PATENTSCOPE sera indisponible durant quelques heures pour des raisons de maintenance le lundi 03.02.2020 à 10:00 AM CET
Recherche dans les collections de brevets nationales et internationales
Une partie du contenu de cette demande n'est pas disponible pour le moment.
Si cette situation persiste, contactez-nous auObservations et contact
1. (WO2015179751) ANALYSEUR D'HALEINE ET PROCÉDÉS DE TEST D'HALEINE
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

WHAT IS CLAIMED IS:

1. A handheld, portable breath analyzer, comprising:

a main body; and

a removable mouthpiece, wherein the removable mouthpiece removably attaches to the main body;

wherein the main body includes a sensor, a processor, a power source and an electrical circuit;

wherein the electrical circuit operably connects the power source to the sensor and connects the sensor to the processor;

wherein the sensor comprises a conductive material and hydrogen selective material in contact with the conductive material, wherein the hydrogen selective material has a resistivity that increases in response to increased concentration of hydrogen; and

wherein the processor detects resistivity of the sensor and uses the resistivity to calculate a concentration of hydrogen.

2. The breath analyzer of claim 1 wherein the hydrogen selective material comprises polyaniline, wherein the polyaniline is doped with a dopant that increases pH sensitivity of the polyaniline, and wherein the polyaniline has a resistivity that increases in response to increased concentration of hydrogen.

3. The breath analyzer of claim 2 wherein the polyaniline has a pH sensitivity of more than 59mV.

4. The breath analyzer of claim 2 wherein the dopant comprises a protonic acid.

5. The breath analyzer of claim 4 wherein the dopant comprises a protonic acid selected from the group consisting of hydrochloric acid, sulfuric acid, salicylic acid, acetic acid, citric acid, tartaric acid, oxalic acid, malonic acid, succinic acid, glutamic acid, adipic acid, phthalic acid and camphor sulfonic acid.

6. The breath analyzer of claim 5 wherein the dopant consists essentially of hydrochloric acid.

7. The breath analyzer of claim 1 wherein the conductive comprises a plurality of electrodes.

8. The breath analyzer of claim 7 wherein the plurality of interdigitated finger electrodes.

9. The breath analyzer of claim 1 wherein the hydrogen selective material is deposited as a thin film on the conductive material.

10. The breath analyzer of claim 1 further comprising a desiccant or gas filter, wherein the desiccant or gas filter is located in either the removable mouthpiece or the main body.

11. A breath test method for screening for a gastrointestinal disorder, comprising steps of: (a) providing a portable, hand-held breath analyzer, wherein the portable, hand-held breath analyzer comprises:

(i) a main body; and

(ii) a removable mouthpiece, wherein the removable mouthpiece removably attaches the main body, wherein the main body includes a sensor, a processor, a power source and an electrical circuit, wherein the electrical circuit operably connects the power source to the sensor and connects the sensor to the processor; wherein the sensor comprises a conductive material and hydrogen selective material in contact with the conductive material, wherein the hydrogen selective material has a resistivity that increases in response to increased concentration of hydrogen;

(b) prompting a subject to exhale a breath sample into the removable mouthpiece;

(c) allowing the processor to measure a resistivity of the sensor that occurs when the breath sample contacts the sensor; and

(f) designating the subject as having an increased likelihood of having a gastrointestinal disorder if the measured resistivity is above and/or beneath a predetermined value.

12. The breath test method of claim 11 wherein the gastrointestinal disorder is celiac disease.

13. The breath test method of claim 11 wherein the gastrointestinal disorder is non-celiac gluten sensitivity.

14. A breath test method for diagnosing a gastrointestinal disorder, comprising steps of:

(a) providing a portable, hand-held breath analyzer, wherein the portable, hand-held breath analyzer comprises:

(i) a main body; and

(ii) a removable mouthpiece, wherein the removable mouthpiece removably attaches the main body, wherein the main body includes a sensor, a processor, a power source and an electrical circuit, wherein the electrical circuit operably connects the power source to the sensor and connects the sensor to the processor; wherein the sensor comprises a conductive material and hydrogen selective material in contact with the conductive material, wherein the hydrogen selective material has a resistivity that increases in response to increased concentration of hydrogen;

(b) prompting a subject to exhale a breath sample into the removable mouthpiece;

(c) allowing the processor to measure a resistivity of the sensor that occurs when the breath sample contacts the sensor; and

(f) diagnosing the subject as having a gastrointestinal disorder if the measured resistivity is above and/or beneath a predetermined value.

15. The breath test method of claim 14 wherein the gastrointestinal disorder is celiac disease.

16. The breath test method of claim 14 wherein the gastrointestinal disorder is non-celiac gluten sensitivity.

17. A breath test method for screening for lactose intolerance, comprising steps of:

(a) providing a portable, hand-held breath analyzer, wherein the portable, hand-held breath analyzer comprises:

(i) a main body; and

(ii) a removable mouthpiece, wherein the removable mouthpiece removably attaches the main body, wherein the main body includes a sensor, a processor, a power source and an electrical circuit, wherein the electrical circuit operably connects the power source to the sensor and connects the sensor to the processor; wherein the sensor comprises a conductive material and hydrogen selective material in contact with the conductive material, wherein the hydrogen selective material has a resistivity that increases in response to increased concentration of hydrogen;

(a) prompting a subject to exhale a baseline breath sample into the removable mouthpiece;

(b) allowing the processor to measure a resistivity of the sensor that occurs when the baseline breath sample contacts the sensor;

(c) prompting a subject to ingest a lactose-containing meal;

(d) prompting a subject to exhale a post-lactose breath sample into the removable mouthpiece;

(e) allowing the processor to measure a resistivity of the sensor that occurs when the post-lactose breath sample contacts the sensor;

(f) comparing the measured resistivity of the baseline breath sample to the measured resistivity of the post-lactose breath sample;

(g) designating the subject as having an increased likelihood of having lactose intolerance if the comparing meets a predetermined criterion.

18. The breath test method of claim 16 wherein the designating the subject as having an increased likelihood of having lactose intolerance occurs when the measured resistivity is above and/or beneath a predetermined value.

19. The breath test method of claim 17, comprising:

(a) prompting a subject to exhale a first post-lactose breath sample into the removable mouthpiece at a first time point;

(e) allowing the processor to measure a resistivity of the sensor that occurs when the first post-lactose breath sample contacts the sensor;

(a) prompting a subject to exhale a second post-lactose breath sample into the removable mouthpiece at a second time point;

(e) allowing the processor to measure a resistivity of the sensor that occurs when the second post-lactose breath sample contacts the sensor;

(f) comparing the measured resistivity of the baseline breath sample, the first post-lactose breath sample and the second post-lactose breath sample;

(g) designating the subject as having an increased likelihood of having lactose intolerance if the comparing meets a predetermined criterion.

20. The breath test method of claim 19, comprising:

(a) prompting a subject to exhale a first post-lactose breath sample into the removable mouthpiece at a first time point;

(b) allowing the processor to measure a resistivity of the sensor that occurs when the first post-lactose breath sample contacts the sensor;

(c) prompting a subject to exhale a second post-lactose breath sample into the removable mouthpiece at a second time point;

(d) allowing the processor to measure a resistivity of the sensor that occurs when the second post-lactose breath sample contacts the sensor;

(e) prompting a subject to exhale a third post-lactose breath sample into the removable mouthpiece at a third time point;

(f) allowing the processor to measure a resistivity of the sensor that occurs when the third post-lactose breath sample contacts the sensor;

(g) prompting a subject to exhale a fourth post-lactose breath sample into the removable mouthpiece at a fourth time point;

(h) allowing the processor to measure a resistivity of the sensor that occurs when the fourth post-lactose breath sample contacts the sensor;

(i) comparing the measured resistivity of the baseline breath sample, the first post-lactose breath sample, the second post-lactose breath sample, the third post-lactose breath sample and the fourth post-lactose breath sample; and

j) designating the subject as having an increased likelihood of having lactose intolerance if the comparing meets a predetermined criterion.

21. The breath test method of claim 20 wherein the first time point is a 30 minute time point, the second time point is a 60 minute time point, the third time point is a 90 minute time point and the fourth time point is a 120 minute time point.

22. A breath test method for screening for fructose intolerance, comprising steps of:

(a) providing a portable, hand-held breath analyzer, wherein the portable, hand-held breath analyzer comprises:

(i) a main body; and

(ii) a removable mouthpiece, wherein the removable mouthpiece removably attaches the main body, wherein the main body includes a sensor, a processor, a power source and an electrical circuit, wherein the electrical circuit operably connects the power source to the sensor and connects the sensor to the processor; wherein the sensor comprises a conductive material and hydrogen selective material in contact with the conductive material, wherein the hydrogen selective material has a resistivity that increases in response to increased concentration of hydrogen;

(a) prompting a subject to exhale a baseline breath sample into the removable mouthpiece;

(b) allowing the processor to measure a resistivity of the sensor that occurs when the baseline breath sample contacts the sensor;

(c) prompting a subject to ingest a fructose-containing meal;

(d) prompting a subject to exhale a post- fructose breath sample into the removable mouthpiece;

(e) allowing the processor to measure a resistivity of the sensor that occurs when the post-fructose breath sample contacts the sensor;

(f) comparing the measured resistivity of the baseline breath sample to the measured resistivity of the post-fructose breath sample;

(g) designating the subject as having an increased likelihood of having fructose intolerance if the comparing meets a predetermined criterion.

23. The breath test method of claim 22 wherein the designating the subject as having an increased likelihood of having fructose intolerance occurs when the measured resistivity is above and/or beneath a predetermined value.

24. The breath test method of claim 22, comprising:

(a) prompting a subject to exhale a first post- fructose breath sample into the removable mouthpiece at a first time point;

(e) allowing the processor to measure a resistivity of the sensor that occurs when the first post-fructose breath sample contacts the sensor;

(a) prompting a subject to exhale a second post- fructose breath sample into the removable mouthpiece at a second time point;

(e) allowing the processor to measure a resistivity of the sensor that occurs when the second post-fructose breath sample contacts the sensor;

(f) comparing the measured resistivity of the baseline breath sample, the first post-fructose breath sample and the second post-fructose breath sample;

(g) designating the subject as having an increased likelihood of having fructose intolerance if the comparing meets a predetermined criterion.

25. The breath test method of claim 24, comprising:

(a) prompting a subject to exhale a first post- fructose breath sample into the removable mouthpiece at a first time point;

(b) allowing the processor to measure a resistivity of the sensor that occurs when the first post-fructose breath sample contacts the sensor;

(c) prompting a subject to exhale a second post- fructose breath sample into the removable mouthpiece at a second time point;

(d) allowing the processor to measure a resistivity of the sensor that occurs when the second post-fructose breath sample contacts the sensor;

(e) prompting a subject to exhale a third post-fructose breath sample into the removable mouthpiece at a third time point;

(f) allowing the processor to measure a resistivity of the sensor that occurs when the third post-fructose breath sample contacts the sensor;

(g) prompting a subject to exhale a fourth post- fructose breath sample into the removable mouthpiece at a fourth time point;

(h) allowing the processor to measure a resistivity of the sensor that occurs when the fourth post-fructose breath sample contacts the sensor;

(i) comparing the measured resistivity of the baseline breath sample, the first post-fructose breath sample, the second post-fructose breath sample, the third post-fructose breath sample and the fourth post-fructose breath sample; and

(j) designating the subject as having an increased likelihood of having fructose intolerance if the comparing meets a predetermined criterion.

26. The breath test method of claim 25 wherein the first time point is a 30 minute time point, the second time point is a 60 minute time point, the third time point is a 90 minute time point and the fourth time point is a 120 minute time point.