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1. WO2014100735 - DIAZOLE AMIDES

Numéro de publication WO/2014/100735
Date de publication 26.06.2014
N° de la demande internationale PCT/US2013/077257
Date du dépôt international 20.12.2013
CIB
C07D 249/06 2006.01
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
DCOMPOSÉS HÉTÉROCYCLIQUES
249Composés hétérocycliques contenant des cycles à cinq chaînons comportant trois atomes d'azote comme uniques hétéro-atomes du cycle
02non condensés avec d'autres cycles
04Triazoles-1, 2, 3; Triazoles-1, 2, 3 hydrogénés
06avec des radicaux aryle liés directement aux atomes du cycle
CPC
A61K 31/4155
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
4151,2-Diazoles
4155non condensed and containing further heterocyclic rings
A61K 31/4178
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41641,3-Diazoles
4178not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
A61K 31/4192
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41921,2,3-Triazoles
A61K 31/4196
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41961,2,4-Triazoles
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Déposants
  • CHEMOCENTRYX, INC. [US]/[US]
Inventeurs
  • CHEN, Xi
  • DRAGOLI, Dean R.
  • FAN, Pingchen
  • JAEN, Juan C.
  • LI, Yandong
  • POWERS, Jay P.
  • MALATHONG, Viengkham
  • PUNNA, Sreenivas
  • TANAKA, Hiroko
  • ZHANG, Penglie
Mandataires
  • KEZER, William B.
Données relatives à la priorité
61/745,44421.12.2012US
Langue de publication anglais (EN)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) DIAZOLE AMIDES
(FR) DIAZOLE AMIDES
Abrégé
(EN)
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
(FR)
L'invention concerne des composés qui agissent comme de puissants antagonistes du récepteur CCR1, et qui ont une activité anti-inflammatoire in vivo. Les composés sont des dérivés de diazole lactame et sont utiles dans des compositions pharmaceutiques, des procédés pour le traitement d'une maladie médiée par CCR1, et comme témoins dans des tests d'identification d'antagonistes compétitifs de CCR1.
Également publié en tant que
MXMX/a/2015/007853
Dernières données bibliographiques dont dispose le Bureau international