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1. WO2007149310 - NANO-COMPOSANTS MULTIPHASIQUES BIOFONCTIONNELS ET PROCÉDÉS D'UTILISATION DESDITS NANO-COMPOSANTS

Numéro de publication WO/2007/149310
Date de publication 27.12.2007
N° de la demande internationale PCT/US2007/014028
Date du dépôt international 15.06.2007
CIB
A61K 9/14 2006.01
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
9Préparations médicinales caractérisées par un aspect particulier
14à l'état particulaire, p.ex. poudres
CPC
A61K 49/1854
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1818particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
1821coated or functionalised microparticles or nanoparticles
1824coated or functionalised nanoparticles
1827having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
1851having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
1854the organic macromolecular compound being obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly(meth)acrylate, polyacrylamide, polyvinylpyrrolidone, polyvinylalcohol
A61K 49/1887
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1818particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
1887Agglomerates, clusters, i.e. more than one (super)(para)magnetic microparticle or nanoparticle are aggregated or entrapped in the same maxtrix
A61K 9/1694
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1682Processes
1694resulting in granules or microspheres of the matrix type containing more than 5% of excipient
A61K 9/5089
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
5089Processes
A61K 9/5153
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
51Nanocapsules; Nanoparticles;
5107Excipients; Inactive ingredients
513Organic macromolecular compounds; Dendrimers
5146obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
5153Polyesters, e.g. poly(lactide-co-glycolide)
A61K 9/70
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
70Web, sheet or filament bases ; ; Films; Fibres of the matrix type containing drug;
Déposants
  • THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US/US]; Office of Technology Transfer 1214 S. University Avenue, 2nd Floor Ann Arbor, MI 48104-2594, US (AllExceptUS)
  • LAHANN, Joerg [DE/US]; US (UsOnly)
Inventeurs
  • LAHANN, Joerg; US
Mandataires
  • WOODSIDE-WOJTALA, Jennifer ; HARNESS, DICKEY & PIERCE PLC P. O. Box 828 Bloomfield Hills, MI 48303, US
Données relatives à la priorité
60/814,70616.06.2006US
Langue de publication anglais (EN)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) MULTIPHASIC BIOFUNCTIONAL NANO-COMPONENTS AND METHODS FOR USE THEREOF
(FR) NANO-COMPOSANTS MULTIPHASIQUES BIOFONCTIONNELS ET PROCÉDÉS D'UTILISATION DESDITS NANO-COMPOSANTS
Abrégé
(EN)
Multiphasic nano-components (MPNs) having at least two phases and at least one active ingredient are provided. The MPNs can be used in various methods for medical diagnostics or with pharmaceutical, personal care, oral care, and/or nutritional compositions, for example, in oral care, hair, or skin products. The MPNs can be designed to have targeted delivery within an organism, while providing controlled release systems or combining incompatible active ingredients. Further, the MPNs can be used as biomedical coatings (such as anti-microbial coatings), or anti-corrosive coatings, bioimaging probes with combined diagnostic and therapeutic use, and fragrance release systems, among others. The MPNs can be formed by electrified jetting of polymers.
(FR)
La présente invention concerne des nano-composants multiphasiques (MPN) présentant au moins deux phases et au moins un principe actif. Les MPN peuvent être utilisés dans divers procédés en vue de diagnostics thérapeutiques ou dans des compositions pharmaceutiques, de soins d'hygiène personnelle, de soins buccaux, et/ou d'ordre nutritionnel, notamment des produits de soins buccaux, capillaires ou pour la peau. Les MPN peuvent être conçus de façon à obtenir une libération ciblée dans un organisme, tout en produisant des systèmes de distribution régulée ou en combinant des principes actifs incompatibles. En outre, les MPN peuvent être utilisés sous la forme de revêtements biomédicaux (tels que des revêtements antimicrobiens), ou en tant que revêtements anticorrosifs, sondes de bio-imagerie combinées à un usage diagnostique et thérapeutique, et système de distribution de parfums, entre autres. Les MPN peuvent être formés par projection électrifiée de polymères.
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