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1. (WO2015179282) COMPOSITIONS TOPIQUES COMPRENANT UNE THIAZOLIDINEDIONE
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

Claims

What is claimed is:

1. A composition comprising:

a. a thiazolidinedione selected from the group consisting of rosiglitazone,

pioglitazone, troglitazone, ciglitazone, netoglitazone, rivoglitazone, and pharmaceutically acceptable salts thereof; and

b. a vehicle comprising oleic acid and a monohydroxy alcohol.

2. The composition of claim 1, wherein the monohydroxy alcohol is selected from the group consisting of methanol, ethanol, isopropanol, and w-propanol.

3. The composition of claim 2, wherein the monohydroxy alcohol is ethanol.

4. The composition of claim 2, wherein the monohydroxy alcohol is isopropanol.

5. The composition of claim 1, wherein the solubility of the thiazolidinedione in the vehicle is at least 1 part thiazolidinedione or pharmaceutically acceptable salt thereof per 3000 parts of vehicle.

6. The composition of claim 5, wherein the solubility of the thiazolidinedione in the vehicle is at least 1 part thiazolidinedione or pharmaceutically acceptable salt thereof per 1000 parts of vehicle.

7. The composition of claim 6, wherein the solubility of the thiazolidinedione in the vehicle is at least 1 part thiazolidinedione or pharmaceutically acceptable salt thereof per 300 parts of vehicle.

8. The composition of claim 7, wherein the solubility of the thiazolidinedione in the vehicle is at least 1 part thiazolidinedione or pharmaceutically acceptable salt thereof per 100 parts of vehicle.

9. The composition of claim 1, wherein the concentration of the thiazolidinedione is between about 0.03% and about 1% of the total weight of the composition.

10. The composition of claim 1, wherein the thiazolidinedione is rosiglitazone or a pharmaceutically acceptable salt thereof.

11. The composition of claim 10, wherein the thiazolidinedione is rosiglitazone maleate.

12. The composition of claim 1, wherein the thiazolidinedione is pioglitazone or a pharmaceutically acceptable salt thereof.

13. The composition of claim 10, wherein the thiazolidinedione is pioglitazone hydrochloride.

14. The composition of claim 1, wherein the concentration of the oleic acid is between about 1% and about 5% of the total weight of the composition.

15. The composition of claim 1, wherein the concentration of the monohydroxy alcohol is between about 50% and about 80% of the total weight of the composition.

16. The composition of claim 1, further comprising propylene glycol.

17. The composition of claim 16, wherein the concentration of the propylene glycol is between about 20% and about 30% of the total weight of the composition.

18. The composition of claim 1, further comprising glycerin.

19. The composition of claim 1, further comprising water.

20. A process for preparing a topical composition, comprising the steps of: (1) combining oleic acid and a monohydroxy alcohol and optionally one or more other compounds to form a first mixture; and (2) combining a TZD or pharmaceutically acceptable salt thereof in the first mixture to provide a second mixture.

21. The process of claim 20, further comprising the step of adding a viscosity-enhancing agent to the mixture.

22. The process of claim 20, wherein the monohydroxy alcohol is selected from the group consisting of methanol, ethanol, isopropanol, and w-propanol.

23. The process of claim 22, wherein the monohydroxy alcohol is ethanol.

24. The process of claim 22, wherein the monohydroxy alcohol is isopropanol.