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1. WO2005007687 - COMPOSITIONS ET PROCEDES DE MODULATION DU DECLENCHEMENT FOLLICULAIRE OVARIEN

Numéro de publication WO/2005/007687
Date de publication 27.01.2005
N° de la demande internationale PCT/US2004/021814
Date du dépôt international 07.07.2004
CIB
C07K 14/00 2006.01
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
KPEPTIDES
14Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
CPC
A01K 2217/075
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
07Animals genetically altered by homologous recombination
075inducing loss of function, i.e. knock out
A01K 2227/105
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
105Murine
A01K 2267/03
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
03Animal model, e.g. for test or diseases
A01K 67/0276
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
0275Genetically modified vertebrates, e.g. transgenic
0276Knockout animals
C07K 14/4705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4702Regulators; Modulating activity
4705stimulating, promoting or activating activity
C12N 15/8509
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
8509for producing genetically modified animals, e.g. transgenic
Déposants
  • DANA-FARBER CANCER INSTITUTE, INC [US/US]; 44 Binney Street Boston, MA 02115, US (AllExceptUS)
  • CASTRILLON, Diego, H. [US/US]; US (UsOnly)
  • DEPINHO, Ronald, A. [US/US]; US (UsOnly)
Inventeurs
  • CASTRILLON, Diego, H.; US
  • DEPINHO, Ronald, A.; US
Mandataires
  • SMITH, DeAnn, F. ; Foley Hoag LLP Seaport World Trade Center West 155 Seaport Boulevard Boston, MA 02210-2698, US
Données relatives à la priorité
60/486,01609.07.2003US
Langue de publication anglais (EN)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) COMPOSITIONS AND METHODS FOR MODULATING OVARIAN FOLLICULAR INITIATION
(FR) COMPOSITIONS ET PROCEDES DE MODULATION DU DECLENCHEMENT FOLLICULAIRE OVARIEN
Abrégé
(EN)
The present invention provides methods for modulating ovarian follicular initiation, modulating fertility, treating infertility, and treating hormone-related diseases or disorders comprising modulating the expression or activity of FOXO3a. The present invention also provides an animal, e.g., transgenic mouse, in which the FOXO3a gene is misexpressed. Methods for identifying contraceptive agents are also described. Also described are methods for diagnosing premature ovarian failure (POF).
(FR)
La présente invention concerne des procédés de modulation du déclenchement folliculaire ovarien, de modulation de la fertilité, de traitement de l'infertilité et de traitement de maladie ou de troubles d'origine hormonale consistant à moduler l'expression ou l'activité de FOXO3a. La présente invention met en lumière un animal, par exemple une souris transgénique, dans lequel le gène FOXO3a présente une anomalie d'expression. Sont également présentés les procédés d'identification d'agents contraceptifs ainsi que des procédés de diagnostic d'une insuffisance ovarienne primitive (IOP).
Dernières données bibliographiques dont dispose le Bureau international