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1. WO2006110448 - SYSTEMES POLYMERES THERMOGELIFIANTS BIOACTIFS ET LEURS PROCEDES D'UTILISATION

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]

1. A hydrogel comprising poly(N-alkylacrylamide), poly(alkyleneglycol)di-acrylate or methacrylate, cross-linking agent, a source of calcium ions, and water.

2. A hydrogel according to claim 1 wherein the poly(N-alkylacrylamide) is poly(N- isopropylacrylamide)

3. A hydrogel according to claim 1 wherein the poly(alkyleneglycol)di-acrylate or methacrylate is poly(ethyleneglycol)dimethacrylate or
poly(propyleneglycol)dimethacrylate.

4. A hydrogel according to claim 1 wherein the cross-linking agent is an acrylo-siloxane.

5. A hydrogel according to claim 1 wherein the cross-linking agent is an acryloxy- or methacryloxyalkylpolyalkoxysilane.

6. A hydrogel according to claim 1 wherein the cross-linking agent is 3- methacryloxypropyltrimethoxysilane.

7. A hydrogel according to claim 1 wherein the source of calcium ions is calcium chloride, calcium bromide, or calcium phosphate.

8. A hydrogel according to claim 1 wherein the source of calcium ions and cross-linking agent are present in a molar ratio of between about 1:1 to about 3:1.

9. A hydrogel according to claim 1 wherein the source of calcium ions and cross-linking agent are present in a molar ratio of about 2:1.

10. A hydrogel according to claim 1 further comprising at least one calcium-binding component.

11. A hydrogel according to claim 10 wherein the calcium-binding component is poly(acrylic acid), acrylic acid, poly(methacrylic acid), methacrylic acid, or mixtures thereof.

an amount of up to about 10% by weight.

13. A hydrogel according to claim 1 further comprising methyl methacrylate, poly(methyl
)
methacrylate), vinyl acetate, poly(vinyl acetate), or mixtures thereof.

14. A hydrogel according to claim 13 wherein the methyl methacrylate, poly(methyl methacrylate), vinyl acetate, poly(vinyl acetate), or mixtures thereof are present in an amount of up to about 25% by weight.

15. A hydrogel according to claim 1 further comprising a medicament, an osteoclastic inhibitor, a pain reliever, or a chemotherapeutic agent, or mixtures thereof.

16. A hydrogel according to claim 1 further comprising radiopacifiers, radiomarkers, or radiopaque material.

17. A hydrogel according to claim 1 further comprising about 65-85 weight percent of water.

18. A hydrogel according to claim 1 further comprising about 75 weight percent of water.

19. A hydrogel according to claim 1 having an equilibrium viscosity of about 75-125 Poise.

20. A hydrogel according to claim 1 having an equilibrium viscosity of about 115-125 Poise.

21. A hydrogel according to claim 1 having an equilibrium viscosity of about 118 Poise.

22. A hydrogel according to claim 1 having an equilibrium viscosity of about 75-90 Poise.

23. A hydrogel according to claim 1 having an equilibrium viscosity of about 83 Poise.

24. A hydrogel according to claim 1 having an elastic modulus of about 0.5-0.9 MPa.

25. A hydrogel according to claim 1 having an elastic modulus of about 0.7 MPa.

26. A hydrogel according to claim 1, said hydrogel being prepared using N-alkylacrylamide.

isopropylacrylamide.

28. A hydrogel according to claim 26 wherein the N-alkylacrylamide and
poly(alkyleneglycol)di-acrylate or methacrylate are present in a ratio of from about 250:1 to about 150:1 by weight.

29. A hydrogel according to claim 26 wherein the N-alkylacrylamide and
poly(alkyleneglycol)di-acrylate or methacrylate are present in a ratio of about 200: 1 by weight.

30. A hydrogel according to claim 26 wherein the cross-linking agent and N-alkylacrylamide are present in a molar ratio of up to about 0.01.

31. A hydrogel according to claim 26 wherein the molar ratio of cross-linking agent:N- alkylacrylamide is between about 0.0005 and 0.01.

32. A hydrogel according to claim 26 wherein the molar ratio of cross-linking agent:N- alkylacrylamide is about 0.0005.

33. A hydrogel according to claim 26 wherein the molar ratio of cross-linking agent:N- alkylacrylamide is about 0.0075.

34. A hydrogel according to claim 26 wherein the molar ratio of cross-linking agentN- alkylacrylamide is about 0.005.

35. A hydrogel according to claim 26 wherein the molar ratio of cross-linking agent:N- alkylacrylamide is about 0.003.

36. A hydrogel according to claim 26 wherein the molar ratio of cross-linking agent:N- alkylacrylamide is about 0.001.

37. A hydrogel according to claim 26 wherein the molar ratio of cross-linking agent:N- alkylacrylamide is about 0.01.

fracture a hydro gel according to claim 1.

39. A method of reinforcing a vertebral bone structure comprising injecting into the vicinity of the bone structure a hydrogel according to claim 1.

40. A method of resurfacing an articulating joint comprising providing to the joint a hydrogel according to claim 1.

41. A method of preparing a hydrogel comprising:
(a) providing a mixture of N-alkylacrylamide and poly(alkyleneglycol)di-acrylate or methacrylate in a solvent to form a first mixture;
(b) adding a cross-linking agent, a source of calcium ions, and an initiator to the first mixture to form a second mixture;
(c) polymerizing the second mixture for a time and at a temperature sufficient to
cause polymerization to form a polymer;
(d) drying the polymer;
(e) pulverizing the polymer to form a powder; and
(T) adding water to the powder

42. The method of claim 41 wherein the N-alkylacrylamide and poly(alkyleneglycol)di- acrylate or methacrylate are present in a ratio of from about 250:1 to about 150:1 by weight.

43. The method of claim 41 wherein the N-alkylacrylamide and poly(alkyleneglycol)di- acrylate or methacrylate are present in a ratio of about 200:1 by weight.

44. The method of claim 41 wherein the N-alkylacrylamide is N-isopropylacrylamide.

45. The method of claim 41 wherein the poly(alkyleneglycol)di-acrylate or methacrylate is poly(ethyleneglycol)dimethacrylate or poly(propyleneglycol)dimethacrylate.

46. The method of claim 41 wherein the source of calcium ions is calcium chloride, calcium bromide, or calcium phosphate.

present in a molar ratio of about 2: 1.

48. The method of claim 41 wherein the cross-linking agent is an acrylo-siloxane.

49. The method of claim 41 wherein the cross-linking agent is an acryloxy- or
methacryloxyalkylpolyalkoxysilane.

50. The method of claim 41 wherein the cross-linking agent is 3- methacryloxypropyltrimethoxysilane.

51. A method of repairing a vertebral fracture comprising injecting into the vicinity of the fracture a hydrogel comprising poly(N-alkylacrylamide), poly(alkyleneglycol)di-acrylate or methacrylate, cross-linking agent, a source of calcium ions, and water.

52. The method of claim 51 wherein the poly(N-alkylacrylamide) is poly(N- isopropylacrylamide).

53. The method of claim 51 wherein the poly(alkyleneglycol)di-acrylate or methacrylate is poly(ethyleneglycol)dimethacrylate.

54. The method of claim 51 wherein the poly(alkyleneglycol)di-acrylate or methacrylate is poly(propyleneglycol)dimethacrylate.

55. The method of claim 51 wherein the source of calcium ions is calcium chloride, calcium bromide, or calcium phosphate.

56. The method of claim 51 wherein the source of calcium ions and cross-linking agent are present in a molar ratio of about 2:1.

57. The method of claim 51 wherein the cross-linking agent is an acrylo-siloxane.

58. The method of claim 51 wherein the cross-linking agent is an acryloxy- or
methacryloxyalkylpolyalkoxysilane.

methacryloxypropyltrimethoxysilane.

60. The method of claim 51, said hydrogel being prepared using N-alkylacrylamide.

61. The method of claim 60 wherein the N-alkylacrylamide is N-isopropylacrylamide.

62. The method of claim 60 wherein the N-alkylacrylamide and poly(alkyleneglycol)di- acrylate or methacrylate are present in a ratio of from about 250:1 to about 150:1 by weight.

63. The method of claim 60 wherein the N-alkylacrylamide and poly(alkyleneglycol)di- acrylate or methacrylate are present in a ratio of about 200: 1 by weight.

64. The method of claim 60 wherein the cross-linking agent and N-alkylacrylamide are present in a molar ratio of up to about 0.01.

65. A method of reinforcing a vertebral bone structure comprising injecting into the vicinity of the bone structure a hydrogel comprising poly(N-alkylacrylamide),
poly(alkyleneglycol)di-acrylate or methacrylate, cross-linking agent, a source of calcium ions, and water.

66. The method of claim 65 wherein the poly(N-alkylacrylamide) is poly(N- isopropylacrylamide).

67. The method of claim 65 wherein the poly(alkyleneglycol)di-acrylate or methacrylate is poly(ethyleneglycol)dimethacrylate.

68. The method of claim 65 wherein the poly(alkyleneglycol)di-acrylate or methacrylate is poly(propyleneglycol)dimethacrylate.

69. The method of claim 65 wherein the source of calcium ions is calcium chloride, calcium bromide, or calcium phosphate.

70. The method of claim 65 wherein the source of calcium ions and cross-linking agent are present in a molar ratio of about 2: 1.

72. The method of claim 65 wherein the cross-linking agent is an acryloxy- or
methacryloxyalkylpolyalkoxysilane.

73. The method of claim 65 wherein the cross-linking agent is 3- methacryloxypropyltrimethoxysilane.

74. The method of claim 65, said hydrogel being prepared using N-alkylacrylamide.

75. The method of claim 74 wherein the N-alkylacrylamide is N-isopropylacrylamide.

76. The method of claim 74 wherein the N-alkylacrylamide and poly(alkyleneglycol)di- acrylate or methacrylate are present in a ratio of from about 250:1 to about 150:1 by weight.

77. The method of claim 74 wherein the N-alkylacrylamide and poly(alkyleneglycol)di- acrylate or methacrylate are present in a ratio of about 200:1 by weight.

78. The method of claim 74 wherein the cross-linking agent and N-alkylacrylamide are present in a molar ratio of up to about 0.01.

79. A method of resurfacing an articulating joint comprising providing to the joint a hydrogel comprising poly(N-alkylacrylamide), poly(alkyleneglycol)di-acrylate or methacrylate, cross-linking agent, a source of calcium ions, and water.

80. The method of claim 79 wherein the poly(N-alkylacrylamide) is poly(N- isopropylacrylamide).

81. The method of claim 79 wherein the poly(alkyleneglycol)di-acrylate or methacrylate is poly(ethyleneglycol)dimethacrylate.

82. The method of claim 79 wherein the poly(alkyleneglycol)di-acrylate or methacrylate is poly(propyleneglycol)dimethacrylate.

bromide, or calcium phosphate.

84. The method of claim 79 wherein the source of calcium ions and cross-linking agent are present in a molar ratio of about 2:1.

85. The method of claim 79 wherein the cross-linking agent is an acrylo-siloxane.

86. The method of claim 79 wherein the cross-linking agent is an acryloxy- or
methacryloxyalkylpolyalkoxysilane.

87. The method of claim 79 wherein the cross-linking agent is 3- methacryloxypropyltrimethoxysilane.

88. The method of claim 79, said hydrogel being prepared using N-alkylacrylamide.

89. The method of claim 88 wherein the N-alkylacrylamide is N-isopropylacrylamide.

90. The method of claim 88 wherein the N-alkylacrylamide and poly(alkyleneglycol)di- acrylate or methacrylate are present in a ratio of from about 250: 1 to about 150: 1 by weight.

91. The method of claim 88 wherein the N-alkylacrylamide and poly(alkyleneglycol)di- acrylate or methacrylate are present in a ratio of about 200:1 by weight.

92. The method of claim 88 wherein the cross-linking agent and N-alkylacrylamide are present in a molar ratio of up to about 0.01.