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1. (WO2017001980) SYSTÈME DE PERFUSION ET MÉTHODE DE TRAITEMENT D'ACCIDENT VASCULAIRE CÉRÉBRAL PAR THROMBOLYSE ULTRASONORE
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

WHAT IS CLAIMED IS:

1. A sonothrombolysis infusion system

comprising :

a syringe pump;

a syringe having a barrel configured to hold a microbubble solution containing a plurality of magnetic beads, the syringe being mounted on the syringe pump; and

a magnetic stirrer mounted in proximity to the barrel of the syringe.

2. The sonothrombolysis infusion system of Claim 1, wherein the magnetic stirrer further comprises a plurality of moving magnets.

3. The sonothrombolysis infusion system of Claim 2, wherein the magnetic stirrer further comprises a rotating rod having an outer

circumference in proximity to the barrel of the syringe,

wherein the magnets are mounted on the rotating rod .

4. The sonothrombolysis infusion system of

Claim 3, wherein the rotating rod is substantially parallel to the barrel of the syringe when the magnetic stirrer is mounted in proximity to the barrel of the syringe.

5. The sonothrombolysis infusion system of Claim 3, wherein the magnetic stirrer further comprises a motor, coupled to the rod, to rotate the rod at a selectable speed of rotation.

6. The sonothrombolysis infusion system of Claim 5, wherein the selectable speed of rotation is within the range of 60-200 RPM .

7. The sonothrombolysis infusion system of Claim 5, wherein the selectable speed of rotation is less than 100 RPM.

8. The sonothrombolysis infusion system of Claim 1, wherein the syringe pump further comprises a retention bar retaining the syringe in a mounting position on the syringe pump,

wherein the magnetic stirrer is held in

proximity to barrel of the syringe by the retention bar.

9. The sonothrombolysis infusion system of Claim 8, wherein the retention bar further comprises a spring-loaded retention bar; and

wherein the syringe pump further comprises a release knob coupled to the spring-loaded retention bar .

10. A method for delivering a microbubble solution to a subject for sonothrombolysis treatment comprising :

placing a plurality of magnetic beads in the barrel of a syringe;

filling the barrel of the syringe with a

microbubble solution;

mounting the syringe on a syringe pump;

connecting an infusion tube to the syringe;

mounting a magnetic stirrer in proximity to the barrel of the syringe; and

actuating the syringe pump.

11. The method of Claim 10, wherein filling the barrel of the syringe with a microbubble solution further comprises:

drawing the microbubble solution into the barrel of the syringe through a syringe needle of size 20 gauge or larger; and

removing the needle from the syringe prior to connecting the infusion tube to the syringe.

12. The method of Claim 10, wherein mounting a magnetic stirrer in proximity to the barrel of the syringe further comprises mounting a magnetic stirrer on the syringe; and

retaining the magnetic stirrer on the syringe with a syringe pump retention bar.

13. The method of Claim 1, wherein the magnetic stirrer further comprises a rotating bar having a plurality of magnets thereon,

wherein mounting the magnetic stirrer in

proximity to the barrel of the syringe further comprises mounting the magnetic stirrer with the rotating bar substantially parallel to the barrel of the syringe.

14. The method of Claim 1, wherein the magnetic stirrer further comprises a motor coupled to the rotating rod to rotate the rod at a speed of rotation selected to prevent microbubble stratification in the barrel of the syringe while maintaining the integrity of the microbubbles .

15. The method of Claim 10, further comprising priming the infusion tube with microbubble solution.