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1. WO2004100817 - COMPRIME POUR LA CAVITE BUCCALE

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]

CLAIMS

1. A water soluble, non-abrasive, effervescent, chewable tablet for use in the oral cavity, comprising:
a pharmaceutically acceptable water soluble carbon dioxide source, a pharmaceutically acceptable water soluble acid source and a water soluble tablet forming material admixed to form a chewable tablet having less than 0.2% water, the percent by weight of tablet forming material ranges from about 10% to about 70% of the total tablet weight, and the pH of the tablet when dissolved in water to form a 1.0% by weight aqueous solution ranges from about 5.0 to about 7.0; and
a flavor imparting flavor agent in an amount ranging from about 0.001% to 5.0 %, said flavor agent amount being sufficient to mask taste sensations derived from said carbon dioxide source, acid source and binder to provide an abrasive free texture to the tongue in said oral cavity.

2. The tablet of claim 1, wherein said carbon dioxide source is selected from the group consisting of sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate, calcium carbonate, magnesium carbonate and mixtures thereof.

3. The tablet of claim 2, wherein said acid source is selected from citric acid, fumaric acid, tartaric acid, malic acid, adipic acid and mixtures thereof, and wherein the carbonate to acid ratio ranges from about 2.33 : 1 to about 3.33: 1.

4. The tablet of claim 1, wherein said tablet forming material is selected from the group consisting of (1) lubricants selected from the group consisting of polyethylene glycol, polypropylene glycol, polyvinyl alcohol, polyvinyl pyrrolidone, sucrose stearate, sodium benzoate, leucine, magnesium stearate, sodium lauryl sulfate, sodium lauryl sulfoacetate, and mixtures thereof, (2) binders selected from the group consisting of sorbitol, lactose, urea, starch, maltodextrin, corn syrup solids, sodium citrate, sodium sulfate, sodium chloride, sucrose, dextrates, and mixtures thereof, and (3) mixtures thereof.

5. The tablet of claim 1, wherein said flavor imparting flavor agent is selected from the group consisting of citrus types, ginger, berries, and mint types.

6. The tablet of claim 1, which further includes an anhydrous surfactant in an amount sufficient to generate foam functioning as a dentifrice.

7. The tablet of claim 1, which further includes at least one a treating agent selected from the group consisting of anticaries ingredients, bleaching agents, enzymes to remove plaque and clean the teeth, desensitizing agents, antimicrobial agents, breath freshening ingredients, prescription medicines and dyes used at levels that will color the chewed tablet.

8. The tablet of claim 6, wherein said anhydrous surfactant is selected from the group consisting of sodium lauryl sulfate, sodium lauryl sulfoacetate, cocamidopropyl betaine, sodium alpha olefin sulfonate, dioctyl sodium sulfosuccinate, and sodium dodecyl benzene sulfonate and mixtures thereof.

9. The tablet of claim 7, wherein said anticaries ingredient is selected from the group consisting of sodium fluoride, sodium monofluorophosphate, starmous fluoride and mixtures thereof.

10. The tablet of claim 7, wherein said bleaching agent is selected from the group consisting of such as carbamide peroxide (also known as urea peroxide), sodium perborate, sodium percarbonate and mixtures thereof.

11. The tablet of claim 7, wherein said enzyme to remove plaque and clean the teeth is selected from the group consisting of proteases, amylases, lipases and mixtures thereof.

12. The tablet of claim 7, wherein said desensitizing agents is selected from the group consisting of strontium nitrate, potassium nitrate and mixtures there of.

13. The tablet of claim 7, wherein said antimicrobial agent is selected from the group consisting of cetylpyridinium chloride, domiphen bromide and mixtures thereof.

14. The tablet of claim 7, wherein said breath freshening ingredients is selected from the group consisting of citrus types, ginger, berries, mint types, chlorophyll and mixtures thereof.

15. The tablet of claim 7, wherein said other prescription medicines is selected from the group consisting of antibiotics, chlorhexidine gluconate and mixtures thereof.

16. The tablet of claim 7, wherein said dye is selected from the group consisting of cetylpyridinium chloride, domiphen bromide and mixtures thereof.

17. A water soluble, non-abrasive, effervescent, oral care tablet for use in the oral cavity, comprising:
a pharmaceutically acceptable water soluble carbon dioxide source selected from the group consisting of sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate, calcium carbonate, magnesium carbonate and mixtures thereof, a pharmaceutically acceptable water soluble acid source selected from citric acid, fumaric acid, tartaric acid, malic acid, adipic acid and mixtures thereof, and a water soluble tablet forming material selected from the group consisting of (1) lubricants selected from the group consisting of polyethylene glycol, sucrose stearate, polypropylene glycol, polyvinyl alcohol, polyvinyl pyrrolidone, sodium benzoate, leucine, magnesium stearate, sodium lauryl sulfate, sodium lauryl sulfoacetate, and mixtures thereof, (2) binders selected from the group consisting of sorbitol, lactose, urea, starch, maltodextrin, corn syrup solids, sodium citrate, sodium sulfate, sodium chloride, sucrose, dextrates, and mixtures thereof, and (3) mixtures thereof; admixed to form a chewable tablet having less than 0.2% water, the percent by weight of binder ranges from about 10% to about 70% of the total tablet weight, and the pH of the tablet when dissolved in water to form a 1.0% by weight aqueous solution ranges from about 5.0 to about 7.0; and
a flavor imparting flavor agent selected from the group consisting of citrus types, ginger, berries, and mint types in an amount ranging from about 0.001% to 5.0 %, said flavor agent amount being sufficient to mask taste sensations derived from said carbon dioxide source, acid source and binder to provide an abrasive free texture to the tongue in said oral cavity.

18. The tablet of claim 17, which further includes at least one a treating agent selected from the group consisting of an anhydrous surfactant in an amount sufficient to generate foam functioning as a dentifrice, anticaries ingredients, bleaching agents, enzymes to remove plaque and clean the teeth, desensitizing agents, antimicrobial agents, breath freshening ingredients, prescription medicines and dyes used at levels that will color the chewed tablet.

19. The tablet of claim 17, wherein said anhydrous surfactant is selected from the group consisting of sodium lauryl sulfate, sodium lauryl sulfoacetate, cocamidopropyl betaine, sodium alpha olefin sulfonate, dioctyl sodium sulfosuccinate, and sodium dodecyl benzene sulfonate and mixtures thereof.

20. The tablet of claim 17, wherein said anticaries ingredient is selected from the group consisting of sodium fluoride, sodium monofluorophosphate, stannous fluoride and mixtures thereof.

21. The tablet of claim 17, wherein said bleaching agent is selected from the group consisting of such as carbamide peroxide (also known as urea peroxide), sodium perborate, sodium percarbonate and mixtures thereof.

22. The tablet of claim 17, wherein said enzyme to remove plaque and clean the teeth is selected from the group consisting of proteases, amylases, lipases and mixtures thereof.

23. The tablet of claim 17, wherein said desensitizing agents is selected from the group consisting of strontium nitrate, potassium nitrate and mixtures there of.

24. The tablet of claim 17, wherein said antimicrobial agent is selected from the group consisting of cetylpyridinium chloride, domiphen bromide and mixtures thereof.

25. The tablet of claim 17, wherein said breath freshening ingredients is selected from the group consisting of citrus types, ginger, berries, mint types, chlorophyll and mixtures thereof.

26. The tablet of claim 17, wherein said other prescription medicines is selected from the group consisting of antibiotics, chlorhexidine gluconate and mixtures thereof.

27. The tablet of claim 17, wherein said dye is selected from the group consisting of cetylpyridinium chloride, domiphen bromide and mixtures thereof, wherein the carbonate to acid ratio ranges from about 2.33 : 1 to about 3.33: 1,

28. The tablet of claim 17, wherein the carbonate to acid ratio ranges from about 2.33:1 to about 3.33:1,