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1. (WO2007103221) PROCEDE AMELIORE POUR LA PREPARATION DE L'ARMODAFINIL
Dernières données bibliographiques dont dispose le Bureau international   

N° de publication :    WO/2007/103221    N° de la demande internationale :    PCT/US2007/005451
Date de publication : 13.09.2007 Date de dépôt international : 01.03.2007
CIB :
C07B 57/00 (2006.01), C07C 315/06 (2006.01), C07C 317/44 (2006.01), C07C 319/24 (2006.01), C07C 321/20 (2006.01), A61K 31/192 (2006.01), A61P 25/00 (2006.01)
Déposants : TEVA PHARMACEUTICAL INDUSTRIES LTD. [IL/IL]; 5 Basel Street, P.o. Box 3190, 49131 Petah Tiqva (IL) (AE, AG, AL, AM, AT, AU, AZ, BA, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SV, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
TEVA PHARMACEUTICALS USA, INC. [US/US]; 1090 Horsham Road, P.O. Box 1090, North Wales, PA 19454-1090 (US) (BB only).
MOSHKOVITS-KAPTSAN, Rinat [IL/IL]; (IL) (US Seulement).
BRAUDE, Viviana [IL/IL]; (IL) (US Seulement).
CHEN, Kobi [IL/IL]; (IL) (US Seulement).
ADLER, Miri [IL/IL]; (IL) (US Seulement)
Inventeurs : MOSHKOVITS-KAPTSAN, Rinat; (IL).
BRAUDE, Viviana; (IL).
CHEN, Kobi; (IL).
ADLER, Miri; (IL)
Mandataire : BIRDE, Patrick, J.; Kenyon & Kenyon Llp, One Broadway, New York, NY 10004-1050 (US)
Données relatives à la priorité :
60/778,334 01.03.2006 US
60/785,812 23.03.2006 US
60/878,097 28.12.2006 US
Titre (EN) AN IMPROVED PROCESS FOR THE PREPARATION OF ARMODAFINIL
(FR) PROCEDE AMELIORE POUR LA PREPARATION DE L'ARMODAFINIL
Abrégé : front page image
(EN)The invention encompasses processes for preparing intermediates, such as (R)-modafinic acid and its C1-2 alkyl ester, and the conversion of the intermediates into armodafinil. In particular, the invention concerns: (i) a process for the optical resolution of modafinic acid with (R)-α-naphthylethylamine and its conversion into armodafinil; (ii) (R)-modafinic acid containing less than 2% area by HPLC of (S)-modifinic acid; (iii) a process for the preparation of C1-2 alkyl ester of (R)-modafinic acid from (R)-modafinic acid by reaction with methanol or ethanol in the presence of at least one acidic reagent and its conversion into armodafinil; (iv) armodafinil with less than 0.5% area by HPLC of (S)-modafinil entantiomer, a pharmaceutical composition containing it and process for the preparation of this composition; (v) armodafinil with less than 0.1% area by HPLC of modafinic acid, a pharmaceutical composition containing it and process for the preparation of this composition; (vi) a process for the reduction of modafinic acid content in armodafjnil by contacting a solution with activated basic or neutral alumina; (vii) armodafinil with less than 0.2% area by HPLC of bis(diphenylmethyl) disulphide (R-MDF-DS), a pharmaceutical composition containing it and process for the preparation of this composition; (viii) a process for the preparation of R-MDF-DS from diphenylmethanethiol acetate; and (ix) a process for the reduction of R-MDF-DS content in armodafinil by suspending it in a C5-10 hydrocarbon.
(FR)La présente invention concerne des procédés pour la préparation d'intermédiaires, tels que l'acide R-modafinique ou le (R) ester alkylique en C1-2 de l'acide modafinique, ainsi que la conversion desdits intermédiaires en armodafinil.
États désignés : AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
Organisation régionale africaine de la propriété intellectuelle (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Office eurasien des brevets (OEAB) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
Office européen des brevets (OEB) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
Organisation africaine de la propriété intellectuelle (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Langue de publication : anglais (EN)
Langue de dépôt : anglais (EN)