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1. (WO2017004025) CONJUGUÉS D'ANTICORPS À CYSTÉINE MODIFIÉE



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2016/039796 121162-01320
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
28 June 2016 29 June 2015
Applicant
IMMUNOGEN, INC.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into English which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61P 35/00 (2006.01)i; C07D 487/04 (2006.01)i; C07D 519/00 (2006.01)i; C07K 16/28 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61K; C07D; C07K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, EMBASE, BIOSIS

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 9614339 A1 (WELLCOME FOUND [GB]; KULL FREDERICK CHARLES JR [US]; FLING MARY ELIZAB) 17 May 1996 (1996-05-17)
1-6,77,141-146
examples 1-7
page 7, paragraph 3 - page 10, paragraph 1
(2)
X
STIMMEL J B ET AL, "Site-specific conjugation on serine right-arrow cysteine variant monoclonal antibodies", 29 September 2000 (2000-09-29), Vol. 275, No. 39, page 30445-30450,
XP002714201
[retrieved on  2000-07-03]
1-6,77,141
abstract
page 30447, column 2, paragraph 5 - page 30448, column 1, paragraph 2
page 30450, column 1, paragraph 2
(3)
X
WO 2012128868 A1 (IMMUNOGEN INC [US]; LI WEI [US]; MILLER MICHAEL [US]; FISHKIN NATHAN [) 27 September 2012 (2012-09-27)
78-140
A
examples 1-32
1-77,141-146
(4)
X
WO 2010091150 A1 (IMMUNOGEN INC [US]; LI WEI [US]; FISHKIN NATHAN ELLIOTT [US]; ZHAO ROB) 12 August 2010 (2010-08-12)
78-140
examples 1-40
(5)
A
US 8557966 B2 (AB OLGA [US] ET AL) 15 October 2013 (2013-10-15)
1-77,141-146
cited in the application
examples 1-19
column 42, line 13 - column 47, line 55
column 49, line 9 - column 53, line 3
(6)
X,P
WO 2015196167 A1 (BIOALLIANCE C V [NL]; ABGENOMICS INTERNAT INC [US]) 23 December 2015 (2015-12-23)
1-6,77,141-146
examples 1-6
paragraphs [0027] - [0029]
(7)
X,P
WO 2015196089 A1 (BIOALLIANCE C V [NL]; ABGENOMICS INTERNAT INC [US]) 23 December 2015 (2015-12-23)
1-6,77,141-146
examples 1-5
paragraphs [0236] - [0238]
(8)
X,P
WO 2016036861 A1 (IMMUNOGEN INC [US]) 10 March 2016 (2016-03-10)
78-140
table 1; compounds D4-D7
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 9614339 A1
17 May 1996
AU 3811495 A
EP 0789713 A1
JP H10508482 A
WO 9614339 A1
ZA 9509336 B
31 May 1996
20 August 1997
25 August 1998
17 May 1996
05 May 1997
WO 2012128868 A1
27 September 2012
AU 2012217719 A1
AU 2012231640 A1
AU 2016200752 A1
CA 2824864 A1
CA 2825919 A1
CN 103687623 A
CN 103702686 A
DK 2675479 T3
EP 2675479 A1
EP 2675480 A1
EP 2675481 A1
EP 3053600 A1
ES 2567418 T3
HK 1186686 A1
HR P20160164 T1
JP 5826863 B2
JP 2014506892 A
JP 2014521591 A
JP 2016040298 A
KR 20140010067 A
KR 20140010076 A
NZ 613121 A
NZ 613162 A
RU 2013141829 A
RU 2013142179 A
SG 191955 A1
SG 191965 A1
SG 10201601046Q A
SI 2675479 T1
SM T201600099 B
TW 201309674 A
US 2012238731 A1
US 2012244171 A1
US 2013302359 A1
US 2014088089 A1
US 2015099874 A1
US 2016108129 A1
WO 2012112687 A1
WO 2012112708 A1
WO 2012128868 A1
18 April 2013
02 May 2013
25 February 2016
27 September 2012
23 August 2012
26 March 2014
02 April 2014
11 April 2016
25 December 2013
25 December 2013
25 December 2013
10 August 2016
22 April 2016
08 July 2016
11 March 2016
02 December 2015
20 March 2014
28 August 2014
24 March 2016
23 January 2014
23 January 2014
29 May 2015
30 October 2015
27 March 2015
27 March 2015
30 August 2013
30 August 2013
30 March 2016
29 April 2016
29 April 2016
01 March 2013
20 September 2012
27 September 2012
14 November 2013
27 March 2014
09 April 2015
21 April 2016
23 August 2012
23 August 2012
27 September 2012
WO 2010091150 A1
12 August 2010
AU 2010210646 A1
BR PI1008749 A2
CA 2750519 A1
CN 102365021 A
CN 105175434 A
CN 105198908 A
EP 2393362 A1
IL 214475 A
JP 5977522 B2
JP 2012516896 A
JP 2015017095 A
JP 2015187144 A
KR 20110120308 A
NZ 594177 A
NZ 620649 A
RU 2011136686 A
RU 2015103852 A
SG 173152 A1
SG 2014009138 A
US 2010203007 A1
US 2013266596 A1
US 2013302357 A1
US 2015030616 A1
US 2016222013 A1
WO 2010091150 A1
ZA 201105352 B
11 August 2011
25 August 2015
12 August 2010
29 February 2012
23 December 2015
30 December 2015
14 December 2011
29 October 2015
24 August 2016
26 July 2012
29 January 2015
29 October 2015
03 November 2011
28 February 2014
25 September 2015
20 March 2013
10 November 2015
29 August 2011
28 March 2014
12 August 2010
10 October 2013
14 November 2013
29 January 2015
04 August 2016
12 August 2010
25 September 2014
US 8557966 B2
15 October 2013
AR 080301 A1
AU 2011220728 A1
CA 2790412 A1
CN 103037900 A
CN 105777907 A
EP 2538976 A1
JP 5778700 B2
JP 2013524773 A
JP 2016000729 A
JP 2016153412 A
KR 20130012117 A
KR 20150031488 A
KR 20160083962 A
NZ 601617 A
NZ 621938 A
RU 2012135395 A
SG 183144 A1
SG 10201501342U A
TW 201138816 A
TW 201607555 A
US 2012009181 A1
US 2013295119 A1
US 2016060339 A1
US 2016075781 A1
US 2016083471 A1
US 2016096887 A1
US 2016096888 A1
WO 2011106528 A1
28 March 2012
30 August 2012
01 September 2011
10 April 2013
20 July 2016
02 January 2013
16 September 2015
20 June 2013
07 January 2016
25 August 2016
01 February 2013
24 March 2015
12 July 2016
28 March 2014
31 July 2015
27 March 2014
27 September 2012
29 April 2015
16 November 2011
01 March 2016
12 January 2012
07 November 2013
03 March 2016
17 March 2016
24 March 2016
07 April 2016
07 April 2016
01 September 2011
WO 2015196167 A1
23 December 2015
TW 201613642 A
US 2016015827 A1
WO 2015196167 A1
16 April 2016
21 January 2016
23 December 2015
WO 2015196089 A1
23 December 2015
TW 201613641 A
US 2016015831 A1
WO 2015196089 A1
16 April 2016
21 January 2016
23 December 2015
WO 2016036861 A1
10 March 2016
US 2016058884 A1
WO 2016036861 A1
03 March 2016
10 March 2016
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
20 September 2016
Date of mailing of the international search report:
27 September 2016
Authorized officer:
Monami, Amélie
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