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1. WO2005004809 - PORTEUSES POLYVALENTES D'ANTICORPS BISPECIFIQUES

Numéro de publication WO/2005/004809
Date de publication 20.01.2005
N° de la demande internationale PCT/US2004/020995
Date du dépôt international 01.07.2004
CIB
C07K 16/00 2006.01
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
KPEPTIDES
16Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux
A61K 39/395 2006.01
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
39Préparations médicinales contenant des antigènes ou des anticorps
395Anticorps; Immunoglobulines; Immunsérum, p.ex. sérum antilymphocitaire
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 47/6897
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6891Pre-targeting systems involving an antibody for targeting specific cells
6897Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
A61K 51/1027
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
08Peptides, e.g. proteins ; , carriers being peptides, polyamino acids, proteins
10Antibodies or immunoglobulins; Fragments thereof ; , the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody
1003not used, see subgroups
1027against receptors, cell-surface antigens, cell-surface determinants
A61K 51/1048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
08Peptides, e.g. proteins ; , carriers being peptides, polyamino acids, proteins
10Antibodies or immunoglobulins; Fragments thereof ; , the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody
1003not used, see subgroups
1045against animal or human tumor cells or tumor cell determinants
1048the tumor cell determinant being a carcino embryonic antigen
A61K 51/109
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
08Peptides, e.g. proteins ; , carriers being peptides, polyamino acids, proteins
10Antibodies or immunoglobulins; Fragments thereof ; , the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody
1003not used, see subgroups
1084the antibody being a hybrid immunoglobulin
109immunoglobulins having two or more different antigen-binding sites, multifunctional antibodies
B82Y 5/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Déposants
  • IMMUNOMEDICS, INC. [US/US]; 300 American Road Morris Plains, NJ 07950, US (AllExceptUS)
  • HANSEN, Hans, J. [US/US]; US (UsOnly)
  • MCBRIDE, William, J. [US/US]; US (UsOnly)
  • QU, Zhengxing [US/US]; US (UsOnly)
Inventeurs
  • HANSEN, Hans, J.; US
  • MCBRIDE, William, J.; US
  • QU, Zhengxing; US
Mandataires
  • BOOTH, Paul, M. ; Heller Ehrman White & McAuliffe LLP Suite 300 1666 K Street, NW Washington, DC 20006-1228, US
Données relatives à la priorité
60/483,83201.07.2003US
Langue de publication anglais (EN)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) MULTIVALENT CARRIERS OF BI-SPECIFIC ANTIBODIES
(FR) PORTEUSES POLYVALENTES D'ANTICORPS BISPECIFIQUES
Abrégé
(EN)
Provided herein are targetable constructs that are multivalent carriers of bi-specific antibodies, i.e., each molecule of a targetable construct can serve as a carrier of two or more bi-specific antibodies. Also provided are targetable complexes formed by the association of a targetable construct with two or more bi-specific antibodies. The targetable constructs and targetable complexes of the invention are incorporated into biosensors, kits and pharmaceutical compositions, and are used in a variety of therapeutic and other methods.
(FR)
L'invention concerne des constructions pouvant être ciblées qui sont des porteuses polyvalentes d'anticorps bispécifiques, c'est-à-dire, que chaque molécule d'une construction pouvant être ciblée peut servir en tant que porteuse d'au moins deux anticorps bispécifiques. L'invention concerne également des complexes pouvant être ciblés formés par l'association d'une construction pouvant être ciblée avec au moins deux anticorps bispécifiques. Les constructions pouvant être ciblées et les complexes pouvant être ciblés de l'invention sont incorporés dans des biodétecteurs, des kits et des compositions pharmaceutiques, et ils sont utilisés dans une pluralité de procédés thérapeutiques et d'autres procédés.
Dernières données bibliographiques dont dispose le Bureau international