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1. (WO2015177367) NOUVEAUX COMPOSÉS UTILES EN TANT QU'INHIBITEURS DE S100
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

Claims

1. A compound of formula (I)


or a pharmaceutically acceptable salt thereof,

wherein

RA, RB and Rc are independently selected from H, halogen, cyano, RiO, C1 -C6 alkyl optionally substituted by RiO, C3-C6 cycloalkyl optionally substituted by RiO, R2C(0), R3S, R4S(0)2, R5OC(0), (R6ON)C(R7), R8R9NC(0), RioRnN, Ri2S(0)2NRi3, Ri4S(0)2NRi5C(0), phenyl optionally substituted by one or more moieties Ri6, and 5- or 6-membered heterocyclyl optionally substituted by one or more moieties Ri6, or

one of RA and Rc together with RB forms a biradical -(CH2)m- wherein m is an integer of from 3 to 5, and the other one of RA and Rc is selected from H, halogen, cyano, RiO, C1-C6 alkyl optionally substituted by RiO, C3-C6 cycloalkyl optionally substituted by RiO, R2C(0), R3S, R4S(0)2, R5OC(0), (R6ON)C(R7), R8R9NC(0), RioRnN, Ri2S(0)2NRi3, Ri4S(0)2NRi5C(0), phenyl optionally substituted by one or more moieties Ri6, and 5- or 6-membered heterocyclyl optionally substituted by one or more moieties Ri6;

each Ri6 is independently selected from halogen, cyano, nitro, Ri70, C1 -C6 alkyl optionally substituted by Ri70, C3-C6 cycloalkyl optionally substituted by Ri70, R18C(0), R19S, R2oS(0)2, R2iOC(0), (R22ON)C(R23), R24R25NC(0), R26R27N, R28S(0)2NR29, and R30S(O)2NR3iC(O);

each one of Ri-R3i is independently selected from H, C1-C6 alkyl, and C3-C6 cycloalkyl;

W is a direct bond or Xi-X2-X3;

Xi is C1 -C2 alkylene, optionally substituted by C1-C4 alkyl or R320;

X2 is O or is absent;

X3 is a direct bond or C1-C2 alkylene, optionally substituted by C1-C4 alkyl or R320;

R32 is selected from H and C1-C4 alkyl;

RD is C1-C6 alkyl, or a cyclic moiety selected from phenyl, 4- to 6-membered heterocyclyl, and C4-C6 cycloalkyl, wherein said cyclic moiety is optionally substituted by one or more R33;

each R33 is independently selected from halogen, cyano, C1-C6 alkyl optionally substituted by R340, C3-C6 cycloalkyl, phenyl, 5- or 6-membered heterocyclyl, R340, R35OC(0), R36S(0)2, R37C(0), R38R39 , R4oR4i (CO); or two R33, attached to one and the same carbon atom may form, together with the carbon atom to which they are both attached, a 4- to 6-membered ring optionally containing one more heteroatoms in the ring;

R34 is independently selected from H, C1-C6 alkyl, and C3-C6 cycloalkyl; wherein said alkyl or cycloalkyl is optionally substituted by R42O;

each one of R35-R36 is independently selected from H, C1 -C6 alkyl, and C3-C6 cycloalkyl;

R37 is independently selected from C1-C6 alkyl, and C3-C6 cycloalkyl, wherein said alkyl or cycloalkyl is optionally substituted by R430;

R38 and R39 are independently selected from H, C1-C6 alkyl, and C3-C6 cycloalkyl, wherein said alkyl or cycloalkyl is optionally substituted by R44R45N or R46O, or

R38 and R39 together with the nitrogen atom to which they are both attached, form a 4- to 6-membered heterocyclic ring optionally containing one or more further heteroatoms and optionally substituted by C1 -C6 alkyl;

R40 and R41 are independently selected from H, C1-C6 alkyl, and C3-C6 cycloalkyl, wherein said alkyl or cycloalkyl is optionally substituted by RnR4sN or R49O, or

R40 and R41 together with the nitrogen atom to which they are both attached, form a 4- to 6-membered heterocyclic ring optionally containing one or more further heteroatoms and optionally substituted by C1 -C6 alkyl;

R44 and R45 are independently selected from H, CI -C6 alkyl, and C3-C6 cycloalkyl, or

R44 and R45 together with the nitrogen atom to which they are both attached, form a 4- to 6-membered saturated heterocyclic ring optionally containing one or more further heteroatoms and optionally substituted by C1-C6 alkyl;

R47 and R48 are independently selected from H, CI -C6 alkyl, and C3-C6 cycloalkyl, or

R47 and R48 together with the nitrogen atom to which they are both attached, form a 4- to 6-membered saturated heterocyclic ring optionally containing one or more further heteroatoms and optionally substituted by C1-C6 alkyl;

R42, R43, R46 and R49 are independently selected from H, C1-C6 alkyl, and C3-C6 cycloalkyl;

any alkyl is optionally substituted by one or more F.

2. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein RD is a cyclic moiety selected from phenyl, 4- to 6-membered heterocyclyl, and C4-C6 cycloalkyl, wherein said cyclic moiety is optionally substituted by one or more R33.

3. The compound of claim 1 or claim 2, or a pharmaceutically acceptable salt thereof, wherein RD is a cyclic moiety selected from 4- to 6-membered heterocyclyl, wherein said cyclic moiety is optionally substituted by one or more R33.

4. The compound of any one of the claims 1 to 3, or a pharmaceutically acceptable salt thereof, wherein RD is a cyclic moiety selected 5- to 6-memberedheteroaryl, wherein said cyclic moiety is optionally substituted by one or more R33.

5. The compound of claim 1 or claim 2, or a pharmaceutically acceptable salt thereof, wherein RD is a cyclic moiety selected from C4-C6 cycloalkyl, wherein said cyclic moiety is optionally substituted by one or more R33.

6. The compound of claim 1 or claim 2, or a pharmaceutically acceptable salt thereof, wherein RD is phenyl optionally substituted by one or more R33.

7. The compound of any one of the claims 1 to 6, or a pharmaceutically acceptable salt thereof, wherein RA, RB and Rc are independently selected from H, halogen, C1-C4 alkyl and R2C(0).

8. The compound of any one of the claims 1 to 6, or a pharmaceutically acceptable salt thereof, wherein one of RA, RB and Rc is phenyl optionally substituted by one or more moieties Ri6, or 5-or 6-membered heterocyclyl optionally substituted by one or more moieties Ri6, and the two others of RA, RB and Rc are independently selected from H, halogen, and C1-C4 alkyl.

9. The compound of any one of the claims 1 to 8, or a pharmaceutically acceptable salt thereof, wherein W is a direct bond.

10. The compound of any one of the claims 1 to 8, or a pharmaceutically acceptable salt thereof, wherein W is XI -X2-X3.

11. A compound according to claim 1 , selected from

6-chloro-N-[10,l l-dimethyl-4-oxo-3-(trifiuoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca- 1(8),6,9,11 -tetraen-3-yl]-pyridine-2-carboxamide;

N-[10,l 1 -dichloro-4-oxo-3-(trifluorome

tetraen-3-yl]-6-fluoropyridine-2-carboxamide;

N-[4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]- benzamide;

2-cyclohexyl-N-[4-oxo-3-(trifluoromethyl)-2,5,7-tri-azatricyclo[6.4.0.02'^odeca-l(12),6,8,10- tetraen-3-yi]-acetamide;

3-(moφholin-4-yl)-N-[4-oxo-3-(trifluoromethyl)-2,5,7-tri-azatricyclo[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -propanamide;

N-[4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-3-(pyrrolidin-l -yl)propanamide;

3-(oxan-4-yl)-N-[4-oxo-3-(trifluoromethy^^^

tetraen-3-yl] -propanamide;

2- bromo-N-[3-oxo-4-(tri-fluoromethyl)-2,5,7-triaza ricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-4-yl]-benzamide;

3- cyclopentyl-N-[4-oxo-3-(trifluoromet^^^

tetraen-3-yl]-propanamide;

3,5-dimethoxy-N-[3-oxo-4-(trifluoromethyl)-2,5,7-tri-azatricyclo[6.4.0.02'6]dodeca- 1(12), 6,8,10-tetraen-4 -yl] -b enzamide ;

6-methyl-N-[3-oxo-4-(tri-fluorom^

tetraen-4-yl]-pyridine-3-carboxamide;

3,5-dichloro-N-[4-oxo-3-(tri-fluorome

tetraen-3-yl]-benzamide;

3-cyclohexyl-N-[3-oxo-4-(trifluoromethyl)-2,5,7-tri-azatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-4-yl]-propanamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluorom

tetraen-3-yl]-benzamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluorom

tetraen-3 -yl] -3 -phenylpropanamide;

3- (2-chlorophenyl)-N-[10,l l-dimethyl-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(8),6,9,l l -tetraen-3-yl]-propanamide;

3,5-dichloro-N-[10,l l -dimethyl-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(8),6,9,l l -tetraen-3-yl]benzamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluorom

tetraen-3 -yl] -4 -pheny lbenzamide ;

4- cyclopentyl-N-[10,l l-dimethyl-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(8),6,9,l l -tetraen-3-yl]-butanamide

2- cyclohexyl-N-[l 0, 11 -dimethyl-4-oxo-3-(trifluoro-methyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(8),6,9,l l -tetraen-3-yl]-acetamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromeft^^

tetraen-3-yl]-6-(2,2,2-trifluoroethoxy)-pyridine-3-carboxamide;

1 -cyclopentanecarbonyl-N- [10,11 -dimethyl-4-oxo-3 -(trifluoromethyl)-2,5 ,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-pyrrolidine-3-carboxamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -3 -(morpholin-4-yl)propanamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-pyrrolidine-3-carboxamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1( 12), 6,8,10-tetraen-3-yl]-piperidine-4-carboxamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1( 12), 6,8,10-tetraen-3-yl]-l -(2-methoxyacetyl)-piperidine-4-carboxamide;

3- cyclopentyl-N-[ 10,1 1 -dimethyl-4-oxo-3-(trifluoro-methyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-propanamide;

6-chloro-N-[10,l l-dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-pyridine-3-carboxamide;

3-(2,6-dichlorophenyl)-N-[10,l l-dimethyl-4-oxo-3-(tri-fluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(8),6,9,l l -tetraen-3-yl]-propanamide;

2- bromo-N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-1(8),6,9,11 -tetraen-3-yl]-benzamide;

6-(cyclohexylamino)-N-[10,l l-dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-tri-azatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-pyridine-3-carboxamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraen-3 -yl] -6-methylpyridine-3-carboxamide;

3- cyclohexyl-N-[l 0, 11 -dimethyl-3-oxo-4-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-4-yl]-propanamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraen-3 -yl] -3 -(pyridin-3-yl)propanamide;

6-(cyclohexylamino)-N-[ 10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-tri-azatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]pyridine-2-carboxamide;

6-cyclohexyl-N-[l 0, 1 1 -dimethyl-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo- [6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-pyridine-2-carboxamide;

N-[10,l l -dichloro-4 )xo-3-(trifluorom

tetraen-3 -yl] -3 -phenylpropanamide;

N-[ 10, 1 1 -dichloro-4-oxo-3-(trifluoromethyl)-2 ,5 ,7-triaza-tricyclo [6.4.0.02'6]dodeca- 1 (8),6,9,1 1 -tetraen-3-yl]-benzamide;

3-cyclopentyl-N-[ 10,l l -di-chloro-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-propanamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-2-azaspiro[3.3]heptane-6-carboxamide;

(2S)-N-[ 10, 1 1 -dichloro-4-oxo-3-(trifluoromethyl)-2,5 ,7-triazatricyclo-[6.4.0.02' 6]dodeca-1( 12), 6,8,10-tetraen-3-yl]pyrrolidine-2-carboxamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-tri-azatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-pyrrolidine-3-carboxamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-tri-azatricyclo[6.4.0.02'6]dodeca-1( 12), 6,8,10-tetraen-3-yl]-piperidine-4-carboxamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-tri-azatricyclo[6.4.0.02'6]dodeca-1( 12), 6,8,10-tetraen-3-yl]-l -(2-methoxyacetyl)-piperidine-4-carboxamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraen-3 -yl] - 1 -(3-methylbutanoyl)-piperidine-4-carboxamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-l -(3,3,3-trifluoropropanoyl)-piperidine-4-carboxamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-azetidine-3-carboxamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca- 1( 12), 6,8,10-tetraen-3-yl]-l -(ethanesulfonyl)azetidine-3-carboxamide;

l -acetyl-N-[ 10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-azetidine-3-carboxamide;

l-cyclopentanecarbonyl-N-[10,l l-dichloro-4-oxo-3-(tri-fluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-pyrrolidine-3-carboxamide;

(3R)- 1 -(cyclopentane-sulfonyl)-N-[ 10,11 -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l (12),6,8,10-tetraen-3-yl]-pyrrolidine-3-carboxamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-tri-azatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-l -(pyridin-2-yl)azetidine-3-carboxamide;

3-cyclohexyl-N-[10,l l-dichloro-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-propanamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-tri-azatricyclo[6.4.0.02'6]dodeca-1( 12), 6,8,10-tetraen-3-yl]-cyclopentanecarboxamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-tri-azatricyclo[6.4.0.02'6]dodeca-1( 12), 6,8,10-tetraen-3-yl]-cyclohexanecarboxamide;

3-chloro-N-[10,l l-dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-1(12), 6,8,10-tetraen-3 -yl] -b enzamide ;

3,5-dichloro-N-[ 10,11 -di-chloro-4-oxo-3-(trifluoro-methyl)-2,5 ,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-benzamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca- 1 ( 12), 6,8 , 10-tetraen-3 -yl] -4-(pyrrolidin- 1 -yl)butanamide

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraen-3 -yl] -4-(morpholin-4-yl)butanamide

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-2-(morpholin-4-yl)acetamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -3 -(morpholin-4-yl)propanamide;

6-chloro-N-[10,l l-dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-1( 12), 6,8,10-tetraen-3-yl]-pyridine-2-carboxamide;

6-(azetidin-l -yl)-N-[10,l l-dichloro-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo- [6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-pyridine-2-carboxamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-6-(2,2,2-trifluoroethoxy)-pyridine-2-carboxamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca- 1 ( 12), 6,8 , 10-tetraen-3 -yl] -6-(dimethylamino)pyridine-2-carboxamide;

6-(cyclohexylamino)-N-[10,l l-dichloro-4-oxo-3-(tri-fluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-pyridine-2-carboxamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-6-(ethylamino)pyridine-2-carboxamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-2-(piperidin-4-yl)acetamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraen-3 -yl] -3 -(piperidin-2-yl)propanamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-6-(ethylamino)pyridine-2-carboxamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-6-[(2-methoxyethyl)amino]-pyridine-2-carboxamide;

N-[10,l l -difluoro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca- 1(12), 6,8,10-tetraen-3 -yl] -b enzamide ;

3-cyclopentyl-N-[10,l l-difluoro-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-propanamide;

2- cyclohexyl-N-[l 0, 11 -difluoro-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(8),6,9,l l -tetraen-3-yl]-acetamide;

N-[10,l l -dimethoxy-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1(12), 6,8,10-tetraen-3 -yl] -b enzamide ;

3- cyclopentyl-N-[ 10,1 1 -dimethoxy-4-oxo-3-(trifluoromethyl)-2,5 ,7-triaza-tricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-propanamide;

N-[9-bromo-10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-1(8),6,9,11 -tetraen-3-yl]-benzamide;

3-cyclopentyl-N-[ 12-oxo-l 1 -(trifluoromethyl)- 10, 13,15-triazatetracyclo-[7.6.0.03'7.010'14]pentadeca-l(9),2,7,14-tetraen-l l-yl]-propanamide;

N-[10-chloro-4-oxo-3-(tri-fluoromethyl)-2,5,7-triaza ricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

N-[l l-chloro-4-oxo-3-(tri-fluoromethyl)-2,5,7-triaza ricyclo[6.4 2'6]dodeca-l(12),6,8,10-tetraen-3-yl]-3-cyclopentylpropanamide;

3-cyclopentyl-N-[9,10-dimethyl-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-propanamide;

3-cyclopentyl-N-[9-methyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -propanamide;

3-cyclopentyl-N-[9,10-difluoro-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo- [6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-propanamide;

3-cyclopentyl-N-[9,10-di-chloro-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo- [6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-propanamide;

3-cyclopentyl-N-[9,l l -di-chloro-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo- [6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-propanamide;

N-[9-chloro-4-oxo-3-(tri-fluoromethyl)-2,5,7-triaza ricyclo[6.4 2'Vodeca-l(12),6,8,10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

3-cyclopentyl-N-[9,l l -di-fluoro-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-propanamide;

N-[10,l 1 -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l (12),6,8,10-tetraen-3 -yl] oxane -4 -carboxamide ;

N-[10,l 1 -dichloro-4-oxo-3-(trifluorome

tetraen-3 -yl] -3 -( 1 -hydro xycyclopentyl)propan-amide

(2S)-N-[10,l l-dimethyl-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-1(8),6,9,11 -tetraen-3 -yl]-l-methane-sulfonylpyrrolidine -2 -carboxamide;

N-[10,l l -dichloro-4-oxo-3-(trifluorome ^

tetraen-3 -yl] -6 - [(3 -methoxypropyl)-amino] -pyridine -2 -carboxamide;

N-[10,l 1 -dichloro-4-oxo-3-(trifluorom

tetraen-3-yl]-6-[(2-hydroxyethyl)amino]pyridine-2-carboxamide;

N-[10,l l -dichloro-4-oxo-3-(trifluorome ^

tetraen-3-yl]-6-{[(2S)-l-methoxypropan-2-yl]amino}pyridine-2-carboxamide;

N-[10,l 1 -dichloro-4-oxo-3-(trifluorom

tetraen-3-yl]-6-{[2-(dimethylamino)-ethyl]amino-pyridine-2-carboxamide;

N-[10,l 1 -dichloro-4-oxo-3-(trifluorom

tetraen-3-yl]-6-[(2-methoxyethyl)(methyl)amino]-pyridine-2-carboxamide;

methyl 6- { [10,1 l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]-dodeca- 1(8),6,9,1 1 -tetraen-3-yl]carbamoyl}pyridine-2-carboxylate;

2- N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1(8),6,9,1 l -tetraen-3-yl]-6-N-(2-methoxyethyl)pyridine-2,6-dicarboxamide;

N-[10,l 1 -dicmoro-4-oxo-3-(trifluorome

tetraen-3-yl]-6-(hydroxymethyl)pyridine-2-carboxamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1(12), 6, 8,10-tetraen-3 -yl] -3 -fluorobenzamide;

N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1(12), 6,8,10-tetraen-3 -yl] -3,5 -difluorobenzamide ;

3- cyano-N-[10, l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]-dodeca-1(8),6,9,1 1 -tetraen-3-yl]benzamide;

N-[10,l l -dichloro-4 )xo-3-(trifluoro^

tetraen-3-yl]-2-[(2-methoxyethyl)amino]-l ,3-thiazole-4-carboxamide;

N-[10,l 1 -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l (12),6,8,10-tetraen-3-yl]-l -(2,2-difluoroethyl)azetidine-3-carboxamide;

N-[10,l 1 -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l (8),6,9,1 1 -tetraen-3-yl]-3-fluoroazetidine-3-carboxamide;

N-[10,l l -dichloro-4 )xo-3-(trifluoro^

tetraen-3-yl]-3-(3,3-difluoroazetidin-l -yl)-propanamide;

3-(3,3-difluoroazetidin-l -yl)-N-[ 10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-l (8),6,9,l l -tetraen-3-yl]-propanamide;

3-cyclobutyl-N-[ 10,1 1 -dimethyl-4-oxo-3-(trifluoro-methyl)-2,5 ,7-triazatricyclo- [6.4.0.02'6]dodeca-l(8),6,9,l l -tetraen-3-yl]propanamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluorom

tetraen-3 -yl] -3 -( 1 -hydro xycyclopentyl)propan-amide

2-cyclopentyl-N-[ 10,l l -dimethyl-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(8),6,9,l l -tetraen-3-yl]acetamide;

N-[10,l 1 -dimethyl-4-oxo-3-(trifluoro

tetraen-3 -yl] -3,5 -difluorobenzamide ;

N-[10,l 1 -dimethyl-4-oxo-3-(trifluorom

tetraen-3-yl]-6-fluoropyridine-2-carboxamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluorome ^

tetraen-3-yl]-6-[(2-methoxyethyl)amino]pyridine-2-carboxamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluorome ^

tetraen-3 -yl] -2 -phenylacetamide;

2- (3 ,5-dichlorophenyl)-N- [ 10, 11 -dimethyl-4-oxo-3-(trifluoromethyl)-2 ,5 ,7-triazatricyclo[6.4.0.02'6]dodeca-l(8),6,9,l l -tetraen-3-yl]acetamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraen-3 -yl] -3 -(3 ,4,5-trimethoxyphenyl)-propanamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluorome ^

tetraen-3-yl]-3-methanesulfonylbenzamide;

3- bromo-N-[10,l 1 -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(8),6,9,l 1 -tetraen-3 -yl]benzamide

N-[10,l l -dimethyl-4-oxo-3-(trifluorome ^

tetraen-3 -yl] -3 - [(2 -methoxyethyl)amino]benz-amide

2-bromo-N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(8 ),6,9,11 -tetraen-3 -yl]-l ,3-thiazole-4-carboxamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluorome ^

tetraen-3-yl]-2-[(2-methoxyethyl)amino]-l ,3-thiazole-4-carboxamide;

N-[9-bromo-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4 2'6]dodeca-l(12),6,8,10-tetraen-3-yl]-3-cyclopentyl-propanamide;

N-[9-cyano-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]-dodeca-l (12),6,8,10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

N-[9-acetyl-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-3-cyclopentyl-propanamide;

N-[10-chloro-9-cyano-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

3-cyclopentyl-N-[9-fluoro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]-dodeca-1( 12), 6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[9,l l -dimethyl-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

N-[9-chloro-10-fluoro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

N-[10-chloro-9-methyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]-dodeca-1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

3-cyclopentyl-N-[4-oxo-3,9-bis(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]-dodeca-1(8),6,9,11 -tetraen-3-yl]propanamide;

N-[l l-bromo^-oxo-3,9-bis-(trifluoro^

tetraen-3 -yl] -3 -cyclopentylpropanamide;

N-[10-chloro-9-fluoro-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

3-cyclopentyl-N-[9-fluoro-10-methoxy-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[9-(methyl-sulfanyl)-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[9-methane-sulfonyl-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

N-[9-bromo-10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

N-[9,10-dichloro-4-oxo-3-(trifluoro methyl

tetraen-3-yl]-6-fluoropyridine-2-carboxamide;

N-[9,10-dichloro-4-oxo-3-(trifluoro methyl

tetraen-3-yl]-6-[(2-methoxyethyl)amino]-pyridine-2-carboxamide;

N-[10-chloro-9-cyano-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1(8),6,9,11 -tetraen-3-yl]-6-fluoropyridine-2-carboxamide;

N-[10-chloro-9-cyano-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1(8),6,9,1 l -tetraen-3-yl]-6-[(2-methoxyethyl)amino]-pyridine-2-carboxamide;

N-[10-chloro-9-cyano-4-oxo-3-(trifluoromethyl)-2,5,7-triazat-ricyclo[6.4.0.02'6]dodeca- 1(8),6,9,1 1 -tetraen-3-yl]-2-[(2-methoxyethyl)amino]-l ,3-thiazole-4-carboxamide;

N-[10-chloro-9-cyano-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca- 1(8),6,9,1 l -tetraen-3-yl]-6- {[(2S)-l -methoxypropan-2-yl]amino}pyridine-2-carboxamide;

N-[9,10-difluoro-4-oxo-3-(trifluoromethyl)-2,^

tetraen-3-yl]-6-fluoropyridine-2-carboxamide;

N-[9,10-difluoro-4-oxo-3-(trifluorome ^^

tetraen-3 -yl] -6 - [(2 -methoxyethyl)amino] -pyridine-2 -carboxamide;

(2S)-N-[ 10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triaza-tricyclo[6.4.0.02'6]dodeca-1(8),6,9,1 1 -tetraen-3-yl]-2-phenylpropanamide;

(2S)-N-[ 10,l l -dimethyl-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-1(8),6,9,1 1 -tetraen-3-yl]-2-phenyl-propanamide;

(2S)-3-cyclopentyl-N-[10,l l -dimethyl-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-l(8),6,9,l l -tetraen-3-yl]-2-methyl-propanamide;

(2S)-N-[10,l l -dimethyl-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[64 2'6]dodeca-1(8),6,9,1 1 -tetraen-3-yl]-2-hydroxy-2-phenylacetamide;

(2S)-N-[ 10,l l -dimethyl-4-oxo-3-(trifluoro-methyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca- 1(8),6,9,1 1 -tetraen-3-yl]-2-methoxy-2-phenylacetamide;

methyl 3-(3-cyclopentylpropanamido)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l (12),6,8,10-tetraene-9-carboxylate;

3-cyclopentyl-N-[9-iodo-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca- 1( 12), 6,8,10-tetraen-3-yl]propanamide;

N-[9-bromo-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l (12),6,8,10-tetraen-3 -yl] -2 -methoxypyridine-3 -carboxamide;

N-[9-bromo-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l (12),6,8,10-tetraen-3-yl]-2-hydroxypyridine-3-carboxamide;

(2S)-N-[9-bromo-4-oxo-3-(trifluorome

tetraen-3 -yl] -2 -cyclohexylpropanamide;

(2S)-2-(cyclopent-l -en-l -ylmethoxy)-N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l (12),6,8,10-tetraen-3-yl]propanamide;

N-[l l-chloro-9-iodo-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1(12), 6, 8,10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

N-[9-bromo-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3 -yl]butanamide

N-[9-bromo-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-2-(cyclopentylamino)-l ,3-thiazole-4-carboxamide;

3-cyclopentyl-N-[9-iodo-10-methoxy-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[9-(hydroxymethyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

N-[9-butyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l (12),6,8,10-tetraen-3-yl]-3-cyclopentylpropanamide;

3-(3-cyclopentylpropanamido)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraene-9-carboxylic acid;

3-cyclopentyl-N-{9-[l -(methoxyimino)ethyl]-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl}propanamide;

3-(3-cyclopentylpropanamido)-N-methyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraene-9-carboxamide;

3-cyclopentyl-N-[9-ethynyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1( 12), 6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[4-oxo-9-(trifluoromethoxy)-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[9-cyclopropanesulfonamido-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-(3-cyclopentylpropanamido)-N-methanesulfonyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraene-9-carboxamide;

3-cyclopentyl-N-[9-methanesulfonamido-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

N-[9-bromo-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-2-[(2-methoxyethyl)amino]-l ,3-thiazole-4-carboxamide;

N-[9-acetyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[64.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-2-[(2-methoxyethyl)amino]-l ,3-thiazole-4-carboxamide;

3-(3,3-difluoropyrrolidin- 1 -yl)-N-[ 10,1 1 -dimethyl-4-oxo-3-(trifluoromethyl)-2,5 ,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca- 1 ( 12), 6,8 , 10-tetraen-3 -yl] -3 -(3-fluoroazetidin- 1 -yl)propanamide;

3-(3,3-difluoropiperidin-l -yl)-N-[10,l l-dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

N-[9-acetyl-10,l l-dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca- 1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraen-3 -yl] -2-methoxypyridine-3-carboxamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraen-3 -yl] -2-hydroxypyridine-3-carboxamide;

N-[l l-bromo-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[64.0.02'6]dodeca-l(12),6,8,10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

N-[10-bromo-9-fluoro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

N-[9-bromo-10-methoxy-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

3-cyclopentyl-N-[9-fluoro-10-(l-hydroxyethyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

N-[9-acetyl-10-methoxy-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

N-[9-bromo-l l-chloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

N-[9-acetyl-l l -chloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

N-[l l-bromo-9-fluoro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

N-[l l-acetyl-4-oxo-3,9-bis(trifluorom^

tetraen-3 -yl] -3 -cyclopentylpropanamide;

N-[l l-chloro-10-methoxy-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca- 1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

3-cyclopentyl-N-[9-(4-methoxyphenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[9-(l -methyl-lH-pyrazol-4-yl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[9-(6-methoxypyridin-3-yl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[9-(3-methoxyphenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[9-(l ,3-oxazol-2-yl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

N-[9-(4 ert-butylphenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca- 1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

N-[9-(4-cyanophenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

3-cyclopentyl-N-[9-(4-nitrophenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

N-[9-(4-aminophenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

3-cyclopentyl-N-[4-oxo-9-phenyl-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1( 12), 6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[9-(2-methoxyphenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

2- hydroxy-N-[9-(4-methoxyphenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]pyridine-3-carboxamide;

3- cyclopentyl-N-[9-(2-hydroxyphenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[4-oxo-9-(lH-l,2,3,4-tetrazol-5-yl)-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-[3-(3-cyclopentylpropanamido)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-9-yl]benzoic acid;

N-[9-(4-chlorophenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca- 1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

3-cyclopentyl-N-[9-(4-methylphenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[9-(3,4-dichlorophenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[9-(3,4-dihydro-2H-pyran-5-yl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[ 10,1 1 -dimethyl-9-( 1 -methyl- 1 H-pyrazol-4-yl)-4-oxo-3 -(trifluoromethyl)- 2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[ 10,1 1 -dimethyl-4-oxo-9-(l ,2-thiazol-4-yl)-3-(trifluoromethyl)-2,5 ,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[9-(furan-3-yl)-10,l l-dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

N-[9-(4-methoxyphenyl)-10,l l-dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]acetamide;

3-cyclopentyl-N-[9-fluoro-10-(4-methoxyphenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[l l -(4-methoxyphenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

(2S)-N-[10,l l-dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca- 1 ( 12), 6,8 , 10-tetraen-3 -yl] -2-(3-methylbutoxy)propanamide;

(2R)-N-[ 10,1 1 -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraen-3 -yl] -2-(3-methylbutoxy)propanamide;

(2R)-2-(3-chlorophenoxy)-N-[l 0, 11 -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

(2S)-N-[9-acetyl-4-oxo-3-(trifluoromet^

tetraen-3-yl]-2-cyclohexylpropanamide;

(2S)-3-cyclopentyl-N-[10,l l-dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-2-hydroxypropanamide;

(2S)-2-(cyclopentylmethoxy)-N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3 -yl]propanamide;

3-cyclohexyl-N-[4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4 2'6]dodeca (12),6,8,10-tetraen-3 -yl]propanamide;

3-cyclopentyl-N-[ 10,1 1 -dimethyl-4-oxo-3-(trifluoromethyl)-2,5 ,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[ 10, 1 1 -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1 ( 12),6 ,8 , 10-tetraen-3 -yl] -6-[(2-methoxyethyl)amino]pyridine-2-carboxamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraen-3 -yl] -3 -( 1 -hydroxy eye lopentyl)propanamide;

3-cyclopentyl-N-[9-methanesulfonyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[9,10-difluoro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1( 12), 6,8,10-tetraen-3-yl]propanamide;

N-[9-acetyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[64 .02'66]dodeca-l (12),6,8,10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

3-(3,3-difluoroazetidin-l-yl)-N-[10,l l-dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

N-[9-cyano-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

3-cyclopentyl-N-[9-(2-methylpropanoyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1(12), 6, 8,10-tetraen-3 -yl] -3 -phenylpropanamide;

3,5-dichloro-N-[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1( 12), 6,8,10-tetraen-3-yl]benzamide;

3-cyclopentyl-N-[9-(4-methoxyphenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-(3-cyclopentylpropanamido)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraene-9-carboxylic acid;

3-cyclopentyl-N-{9-[4-(methylsulfanyl)phenyl]-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl}propanamide;

1 l-chloro-3-(3-cyclopentylpropanamido)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraene-9-carboxylic acid;

N-[9-(4-methoxyphenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraen-3 -yl]butanamide

2- [(2-methoxyethyl)amino]-N-[9-(4-methoxyphenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-l ,3-thiazole-4-carboxamide;

N-[9-bromo-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-2 -hydro xy-l ,3-thiazole-4-carboxamide;

N-[10,l 1 -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l (12),6,8,10-tetraen-3-yl]-2-[(2-methylpropyl)amino]-l ,3-thiazole-4-carboxamide;

3- cyclopentyl-N-{9-[4-(dimethylamino)phenyl]-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl}propanamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraen-3 -yl] -2 ,2 ,2-trifluoroacetamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraen-3 -yl] -2-(2-methoxyethoxy)pyridine-4-carboxamide;

3-cyclopentyl-N-[9-(4-methanesulfonylphenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraen-3 -yl] -2 ,2-dimethylpropanamide;

N-[9-acetyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]-2-(cyclopentylamino)-l ,3-thiazole-4-carboxamide;

N-[9-(3-chlorophenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-1(12), 6,8, 10-tetraen-3 -yl] -3 -cyclopentylpropanamide;

3-cyclopentyl-N-[4-oxo-3-(trifluoromethyl)-9-[4-(trifluoromethyl)phenyl]-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-cyclopentyl-N-[9-(4-fluorophenyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

3-(3-cyclopentylpropanamido)-N-methanesulfonyl-10-methoxy-4-oxo-3-(trifluoro methyl)- 2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraene-9-carboxamide;

3-cyclopentyl-N-[9-(methoxymethyl)-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-3-yl]propanamide;

tert-butyl 3- {[10,1 l-dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-1 ( 12), 6,8 , 10-tetraen-3 -yl] carbamoyl} pyrrolidine- 1 -carboxylate;

tert-butyl 4-{ [10,1 l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca- 1( 12), 6,8, 10-tetraen-3-yl]carbamoyl}piperi dine- 1 -carboxylate;

tert-butyl (2S)-2-{[10,l l-dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo- [6.4.0.02'6]dodeca-l(12),6, 8, 10-tetraen-3-yl]carbamoyl}pyrrolidine-l -carboxylate;

tert-butyl 3- {[10,1 l-dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca- 1( 12), 6,8, 10-tetraen-3-yl]carbamoyl}pyrrolidine-l -carboxylate;

tert-butyl 4- {[10,1 l-dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-1( 12), 6,8, 10-tetraen-3-yl]carbamoyl}piperi dine- 1 -carboxylate;

tert-butyl 3- {[10,1 l-dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca-1( 12), 6,8, 10-tetraen-3-yl]carbamoyl}azetidine-l -carboxylate;

tert-butyl 4-({[10,l l -dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo-[6.4.0.02'6]dodeca- 1 ( 12), 6,8 , 10-tetraen-3 -yl]carbamoyl} methyl)piperidine- 1 -carboxylate;

tert-butyl 2-(2- {[10,1 l-dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo- [6.4.0.02'6]dodeca-l(12),6, 8, 10-tetraen-3-yl] carbamoyl} ethyl)piperi dine- 1 -carboxylate;

tert-butyl 3- {[10,1 l-dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca- 1(8),6,9,1 l -tetraen-3-yl]carbamoyl}-3-fluoroazetidine-l -carboxylate;

methyl 3-[3-(3-cyclopentylpropanamido)-4-oxo-3-(trifluoromethyl)-2,5,7- triazatricyclo[6.4.0.02'6]dodeca-l(12),6,8,10-tetraen-9-yl]benzoate

N-[10,l l -dimethyl-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca- l(12),6,8,10-tetraen-3-yl]acetamide;

N-[9-bromo-10,l l -dimethyl-4-oxo-3-(trifiuoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca- 1(12), 6,8,10-tetraen-3 -yl] acetamide ; and

N-[10,l l -dimethyl-4-oxo-3-(trifiuoromethyl)-2,5,7-triazatricyclo[6.4.0.02'6]dodeca- 1 ( 12), 6,8 , 10-tetraen-3 -yl] -2-[(2-methoxyethyl)amino]pyrimidine-4-carboxamide;

or a pharmaceutically acceptable salt thereof.

12. The compound of any one of the claims 1 to 1 1 or a pharmaceutically acceptable salt thereof, for use in therapy.

13. A pharmaceutical composition comprising a compound according to any one of the claims 1 to 1 1 or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.

14. The compound of any one of the claims 1 to 1 lor a pharmaceutically acceptable salt thereof, for use in the treatment of cancer, an inflammatory disorder, an autoimmunity disorder or a neurodegenerative disorder.

15. A method of treatment of cancer, an inflammatory disorder, an autoimmunity disorder or a neurodegenerative disorder, by administering a compound according to any one of the claims 1 to 11 to a mammal in need of such treatment.