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1. (WO2017143357) MODULE À BASSE TEMPÉRATURE POUR UN SYSTÈME DE DÉPÔT D'IMPRIMANTE BIOLOGIQUE 3D ET PLATEFORME DE CONSTRUCTION
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

CLAIMS

1. A method of changing and maintain the temperature within a 3D biological printer's fabrication system of at least one degrees Celsius (1 °C) below ambient temperature.

2. A method of changing and maintain the temperature within a 3D biological printer's build platform of at least one degrees Celsius (1 °C) below ambient temperature.

3. The method of claim 1, wherein the low temperature module for the fabrication

system maintains a constantly cold environment of at least one degrees Celsius (1 °C) below ambient temperature for the fabrication head until the fabrication process is complete.

4. The method of claim 2, where in the low temperature module for the build platform maintains a constantly cold environment of at least one degrees Celsius (1 °C) below ambient temperature from the fabrication head until the fabrication process is complete.

5. The method of claim 1, wherein the extruded bioactive filament maintains cell

viability of at least 70%.

6. The method of claim 1, wherein the extruded bioactive filament includes one or more selected from the group consisting of: a polymer, a solution, a cell-lade solution, a chemically reactive solution, an aqueous solution, sodium alginate solutions, a sacrificial support material, a cell, alginate, a cross-linker, a cross-linking solution, a calcium chloride solution, and a hydrogel.

7. The method of claim 1, wherein the extruded bioactive filament is produced by

uniform mass flow rate.

8. The method of claim 1, wherein the extruded bioactive filament is produced by a gradient mass flow rate.

9. The method of claim 1, wherein the extruded bioactive filament is produced by

backwards mass flow rate.

10. The method of claim 1, wherein the extruded bioactive filament in-part comprised of one or more living cells.

11. The method of claim 1, wherein the extruded bioactive filament has no living

biologies.

12. The method of claim 1, wherein the extruded bioactive filament is symmetrical along a longitudinal axis

13. The method of claim 1, wherein the extruded bioactive filament is asymmetrical along a longitudinal axis.

14. The method of claim 1, wherein the extruded bioactive filament has one-dimensional pattern.

15. The method of claim 1, wherein the extruded bioactive filament has two-dimensional pattern.

16. The method of claim 1, wherein the extruded bioactive filament has three- dimensional pattern.

17. The method of claim 1, wherein the extruded bioactive filament has a largest cross- sectional dimension less than about 1 mm.

18. The method of using one of more fabrication head using the method in claim 1 : producing methods of claim 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, and 16.

19. The method of claim 1, wherein the bioactive filament is used to produce:

microfluidic tissue constructs, tissue scaffolds, tissue-on-chip, organ-on-a-chip.

20. The method of claim 2, wherein the extruded bioactive filament maintains cell

viability of at least 70%.

21. The method of claim 2, wherein the extruded bioactive filament includes one or more selected from the group consisting of: a polymer, a solution, a cell-lade solution, a chemically reactive solution, an aqueous solution, sodium alginate solutions, a sacrificial support material, a cell, alginate, a cross-linker, a cross-linking solution, a calcium chloride solution, and a hydrogel.

22. The method of claim 2, wherein the extruded bioactive filament is produced by

uniform mass flow rate.

23. The method of claim 2, wherein the extruded bioactive filament is produced by a gradient mass flow rate.

24. The method of claim 2, wherein the extruded bioactive filament is produced by

backwards mass flow rate.

25. The method of claim 2, wherein the extruded bioactive filament in-part comprised of one or more living cells.

26. The method of claim 2, wherein the extruded bioactive filament has no living biologies.

27. The method of claim 2, wherein the extruded bioactive filament is symmetrical along a longitudinal axis

28. The method of claim 2, wherein the extruded bioactive filament is asymmetrical along a longitudinal axis.

29. The method of claim 2, wherein the extruded bioactive filament has one-dimensional pattern.

30. The method of claim 2, wherein the extruded bioactive filament has two-dimensional pattern.

31. The method of claim 2, wherein the extruded bioactive filament has three- dimensional pattern.

32. The method of claim 2, wherein the extruded bioactive filament has a largest cross- sectional dimension less than about 1 mm.

33. The method of using one of more fabrication head using the method in claim 2: producing methods of claim 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, and 16.

34. The method of claim 2, wherein the bioactive filament is used to produce:

microfluidic tissue constructs, tissue scaffolds, tissue-on-chip, organ-on-a-chip.

35. A method wherein the methods of claims 1 and 2 can be used dependently and

independently.