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1. (WO2007008755) FONCTIONNALISATION DE SURFACE DE MATERIAUX POLYMERES
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

WE CLAIM:

1. A method of functionalizing a polymeric material, which comprises exposing a surface of a polymeric material to an atmospheric pressure glow plasma discharge under conditions wherein exposure to the plasma discharge functionalizes the surface of the polymeric material.

2. The method of claim 1, wherein the polymeric material is a biodegradable polymer.

3. The method of claim 2, wherein the biopolymer is poly (lactide-co-glycolide) (PGLA).

4. The method of claim 1, wherein the polymeric material is a particle or a scaffold.

5. The method of claim 1, which comprises:
entraining the polymeric material into a gas phase to form a suspended polymeric material; and
introducing the suspended polymeric material into a volume of the atmospheric pressure glow plasma discharge.

6. The method of claim 5, which further comprises collecting the suspended polymeric material from the atmospheric pressure glow plasma discharge.

7. The method of claim 6, which further comprises loading the surface of the ( functionalized polymeric material with a bioactive agent.

8. The method of claim 7, wherein the bioactive agent is a protein.

9. A composition comprising a polymeric material having a surface that has been exposed to an atmospheric pressure glow plasma discharge resulting in the presence of charges or charged radical groups on the surface of the polymeric material.

10. The composition of claim 9, which further comprises a bioactive agent associated with the charges or charged radical groups on the surface of the polymeric material.

11. The composition of claim 10, wherein the bioactive agent comprises a small molecule drug, a protein drug, a peptide drug, a DNA drug, a RNA drug, an oligonucleotide drug, an immunomodulatory agent, a vaccine antigen, or a contrast or imaging agent.

12. The composition of claim 10, wherein the bioactive agent is a protein.

13. The composition of claim 9, wherein the polymeric material is a biodegradable polymer.

14. A composition comprising a polymeric material having an interior and having a surface that has been exposed to an atmospheric pressure glow plasma discharge resulting in the presence of charges or charged radical groups on the surface of the polymeric material.

15. The composition of claim 14, which further comprises:
a first bioactive agent associated with the charges or charged radical groups on the surface of the polymeric material; and
a second bioactive substance disposed within the interior of the polymeric material.

16. The composition of claim 14, wherein the polymeric material is a biodegradable polymer.

17. The composition of claim 16, wherein the polymeric particle is a biodegradable particle of poly(lactide-co-glycolide).

18. The composition of claim 15, wherein the first bioactive agent and the second bioactive agent comprises a small molecule drug, a protein drug, a peptide drug, a DNA drug, a RNA drug, an oligonucleotide drug, an immunomodulatory agent, a vaccine antigen, or a contrast or imaging agent.

19. The composition of claim 15, wherein the first bioactive agent comprises a vaccine antigen; and the second bioactive agent comprises an immunomodulatory agent that regulates immune response to the vaccine antigen.

0. The composition of claim 15, wherein the polymeric material is a biopolymeric particle of poly(lactide-co-glycolide); the first bioactive agent comprises a vaccine, and the second bioactive agent comprises an immunomodulatory agent that regulates immune response to the vaccine.