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1. (WO2017004598) DISPOSITIFS MÉDICAUX À MICRO-FILET À FILM MINCE ET PROCÉDÉS ASSOCIÉS
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

CLAIMS

What is claimed is:

1. A method comprising:

deep reactive ion etching a micropattern of trenches on a surface of a substrate, the trenches corresponding to pores in a thin-film micromesh to be formed;

depositing a lift-off layer on the etched substrate;

depositing a first Nitinol layer over the lift-off layer;

etching the lift-off layer to form the thin-film micromesh, wherein the thin-film mesh has a pore density of between 65 and 1075 pores per mm2 and a percent area coverage of between 16 and 66%; and

placing the thin-film micromesh in a solution including structural proteins to form a fibrinous layer on the thin-film micromesh.

2. The method of claim 1 , further comprising:

depositing a bonding layer on at least one area of the first Nitinol layer;

depositing a sacrificial layer on a remaining area of the first Nitinol layer;

depositing a second Nitinol layer on the bonding layer and the sacrificial layer; and annealing the first Nitinol layer and the second Nitinol layer with the bonding layer; wherein the etching further etches the sacrificial layer to form the thin-film micromesh having a three dimensional shape.

3. The method of claim 1, further comprising:

shaping the thin-film mesh to a three-dimensional thin-film micromesh.

4. The method of claim 1 , further comprising:

forming a plurality of thin-film micromeshes;

stacking the thin-film micromeshes to form a three-dimensional thin-film micromesh structure; and

placing the three-dimensional thin-film micromesh structure in the solution including the structural proteins to form the fibrinous layer on the three-dimensional thin-film micromesh structure.

5. The method of claim 1, further comprising:

seeding the thin-film micromesh with cells; and

incubating the thin-film micromesh to promote cell growth.

6. A thin-film micromesh device comprising:

a thin-film micromesh with a plurality of pores, the thin-film micromesh having a pore density of between 65 and 1075 pores per mm2 and a percent area coverage of between 16 and 66; and

a fibrinous layer formed on the thin-film micromesh.

7. The thin-film micromesh device of claim 1 , wherein the thin-film micromesh comprises thin-film Nitinol (TFN).

8. The thin-film micromesh device of claim 1, wherein the thin-film mesh is fabricated with a plurality of slits, wherein the thin-film mesh expands to open up the slits to corresponding pores.

9. The thin-film micromesh device of claim 1 , further comprising:

a seeded cell layer on the thin-film micromesh.

10. The thin-film micromesh device of claim 1, further comprising:

a backbone;

wherein the thin-film mesh is assembled on the backbone.

1 1. The thin-film micromesh device of claim 10, wherein the backbone comprises a metal or a bioabsorable material.

12. The thin-film micromesh device of claim 10, wherein the backbone is a stent backbone, and wherein the thin-film mesh has a pore density that varies along the longitudinal axis of the stent backbone.

13. The thin-film micromesh device of claim 1, further comprising a first stent backbone and a second stent backbone, wherein the thin-film mesh is assembled over the first and second stent backbones, and wherein the first stent backbone is configured to receive the second backbone through a medial opening of the first stent backbone.

14. The thin-film micromesh device of claim 1, wherein the thin-film mesh includes pore edges forming a fractal shape.

15. The thin-film micromesh device of claim 1 , further comprising a plurality of thin-film meshes.

16. The thin-film micromesh device of claim 15, wherein the thin-film meshes form a first a first cylindrical membrane and a second cylindrical membrane, and wherein the first cylindrical membrane is disposed within the second cylindrical membrane.

17. The thin-film micromesh device of claim 1, wherein the thin-film mesh are stacked to form a three-dimensional thin-film micromesh structure.

18. A method comprising:

placing, using a microcatheter, a first thin-film stent module at a bifurcated aneurysm site such that the first thin-film stent module extends from a blood vessel to one side of bifurcation, wherein the first thin-film stent module includes a first thin-film micromesh and a first stent backbone;

making an opening through the first thin-film micromesh with a penetrating wire at a medial portion of the first thin-film stent module, wherein the medial portion is at or near the bifurcated aneurysm; and

placing, using a microcatheter, a second thin-film stent module at the bifurcated aneurysm site such that the second thin-film stent module extends from the blood vessel through the opening to the other side of bifurcation, wherein the second thin-film stent includes a second thin-film micromesh and a second stent backbone.

19. The method of claim 16, wherein making the opening through the first thin-film micromesh comprises pushing a sharp tip or a barbed portion of the piercing wire through the first thin-film micromesh.

20. The method of claim 18, wherein the first thin-film micromesh only covers a distal portion of the first stent backbone for placement at the one side of bifurcation or the second thin-film micromesh only covers a distal portion of the second stent backbone for placement at the other side of bifurcation.