WIPO logo
Mobile | Deutsch | English | Español | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Recherche dans les collections de brevets nationales et internationales
World Intellectual Property Organization
Recherche
 
Options de navigation
 
Traduction
 
Options
 
Quoi de neuf
 
Connexion
 
Aide
 
Traduction automatique
1. (WO2008014240) INHIBITEURS DES IAP DIMÈRES
Dernières données bibliographiques dont dispose le Bureau international   

N° de publication :    WO/2008/014240    N° de la demande internationale :    PCT/US2007/074186
Date de publication : 31.01.2008 Date de dépôt international : 24.07.2007
CIB :
C07D 519/00 (2006.01), C07K 5/062 (2006.01), C07K 5/083 (2006.01), A61K 31/407 (2006.01), A61K 31/437 (2006.01), A61K 38/05 (2006.01), A61K 38/06 (2006.01)
Déposants : TETRALOGIC PHARMACEUTICALS CORPORATION [US/US]; 343 Phoenixville Pike, Malvern, Pennsylvania 19355 (US) (Tous Sauf US).
CONDON, Stephen, M. [US/US]; (US) (US Seulement)
Inventeurs : CONDON, Stephen, M.; (US)
Mandataire : SKERPON, Joseph, M.; Banner & Witcoff, Ltd., 1100 13th Street, N.W., Suite 1200, Washington, DC 20005-4051 (US)
Données relatives à la priorité :
60/820,172 24.07.2006 US
Titre (EN) DIMERIC IAP INHIBITORS
(FR) INHIBITEURS DES IAP DIMÈRES
Abrégé : front page image
(EN)Compounds made up of a homodimer or heterodimer having monomeric units of formula (I) : wherein: each A is, independently, NR1R2, or N+R1R2R3; each B is, independently, optionally substituted alkyl, alkenyl, or alkynyl, wherein one or more hydrogens are optionally replaced by fluorine; each U is, independently, CONH, C(O)O, C(S)O, C(S)NH, C(NH)NH, (CH2)1-5, or the inverse, thereof, wherein one or more carbons are optionally replaced by a heteroalom selected from O, S, and N; each V and W is, independently, (CH2)1-5, wherein one or more carbons are optionally replaced by C=O, C=S, or a heterσatom selected from O, S, and N, and one or more hydrogens are optionally replaced by a branched or unbraπched alkyl or cycloalkyl, an optionally substituted aryl, arylalkyl, heteroaryl, heteroarylalkyl, OR4, SR4, or NR4R5; each X is, independently, optionally substituted alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein one or more carbons are optionally replaced by C=O, C=S, or a heteroatom selected from O, S, and N, and one or more hydrogens are optionally replaced by a branched or unbranchcd alkyl or cycloalkyl, an optionally substituted aryl, arylalkyl, heteroaryl, heteroarylalkyl, OR4. SR4, or NR4R5; each Y is, independently, CH or N; each Z is, independently, CH2, C=O, C=S, CHSR, CHOR, or CHNR, compositions, and methods of using such compounds to modulate apoptosis including IAP antagonists are provided herein. Compositions including mimetics of the invention and, optionally, secondary agents, may be used to treat proliferative disorders such as, cancer and autoimmune diseases.
(FR)L'invention concerne des composés, des compositions et des procédés d'utilisation de tels composés pour moduler l'apoptose, ainsi que des antagonistes des IAP. Les compositions comprenant des mimétiques de l'invention et, éventuellement, des agents secondaires, peuvent s'utiliser pour traiter des troubles prolifératifs comme le cancer et des maladies auto-immunes.
États désignés : AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
Organisation régionale africaine de la propriété intellectuelle (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Office eurasien des brevets (OEAB) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
Office européen des brevets (OEB) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
Organisation africaine de la propriété intellectuelle (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Langue de publication : anglais (EN)
Langue de dépôt : anglais (EN)