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1. WO2011115763 - INHIBITEURS DU COMPLEXE DU RÉCEPTEUR DU FACTEUR DE NÉCROSE TUMORALE

Numéro de publication WO/2011/115763
Date de publication 22.09.2011
N° de la demande internationale PCT/US2011/027371
Date du dépôt international 07.03.2011
CIB
A01N 31/14 2006.1
ANÉCESSITÉS COURANTES DE LA VIE
01AGRICULTURE; SYLVICULTURE; ÉLEVAGE; CHASSE; PIÉGEAGE; PÊCHE
NCONSERVATION DE CORPS HUMAINS OU ANIMAUX OU DE VÉGÉTAUX, OU DE PARTIES DE CEUX-CI; BIOCIDES, p.ex. EN TANT QUE DÉSINFECTANTS, PESTICIDES OU HERBICIDES; PRODUITS REPOUSSANT OU ATTIRANT LES ANIMAUX NUISIBLES; RÉGULATEURS DE CROISSANCE DES VÉGÉTAUX
31Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques de l'oxygène ou du soufre
08l'atome d'oxygène ou de soufre étant lié directement à un système cyclique aromatique
14Ethers
A61K 31/075 2006.1
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
31Préparations médicinales contenant des ingrédients actifs organiques 
075Ethers ou acétals
CPC
A61K 31/075
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
075Ethers or acetals
C07C 217/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
217Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
02having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
14the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
18the six-membered aromatic ring or condensed ring system containing that ring being further substituted
C07C 217/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
217Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
02having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
14the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
18the six-membered aromatic ring or condensed ring system containing that ring being further substituted
20by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
C07C 217/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
217Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
02having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
28having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
30having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
32the six-membered aromatic ring or condensed ring system containing that ring being further substituted
C07C 233/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
16having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
17with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
18having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
C07C 233/25
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
16having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
24with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
25having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
Déposants
  • THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US]/[US] (AllExceptUS)
  • MURALI, Ramachandran [US]/[US] (UsOnly)
  • GREENE, Mark, I. [US]/[US] (UsOnly)
Inventeurs
  • MURALI, Ramachandran
  • GREENE, Mark, I.
Mandataires
  • CALDWELL, John, W.
Données relatives à la priorité
61/313,87015.03.2010US
Langue de publication Anglais (en)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) INHIBITORS OF THE TUMOR NECROSIS FACTOR RECEPTOR COMPLEX
(FR) INHIBITEURS DU COMPLEXE DU RÉCEPTEUR DU FACTEUR DE NÉCROSE TUMORALE
Abrégé
(EN) The present invention relates to compounds of formula (I) that are inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-α mediated conditions: Formula (I)
(FR) La présente invention concerne des composés de formule (I) qui sont des inhibiteurs du récepteur I du facteur de nécrose tumorale, des compositions comprenant ces composés et des procédés d'utilisation de ces composés et leurs compositions dans le traitement de maladies dans lesquelles intervient le TNF-α : Formule (I)
Documents de brevet associés
Dernières données bibliographiques dont dispose le Bureau international