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1. (WO2017004149) PROTÉINES DE LIAISON MULTI-SPÉCIFIQUES



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2016/040007 09-0642-WO-1
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
29 June 2016 30 June 2015
Applicant
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No.     1    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C07K 16/24 (2006.01)i; C07K 16/28 (2006.01)i; C07K 16/30 (2006.01)i; C07K 16/46 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C07K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, BIOSIS, MEDLINE, EMBASE

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 2013096291 A2 (MEDIMMUNE LLC [US]) 27 June 2013 (2013-06-27)
1-10,24-38
Y
page 22, line 31 - page 23, line 2
11-23
page 24, line 33 - page 25, line 14
page 54, line 6 - page 57, line 5; tables 5,8
page 57, line 6 - page 58, line 1
page 58, line 11 - page 58, line 32; claims 21-28
page 62, line 25 - page 63, line 9
page 66, line 25 - page 76, line 29
page 86, line 18 - line 20
(2)
Y
WO 2011117330 A1 (ROCHE GLYCART AG [CH]; BRINKMANN ULRICH [DE]; CROASDALE REBECCA [DE];) 29 September 2011 (2011-09-29)
11-23
page 3, line 6 - page 4, line 3; figures 3a,3b
page 8, line 33 - page 9, line 18
page 11, line 5 - line 11
page 29, line 14 - line 21
(3)
Y
CA 2892623 A1 (AJOU UNIV IND ACAD COOP FOUND [KR]) 05 June 2014 (2014-06-05)
11-23
figure 23A; example 7
(4)
A
JOHN-PAUL SILVA ET AL, "The S228P Mutation Prevents in Vivo and in Vitro IgG4 Fab-arm Exchange as Demonstrated using a Combination of Novel Quantitative Immunoassays and Physiological Matrix Preparation", JOURNAL OF BIOLOGICAL CHEMISTRY,Vol. 290, No. 9, 27 February 2015 (2015-02-27), page 5462-5469,
XP055299482
5,6,9
abstract
(5)
A
HEZAREH M ET AL, "Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US,Vol. 75, No. 24, 01 December 2001 (2001-12-01), page 12161-12168,
XP002339184
5,6,8
abstract
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2013096291 A2
27 June 2013
AU 2012355415 A1
CA 2859667 A1
CN 104011221 A
EP 2794905 A2
HK 1203560 A1
JP 2015502409 A
US 2014348839 A1
WO 2013096291 A2
17 July 2014
27 June 2013
27 August 2014
29 October 2014
30 October 2015
22 January 2015
27 November 2014
27 June 2013
WO 2011117330 A1
29 September 2011
AR 080793 A1
CA 2789074 A1
CN 102946902 A
EP 2552481 A1
HK 1182625 A1
JP 5726287 B2
JP 2013523104 A
KR 20120130276 A
RU 2012143798 A
TW 201138821 A
US 2011293613 A1
WO 2011117330 A1
09 May 2012
29 September 2011
27 February 2013
06 February 2013
19 February 2016
27 May 2015
17 June 2013
29 November 2012
10 May 2014
16 November 2011
01 December 2011
29 September 2011
CA 2892623 A1
05 June 2014
AU 2013352812 A1
CA 2892623 A1
CN 104955953 A
EA 201591038 A1
EP 2927321 A1
JP 2016506377 A
KR 20140067944 A
US 2015307628 A1
WO 2014084607 A1
16 July 2015
05 June 2014
30 September 2015
30 November 2015
07 October 2015
03 March 2016
05 June 2014
29 October 2015
05 June 2014
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
08 September 2016
Date of mailing of the international search report:
04 October 2016
Authorized officer:
Loubradou, Gabriel
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