Traitement en cours

Veuillez attendre...

Paramétrages

Paramétrages

1. WO2007144341 - DIFFÉRENTIATION DE CELLULES

Numéro de publication WO/2007/144341
Date de publication 21.12.2007
N° de la demande internationale PCT/EP2007/055754
Date du dépôt international 12.06.2007
CIB
C12N 5/071 2010.01
CCHIMIE; MÉTALLURGIE
12BIOCHIMIE; BIÈRE; SPIRITUEUX; VIN; VINAIGRE; MICROBIOLOGIE; ENZYMOLOGIE; TECHNIQUES DE MUTATION OU DE GÉNÉTIQUE
NMICRO-ORGANISMES OU ENZYMES; COMPOSITIONS LES CONTENANT; CULTURE OU CONSERVATION DE MICRO-ORGANISMES; TECHNIQUES DE MUTATION OU DE GÉNÉTIQUE; MILIEUX DE CULTURE
5Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
07Cellules animales ou tissus animaux
071Cellules ou tissus de vertébrés, p.ex. cellules humaines ou tissus humains
CPC
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
C12N 2500/25
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2500Specific components of cell culture medium
05Inorganic components
10Metals; Metal chelators
20Transition metals
24Iron; Fe chelators; Transferrin
25Insulin-transferrin; Insulin-transferrin-selenium
C12N 2501/119
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
10Growth factors
119Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
C12N 2501/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
10Growth factors
12Hepatocyte growth factor [HGF]
C12N 2501/39
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
30Hormones
38with nuclear receptors
39Steroid hormones
C12N 5/067
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
06Animal cells or tissues; Human cells or tissues
0602Vertebrate cells
067Hepatocytes
Déposants
  • VRIJE UNIVERSITEIT BRUSSEL [BE/BE]; Pleinlaan 2 B-1050 Brussel, BE (AllExceptUS)
  • ROGIERS, Vera [BE/BE]; BE (UsOnly)
  • VANHAECKE, Tamara [BE/BE]; BE (UsOnly)
  • SNYKERS, Sarah [BE/BE]; BE (UsOnly)
  • PAPELEU, Peggy [BE/BE]; BE (UsOnly)
  • VINKEN, Mathieu [BE/BE]; BE (UsOnly)
  • HENKENS, Tom [BE/BE]; BE (UsOnly)
  • DE ROP, Evelien [BE/BE]; BE (UsOnly)
  • FRACZEK, Joanna [PL/BE]; BE (UsOnly)
  • DE KOCK, Joery [BE/BE]; BE (UsOnly)
  • DOKTOROVA, Tatyana [BG/BE]; BE (UsOnly)
Inventeurs
  • ROGIERS, Vera; BE
  • VANHAECKE, Tamara; BE
  • SNYKERS, Sarah; BE
  • PAPELEU, Peggy; BE
  • VINKEN, Mathieu; BE
  • HENKENS, Tom; BE
  • DE ROP, Evelien; BE
  • FRACZEK, Joanna; BE
  • DE KOCK, Joery; BE
  • DOKTOROVA, Tatyana; BE
Mandataires
  • BRANTS, Johan Philippe Emile; De Clercq, Brants & Partners CV B-9830 Sint-Martens-Latem, BE
Données relatives à la priorité
PCT/EP2006/00562212.06.2006EP
Langue de publication anglais (EN)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) DIFFERENTIATION OF RAT LIVER EPITHELIAL CELLS INTO HEPATOCYTE-LIKE CELLS
(FR) DIFFÉRENTIATION DE CELLULES
Abrégé
(EN)
63 ABST RACT The present invention relates to methods for differentiation of cells of a rat liver epithelial (RLEC) cell line to hepatocyte-like cells, in particular involving sequential exposure of the said RLEC to two or more differentiation agents. The invention further relates to the so obtained cells and their uses in various pharmacological, toxicological, therapeutic, diagnostic and 5 research applications.
(FR)
La présente invention concerne des procédés permettant la différentiation de cellules issues d'une lignée cellulaire épithéliale hépatique de rat (CEHR) en cellules de type hépatocyte, impliquant en particulier une exposition séquentielle de ladite CEHR à deux ou plus de deux agents de différentiation. L'invention concerne en outre les cellules ainsi obtenues et leurs utilisations pour diverses applications pharmacologiques, toxicologiques, thérapeutiques, diagnostiques et de recherche.
Également publié en tant que
Dernières données bibliographiques dont dispose le Bureau international