous calcium phosphate and fluoride.

2. A method according to claim 1 wherein the monofluorophosphate is mixed with the source of calcium ions, source of phosphate ions, and calcium phosphate-stabilising agent before formation of the stabilised calcium phosphate complex has completed or has reached an equilibrium point.

3. A method according to claim 2 wherein the monofluorophosphate, source of calcium ions, source of phosphate ions, and calcium phosphate-stabilising agent are all mixed together in a single reaction.

4. The method according to any preceding claim wherein the monofluorophosphate, source of calcium ions, source of phosphate ions, and calcium phosphate-stabilising agent are added to a single reaction vessel with the liquid medium and mixed together and allowed to react together.

5. The method according to any preceding claim comprising storing the liquid

composition under suitable conditions for monofluorophosphate to decompose to release fluoride into the liquid medium.

6. The method according to any preceding claim wherein the source of calcium ions is a soluble calcium salt, suitably a calcium salt having a solubility of 5g of salt per 100ml of liquid medium or higher, preferably 10g of salt per 100ml of liquid medium or higher, yet more preferably 50g of salt per 100ml of liquid medium or higher.

7. The method according to any preceding claim wherein the source of calcium ions is calcium chloride.

8. The method according to any preceding claim wherein the source of phosphate ions is a soluble phosphate salt, suitably a phosphate salt having a solubility of 5g of salt per 100ml of liquid medium or higher, preferably 10g of salt per 100ml of liquid medium or higher, yet more preferably 50g of salt per 100ml of liquid medium or higher.

9. The method according to any preceding claim wherein the source of phosphate ions is sodium phosphate, suitably disodium hydrogen phosphate and/or trisodium phosphate.

10. The method according to any preceding claim wherein the calcium phosphate- stabilising agent is a phosphoprotein or phosphopeptide.

1 1 . The method according to any preceding claim wherein the calcium phosphate- stabilising agent comprises osteopontin or phosphopeptides derived therefrom, and/or casein or phosphopeptides derived therefrom.

12. The method according to claim 10 wherein the calcium phosphate-stabilising agent comprises osteopontin phosphopeptides or casein phosphopeptides.

13. The method according to any preceding claim wherein the liquid medium is an

aqueous medium.

14. The method according to any preceding claim wherein the liquid medium is water.

15. The method according to any preceding claim wherein the final pH of the liquid

composition is greater than 7.

16. The method any preceding claim comprising adjusting the pH of the composition using an acid or base.

17. The method of any preceding claim comprising adding a pH buffering agent.

18. The method of any preceding claim comprising adding one or more of the following: alcohol, humectant, surfactant, preservative, flavouring agent, cooling agent, sweetening agent, colouring agent, and anti-caries agent.

19. The method according to any preceding claim wherein the liquid composition is an oral spray or mouthwash.

20. A liquid composition comprising stabilised amorphous calcium phosphate and fluoride obtained by the method of any one of claims 1 to 19.

21. An oral care product, suitably an oral spray or mouthwash, comprising a liquid

composition comprising stabilised amorphous calcium phosphate and fluoride obtained by the method of any one of claims 1 to 19.

22. A method of treating or preventing dental erosion and/or dental caries by administering a composition or product according to claim 20 or 21 to the oral cavity of a subject, e.g. a human.

23. A composition or product according to claim 20 or 21 for use in the treatment or

prevention of dental erosion by administering a composition according to the present invention to the oral cavity of a subject, e.g. a human.

24. A liquid composition comprising amorphous calcium phosphate stabilised by a calcium phosphate-stabilising agent and monofluorophosphate.

25. An oral care product comprising a liquid composition according to claim 24.