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1. (WO2015171872) SYSTÈMES ET PROCÉDÉS POUR DÉTECTER DE L'OXYDE NITRIQUE
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

CLAIMS

1. A diagnostic device for measuring a concentration of at least one of nitrite (N02~), nitrogen dioxide (N02), nitric oxide (NO), and other nitrogen oxides (NOx) on a substrate comprising:

a patch comprising at least one chemical compound capable of reacting with the at least one of nitrite, nitric oxide, nitrogen dioxide and other nitrogen oxides to provide an indicator.

2. The diagnostic device of claim 1, wherein the substrate is a skin surface.

3. The diagnostic device of claim 1, wherein the indicator is a color.

4. The diagnostic device of claim 3, wherein the intensity of the color correlates to the concentration of at least one of nitrite (N02~), nitrogen dioxide (N02), nitric oxide (NO), and other nitrogen oxides (NOx)

5. The diagnostic device of claim 1, further comprising a recording device.

6. The diagnostic device of claim 5, wherein the recording device is a camera, such as a digital camera.

7. The diagnostic device of claim 1, further comprising a component on a first surface of the patch for securing the device to the surface.

8. The diagnostic device of claim 7, wherein the component comprises an adhesive.

9. The diagnostic device of claim 7, further comprising a transparent layer on a second side of the patch.

10. The diagnostic device of claim 9, wherein the patch comprises at least one pad which comprises the chemical compound capable of reacting with the at least one of nitrite, nitrogen dioxide, nitric oxide, and other nitrogen oxides to provide an indicator.

11. The diagnostic device of claim 10, wherein the chemical compound is an aromatic primary amine.

12. The diagnostic device of claim 9, wherein the at least one of nitrite, nitrogen dioxide, nitric oxide, and other nitrogen oxides reacts with the aromatic primary amine to provide a diazonium ion.

13. The diagnostic device of claim 12, wherein the patch further comprises a membrane to provide a detection zone, the membrane comprising a nucleophilic aromatic amine detection reagent capable of reacting with the diazonium ion to form an azo indicator to exhibit a color that is different from a color of the nucleopilic aromatic amine detection reagent.

14. The diagnostic device of claim 10, further comprising at least one channel or barrier from the at least one pad to the substrate to provide selective control of the concentration of any of nitrite (N02~), nitrogen dioxide (N02), nitric oxide (NO), and other nitrogen oxides (NOx).

15. A method for measuring a concentration of at least one of nitrite (N02~), nitrogen dioxide (N02), nitric oxide (NO), and other nitrogen oxides (NOx) on a substrate comprising:

securing to the substrate a patch comprising at least one chemical compound capable of reacting with the at least one of nitrite, nitrogen dioxide, nitric oxide, and other nitrogen oxides to provide an indicator;

monitoring the indicator over a predetermined period of time to provide at least one measurement; and

comparing the at least one measurement to a known value to provide the concentration of the at least one of nitrite (N02~), nitrogen dioxide (N02), nitric oxide (NO), and other nitrogen oxides (ΝΟχ).

16. The method of claim 15, wherein securing comprises securing the substrate to a skin surface.

17. The method of claim 15, further comprising recording the indicator with a recording device.

18. The method of claim 17, wherein recording the indicator with a recording device comprises recording the indicator with a camera, such as a digital camera.

19. The method of claim 15, further comprising recording a time-course evolution of any of nitrite (N02~), nitrogen dioxide (N02), nitric oxide (NO), and other nitrogen oxides (NOx) by taking time-stamped photos.

20. The method of claim 15, wherein providing the indicator comprises providing a color indicator.

21. The method of claim 20, further comprising providing the indicator so that the intensity of the color correlates to the concentration of at least one of nitrite (N02~), nitrogen dioxide, (N02), nitric oxide (NO), and other nitrogen oxides (NOx)

22. The method of claim 15, further comprising providing the patch with a chemical compound capable of reacting with the at least one of nitrite, nitrogen dioxide, nitric oxide, and other nitrogen oxides to provide an indicator is an aromatic primary amine.

23. The method of claim 22, wherein the indicator is diazonium ion.

24. The method of claim 23, further comprising providing the patch with a membrane to provide a detection zone, the membrane comprising a nucleophilic aromatic amine detection reagent capable of reacting with the diazonium ion to form an azo indicator to exhibit a color that is different from a color of the nucleopilic aromatic amine detection reagent.

25. The method of claim 22, further comprising selectively retarding with a membrane the diffusion of at least one of nitrite, nitrogen dioxide, nitric oxide or nitrogen oxides so different cells exhibit differential color development.

26. The method of claim 23 where the membrane is a hydrophobic microporous membrane.