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1. (WO2008060784) SYSTÈME D'ANALYSE RAPIDE D'ESPÈCES PROTÉIQUES GLYQUÉES DANS DES ÉCHANTILLONS BIOLOGIQUES
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CLAIMS
We claim:
1. A system for quantitating a substance of interest in a sample, comprising:
(a) a chromatography module for analysis and/or purification of the
substance of interest;
(b) a detector module for sensing a quantifiable parameter of the substance of interest, and producing a signal representative of the quantifiable
parameter; and
(c) means for resolving the signal to quantify the quantifiable parameter as a quantification result, and for reporting the quantification result.
2. The system of claim 1, further comprising
means for quantitating plasma proteins that are separated from their
glycated analogs.
3. The system of claim 1, further comprising the sample, wherein the sample is a blood sample.
4. The system of claim 3, wherein the substance of interest is hemoglobin AIc.
5. The system of claim 1, wherein the chromatography module comprises a disposable chromatographic column.
6. A system for quantitating a substance of interest in a sample, comprising:
(a) a chromatography module for analysis and/or purification of the
substance of interest, wherein the chromatography module comprises a disposable chromatographic column that contains boronated packing
particles of from 20 to 200 microns in diameter, said column being
capable of separating the substance of interest at a flow rate from 5 to 100 micro liters per minute and an operation pressure of 200 psi or
less.
(b) a detector module for sensing a quantifiable parameter of the substance of interest, and producing a signal representative of the quantifiable
parameter; and
(c) means for resolving the signal to quantify the quantifiable parameter as a quantification result, and for reporting the quantification result.

7. A system for quantitating a substance of interest in a sample, comprising:
(a) a gripper module that translocates containers holding the sample to be measured;
(b) a mixing module for mixing the samples in respective containers;
(c) a chromatography module for purification of the substance of interest;

(d) a detector module for sensing a quantifiable parameter of the substance of interest, and producing a signal representative of the quantifiable
parameter; and
(e) means for resolving the signal to quantify the quantifiable parameter as a quantification result, and for reporting the quantification result.
8. The system of claim 7, further comprising a bar code reader to obtain the bar code information from the individual containers.
9. The system of claim 8, further comprising
a hemolysis module for lysing the red blood cells in the sample.
10. The system of claim 7, wherein the substance of interest is hemoglobin AIc.
11. The system of claim 7, wherein the a chromatography module comprises a disposable chromatographic column.
12. A system for measuring glycated hemoglobin AIc, comprising:
(a) a gripper module that translocates containers holding the sample to be
measured;
(b) a mixing module for mixing the sample in the container;
(c) a chromatography module for purification of the substance of interest, said chromatography module comprising a disposable chromatographic column; and
(d) a detector module for measuring the optical density of the substance of interest.
13. A disposable chromatographic column comprising
(a) a column body suitable for packing with materials ordinarily used in
the industry and which is used in the practice of liquid
chromatography, sample preparation, purification and the like;
(b) means for retaining the column packing materials by insertion of
retaining frits on either end of the column body;

(c) means for connecting the column body to a chromatography system by the use of simple Luer type fittings; and
(d) means for storing the columns through the use of Luer end caps to prevent the column packing materials from drying out.
14. A method for quantitating a substance of interest, comprising
adjusting the concentration of said substance to fall within a narrow, specified range of values; and
calculating the original concentration of the substance by retrograde
conversion.
15. The method of claim 14, wherein the substance of interest is hemoglobin AIc.
16. A method for analyzing a liquid sample each containing both glycated and non-glycated protein fractions, comprising the steps of:
(a) providing an affinity chromatographic column;
(b) contacting said column with said liquid sample containing said glycated
and non-glycated protein fractions,
(c) separating said non-glycated protein fraction from said glycated protein
fraction of the liquid sample with said column at an operation pressure of 200 psi or less.
17. The method of claim 16, wherein said column is a disposable chromatographic column.
18. The method of claim 16, further comprising the step of identifying each liquid sample through a bar code pre-affixed to the container holding said sample.