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1. WO2012007883 - COMPOSÉS CHIMIQUES

Numéro de publication WO/2012/007883
Date de publication 19.01.2012
N° de la demande internationale PCT/IB2011/053030
Date du dépôt international 07.07.2011
CIB
C07C 311/00 2006.01
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
CCOMPOSÉS ACYCLIQUES OU CARBOCYCLIQUES
311Amides d'acides sulfoniques, c. à d. composés comportant des atomes d'oxygène, liés par des liaisons simples, de groupes sulfoniques remplacés par des atomes d'azote, ne faisant pas partie de groupes nitro ou nitroso
A61P 29/00 2006.01
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
PACTIVITÉ THÉRAPEUTIQUE SPÉCIFIQUE DE COMPOSÉS CHIMIQUES OU DE PRÉPARATIONS MÉDICINALES
29Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p.ex. agents antirhumatismaux; Médicaments anti-inflammatoires non stéroïdiens (AINS)
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
C07C 2601/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
02with a three-membered ring
C07C 311/51
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
311Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
50Compounds containing any of the groups , X being a hetero atom, Y being any atom
51Y being a hydrogen or a carbon atom
C07D 231/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02not condensed with other rings
10having two or three double bonds between ring members or between ring members and non-ring members
12with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 233/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
56with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
60with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
C07D 237/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
237Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
02not condensed with other rings
06having three double bonds between ring members or between ring members and non-ring members
08with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Déposants
  • PFIZER LIMITED [GB/GB]; Ramsgate Road Sandwich Kent CT13 9NJ, GB (AllExceptUS)
  • BELL, Andrew, Simon [GB/GB]; GB (UsOnly)
  • BROWN, Alan, Daniel [GB/GB]; GB (UsOnly)
  • DE GROOT, Marcel, John [NL/GB]; GB (UsOnly)
  • LEWTHWAITE, Russell, Andrew [GB/GB]; GB (UsOnly)
  • MARSH, Ian, Roger [GB/GB]; GB (UsOnly)
  • MILLAN, David, Simon [AU/GB]; GB (UsOnly)
  • PEREZ PACHECO, Manuel [ES/GB]; GB (UsOnly)
  • RAWSON, David, James [GB/GB]; GB (UsOnly)
  • SCIAMMETTA, Nunzio [GB/GB]; GB (UsOnly)
  • STORER, Robert, Ian [GB/GB]; GB (UsOnly)
  • STUPPLE, Paul, Anthony [GB/GB]; GB (UsOnly)
  • SWAIN, Nigel, Alan [GB/GB]; GB (UsOnly)
Inventeurs
  • BELL, Andrew, Simon; GB
  • BROWN, Alan, Daniel; GB
  • DE GROOT, Marcel, John; GB
  • LEWTHWAITE, Russell, Andrew; GB
  • MARSH, Ian, Roger; GB
  • MILLAN, David, Simon; GB
  • PEREZ PACHECO, Manuel; GB
  • RAWSON, David, James; GB
  • SCIAMMETTA, Nunzio; GB
  • STORER, Robert, Ian; GB
  • STUPPLE, Paul, Anthony; GB
  • SWAIN, Nigel, Alan; GB
Données relatives à la priorité
61/363,35512.07.2010US
61/473,28708.04.2011US
61/488,97223.05.2011US
Langue de publication anglais (EN)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN
(FR) COMPOSÉS CHIMIQUES
Abrégé
(EN)
The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I):or a pharmaceutically acceptable salt thereof, wherein Ar1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
(FR)
Cette invention concerne des dérivés de sulfonamide, leur utilisation en médecine, des compositions les contenant, des procédés pour les préparer et les intermédiaires utilisés dans ces procédés. Plus particulièrement, cette invention concerne de nouveaux inhibiteurs de Nav1.7 de type sulfonamide de formule (I) : ou un sel pharmaceutiquement acceptable de ceux-ci; Ar1, X, R1, R2, R3, R4 et R5 dans la formule étant tels que définis dans la description. Les inhibiteurs de Nav 1.7 sont potentiellement utiles pour traiter toute une batterie d'affections, en particulier, la douleur.
Également publié en tant que
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