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1. WO2007106951 - PROTÉINE ANTIMICROBIENNE

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WE CLAIM:
1. An antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof.

2. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to claim 1, wherein said peptide, derivative or analog has enhanced activity against one or a plurality of gram-negative bacteria relative to an equivalent amount of LL-37 peptide comprising amino acid residues 104-140 of the 18-kDa human cationic antimicrobial protein (hCAP18).

3. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to claim 1 or 2 having activity against one or more multidrug-resistant bacteria.

4. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to claim 1 or 2 having activity against a plurality of gram-negative bacteria.

5. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to claim 4 having activity against a bacterium belonging to a genus selected from the group consisting of Escherichia, Pseudomonas, Proteus, Salmonella, Acinetobacter and Klebsiella.

6. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to claim 1 or 2 having activity against a plurality of gram-positive bacteria.

7. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to claim 6 having activity against a bacterium belonging to a genus selected from the group consisting of Bacillus, Staphylococcus, Enterococcus and Streptococcus.

8. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to claim 1 or 2 having activity against one or more fungi of the genus Candida.

9. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to any one of claims 1 to 8 wherein the derivative is a fragment or processed form of the antimicrobial peptide fragment.

10. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to any one of claims 1 to 8 wherein the derivative is a fusion protein comprising the antimicrobial peptide fragment.

11. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to any one of claims 1 to 8 wherein the derivative comprises an amino acid sequence that is reversed relative to the sequence of the antimicrobial peptide fragment.

12. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to any one of claims 1 to 8 wherein the derivative is a peptide comprising one or more chemical moieties other than amino acids.

13. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to any one of claims 1 to 8 wherein the analog comprises one or more D-amino acids.

14. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to any one of claims 1 to 8 wherein said peptide fragment comprises at least six contiguous amino acid residues of an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 30 and SEQ ID NO: 31.

15. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to claim 14 wherein said peptide fragment comprises the amino acid sequence of SEQ ED NO: 1 or SEQ ID NO: 2.

16. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to claim 15 wherein said peptide fragment comprises the amino acid sequence of SEQ ID NO: 2.

17. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to claim 16 wherein said derivative or analog comprises a sequence selected from SEQ ID Nos: 3-17.

18. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to claim 14 wherein said peptide fragment comprises the amino acid sequence of SEQ ID NO: 18 or SEQ ID NO: 19.

19. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to claim 18 wherein said peptide fragment comprises the amino acid sequence of SEQ ID NO: 19.

20. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to claim 19 wherein said derivative or analog comprises a sequence selected from SEQ ID Nos: 20-29.

21. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to claim 14 wherein said peptide fragment comprises the amino acid sequence of SEQ ID NO: 30 or SEQ ID NO: 31.

22. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to claim 20 wherein said peptide fragment comprises the amino acid sequence of SEQ ID NO: 31.

23. The antimicrobial peptide fragment of a tammar wallaby milk protein or an antimicrobial derivative or analog thereof according to claim 21 wherein said derivative or analog comprises a sequence selected from SEQ ID Nos: 32-40.

24. A composition comprising an effective amount of an antimicrobial peptide, analog derivative, fusion protein or complex according to any one of claims 1 to 23 to treat a microbial infection in a mammalian host, wherein said peptide, analog or derivative is in combination with a pharmaceutically acceptable carrier or excipient or diluent.

25. A composition comprising an effective amount of an antimicrobial peptide, analog derivative, fusion protein or complex according to any one of claims 1 to 23 to induce, enhance or stimulate an immune response by a subject to an antigen wherein said peptide, analog or derivative is in combination with a pharmaceutically acceptable carrier or excipient or diluent.

26. A solid surface coated with or having adsorbed thereto an antimicrobial peptide, analog or derivative according to any one of claims 1 to 23.

27. A medical device coated with or having adsorbed thereto an antimicrobial peptide, analog or derivative thereof according to any one of claims 1 to 23.

28. A method of reducing or preventing microbial growth, said method comprising contacting a microorganism or a surface or composition of matter suspected of comprising a microorganism with a peptide, analog or derivative according to any one of claims 1 to 23 for a time and under conditions sufficient to reduce microbial growth and/or kill a microorganism, thereby reducing or preventing microbial growth.

29. Use of a peptide, analog and/or derivative according to any one of claims 1 to 23 in medicine.

30. Use of a peptide, analog and/or derivative according to any one of claims 1 to 23 in the preparation of a medicament for reducing or preventing microbial growth.

31. A method for prolonging the storage life of a perishable product, said method comprising:
(i) contacting a perishable product with an antimicrobial peptide or a derivative or analog thereof according to any one of claims 1 to 23 for a time and under conditions sufficient to reduce or prevent growth of a microorganism and/or to kill a microorganism; and
(ii) storing the perishable product.

32. The method of claim 32 wherein the perishable product comprises a food product, a pharmaceutical composition or a washing solution.

33. A method of therapeutic or prophylactic treatment of a subject comprising administering an antimicrobial peptide, analog or derivative according to any one of claims 1 to 23 to a subject in need thereof.

34. The method of claim 33 additionally comprising providing or obtaining an antimicrobial peptide, analog and/or derivative according to any one of claims 1 to 23.

35. The method of claim 34 comprising:
(i) determining a subject suffering from an infection or at risk of developing an infection;
(ii) obtaining the antimicrobial peptide, analog or derivative; and
(iii) administering said peptide, analog or derivative to said subject.

36. The method of claim 33 comprising:
(i) identifying a subject suffering from an infection or suspected of suffering from an infection or at risk of developing an infection; and
(ii) recommending administration of the antimicrobial peptide, analog or derivative thereof to the subject.