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1. (WO2012040223) PROCÉDÉ DE TRAITEMENT DE LA STÉATOSE HÉPATIQUE NON ALCOOLIQUE ET DU DIABÈTE DE TYPE II
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

1. A HepG2 cell line comprising an enhanced peroxisome targeting fluorescent reporter (EPTFR) that expresses a GFP variant labeling peroxisomes in live cells.

2. The cell line according to claim 1 wherein the EPTFR comprises a carboxy terminal three amino acid peptide Peroxisome Targeting Sequence 1 (PTS1).

3. The cell line according to claim 1 wherein the EPTFR comprises arginine- RSKL.

4. A method for identifying compounds that increase peroxisome biogenesis comprising adding a compound to the cell line of claim 1 and measuring peroxisome biogenesis.

5. An assay comprising the cell line of claim 1 and a means for measuring peroxisome biogenesis.

6. An assay comprising the cell line of claim 1 and a means for measuring cellular peroxisomal mass.