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1. (WO2017004035) VALVE CARDIAQUE PROTHÉTIQUE COMPOSÉE DE FIBRES COMPOSITES
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

CLAIMS

We claim:

1 . A prosthetic heart valve leaflet comprising a fiber-reinforced structure including a plurality of composite fibers, each composite fiber comprising a core fiber and a sheathing fiber disposed about the core fiber, characterized by the core fiber or the sheathing fiber having a curvilinear shape.

2. The prosthetic heart valve leaflet of claim 1 , wherein the sheathing fiber has the curvilinear shape, the sheathing fiber being spirally disposed about the core fiber.

3. The prosthetic heart valve leaflet of claim 1 or claim 2, wherein the sheathing fiber helically wraps around a longitudinal axis defined by the composite fiber.

4. The prosthetic heart valve leaflet of any one of claims 1 -3, wherein a ratio of core diameter to sheathing fiber diameter ranges from about 1 :1 to 1 :2.

5. The prosthetic heart valve leaflet of any one of claims 1 -4, wherein weight ratio of the core fibers to the sheathing fibers ranges from 0.2 to 5.0.

6. The prosthetic heart valve leaflet of any one of claims 1 -5, wherein the core fiber and the sheathing fiber are made of different polymeric materials.

7. The prosthetic heart valve leaflet of any one of claims 1 -6, wherein the core fiber comprises an elastomer and the sheathing fiber comprises a thermoplastic polymer.

8. The prosthetic heart valve leaflet of any one of claims 1 -7, wherein the core fiber comprises a tensile modulus that is greater than a tensile modulus of the sheathing fiber.

9. The prosthetic heart valve leaflet of any one of claims 1 -8, wherein the core fiber or the sheathing fiber comprises carbon fillers.

10. The prosthetic heart valve leaflet of any one of claims 1 -9, wherein the composite fiber includes a coating comprising polyethylene glycol.

1 1 . The prosthetic heart valve leaflet of any one of claims 1 -10, wherein the composite fiber comprises at least two sheathing fibers spirally disposed about the core fiber.

12. The prosthetic heart valve leaflet of any one of claims 1 -1 1 , wherein the at least two sheathing fibers are spirally disposed about one another and the core fiber.

13. The prosthetic heart vaive leaflet of claim 1 , wherein the core fiber is encapsulated within the sheathing fiber, the core fiber having an undulating shape within the sheathing fiber relative to a longitudinal axis defined by the composite fiber.

14. The prosthetic heart vaive leaflet of claim 13, wherein the core has the undulating shape within the sheathing fiber when the fiber is in a relaxed state, but a straight shape within the sheathing fiber when the composite fiber is stretched in a strained state.

15. The prosthetic heart valve leaflet of claim 13 or claim 14, wherein the composite fibers are electrospun composite fibers.

16. A prosthetic heart valve leaflet comprising a fiber-reinforced structure including a plurality of composite fibers, each composite fiber comprising a core fiber and a sheathing fiber disposed about the core fiber, wherein the core fiber or the sheathing fiber has a curvilinear shape.

17. The prosthetic heart valve leaflet of claim 16, wherein the sheathing fiber has the curvilinear shape, the sheathing fiber being spirally disposed about the core fiber.

18. The prosthetic heart valve leaflet of claim 16, wherein the sheathing fiber helically wraps around a longitudinal axis defined by the composite fiber.

19. The prosthetic heart vaive leaflet of claim 16, wherein a ratio of core diameter to sheathing fiber diameter ranges from about 1 :1 to 1 :2.

20. The prosthetic heart valve leaflet of claim 16, wherein weight ratio of the core fiber to the sheathing fiber ranges from 1 :5 to 5:1 .

21 . The prosthetic heart valve leaflet of claim 16, wherein the core fiber and the sheathing fiber are made of different polymeric materials.

22. The prosthetic heart vaive leaflet of claim 16, wherein the core fiber comprises an elastomer and the sheathing fiber comprises a thermoplastic polymer.

23. The prosthetic heart vaive leaflet of claim 16, wherein the core fiber comprises a tensile modulus that is greater than a tensile modulus of the sheathing fiber.

24. The prosthetic heart valve leaflet of claim 16, wherein the core fiber or the sheathing fiber comprises carbon fillers.

25. The prosthetic heart vaive leaflet of claim 16, wherein the composite fiber includes a coating comprising polyethylene glycol.

26. The prosthetic heart valve leaflet of claim 16, wherein the composite fiber comprises at least two sheathing fibers spirally disposed about the core fiber.

27. The prosthetic heart valve leaflet of claim 16, wherein the at least two sheathing fibers are spirally disposed about one another and the core fiber.

28. The prosthetic heart valve leaflet of claim 16, wherein the core fiber is encapsulated within the sheathing fiber, the core fiber having an undulating shape within the sheathing fiber relative to a longitudinal axis defined by the composite fiber.

29. The prosthetic heart valve leaflet of claim 28, wherein the core has the undulating shape within the sheathing fiber when the fiber is in a relaxed state, but a straight shape within the sheathing fiber when the composite fiber is stretched in a strained state.

30. The prosthetic heart valve leaflet of claim 28, wherein the composite fibers are electrospun composite fibers.

31 . The prosthetic heart valve leaflet of claim 28, wherein a ratio of a core fiber diameter to a sheathing fiber thickness ranges from 0.2 to 5.0.

32. The prosthetic heart valve leaflet of claim 28, wherein the core fiber comprises a thermoplastic polymer and the sheathing fiber comprises an elastomeric core,

33. A method of forming a prosthetic heart valve leaflet material, the method comprising forming composite fibers comprises forming a core fiber and spirally wrapping a sheathing fiber about the core fiber.

34. The method of claim 33, wherein forming a portion of the composite fiber comprises using an emulsion eiectrospinning process, a coaxial electro spinning process, or co-electrospinning multiple polymers simultaneously.

35. The method of claim 33, further comprising forming a fiber-reinforced structure by disposing a plurality of composite fibers within a polymer matrix.