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1. WO2006006021 - COMPOSITIONS PHARMACEUTIQUES STABILISEES

Numéro de publication WO/2006/006021
Date de publication 19.01.2006
N° de la demande internationale PCT/IB2005/001836
Date du dépôt international 28.06.2005
CIB
A61K 9/20 2006.01
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
9Préparations médicinales caractérisées par un aspect particulier
20Pilules, pastilles ou comprimés
CPC
A61K 9/2009
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2009Inorganic compounds
A61K 9/2013
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2013Organic compounds, e.g. phospholipids, fats
A61K 9/2018
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2013Organic compounds, e.g. phospholipids, fats
2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
A61K 9/2027
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2022Organic macromolecular compounds
2027obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
A61K 9/2054
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2022Organic macromolecular compounds
205Polysaccharides, e.g. alginate, gums; Cyclodextrin
2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
F16H 59/10
FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
HGEARING
59Control inputs to ; control units of; change-speed-, or reversing-gearings for conveying rotary motion
02Selector apparatus
08Range selector apparatus
10comprising levers
Déposants
  • GLENMARK PHARMACEUTICALS LIMITED [IN]/[IN] (AllExceptUS)
  • SRINIVAS, Arra, Ganga [IN]/[IN] (UsOnly)
  • SAPRE, Beena, Amol [IN]/[IN] (UsOnly)
  • CHACHARE, Yogesh, Ananda [IN]/[IN] (UsOnly)
  • KRISHNAN, Anandi [IN]/[IN] (UsOnly)
Inventeurs
  • SRINIVAS, Arra, Ganga
  • SAPRE, Beena, Amol
  • CHACHARE, Yogesh, Ananda
  • KRISHNAN, Anandi
Données relatives à la priorité
60/583,55028.06.2004US
Langue de publication anglais (EN)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) STABILIZED PHARMACEUTICAL COMPOSITIONS OF PREFERABLY A STATIN
(FR) COMPOSITIONS PHARMACEUTIQUES STABILISEES
Abrégé
(EN)
Stabilized pharmaceutical composition comprising a therapeutically effective amount of one or more active pharmaceutical ingredients capable of degradation in a low pH environment and a stabilizing effective amount of one or more amino-group containing monomeric compounds and/or amido-group containing monomeric compounds for the stabilization of the active pharmaceutical ingredientare provided. The present invention also provides for the use of such stabilized pharmaceutical compositions for the treatment of dyslipidemias including, for example, hyperlipidemia, hypercholesterolemia and hypertriglyceridemia. Preferred active pharmaceutical ingredients are a statin such as pravastatin or atorvastatin. Preferred stabilizing compounds are meglumine, triethanolamine, tromethamine or sodium chloride. The composition is preferably in form of a tablet or granules.
(FR)
Composition pharmaceutique stabilisée contenant une quantité efficace sur le plan thérapeutique d'un ou plusieurs ingrédients pharmaceutiques actifs capables de se dégrader dans un milieu à pH bas, et une quantité stabilisante d'un ou de plusieurs composés monomères contenant des groupes aminés et/ou de composés monomères contenant des groupes aminés servant à stabiliser les ingrédients actifs sur le plan pharmaceutique. L'invention concerne également l'utilisation de ces compositions pharmaceutiques stabilisées pour traiter des dyslipidémies, y compris, par exemple, l'hyperlipidémie, l'hypercholestérolémie et l'hypertriglycéridémie.
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