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4. (WO2003011200) DISPOSITIF INTRA-UTERIN, PROCEDE DE FABRICATION D'UN TEL DISPOSITIF ET PROCEDE DE POSE D'ELEMENTS ACTIFS A L'INTERIEUR DE LA CAVITE UTERINE
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CLAIMS

1. A retrievable intrauterine device for placing within the uterine cavity one or more encapsulated elements capable of having interactions with the uterine fluid comprising an intrauterine device loaded with said encapsulated elements.

2. The retrievable intrauterine device according to claim 1, wherein said device is provided with at least one housing in which said encapsulated element(s) is/are loaded.

3. The retrievable intrauterine device according to claim 1 or 2, wherein said element is selected from the group comprising :
- agent capable of treating the uterus,
- agent capable of treating any pathology,
- tissues, cells or cell line secreting one or more agents,
- somatic cells,
- stem cells,
- recombinant viruses as gene transfer vehicle,
- sens or antisens mRNA sequences,
- male and/or female gametes,
- fertilized oocyte,
- unfertilized egg,
and any combination thereof.

4. The retrievable intrauterine device according to claim 3, wherein the agent capable of treating the uterus is selected from the group comprising:
- agent capable of preparing the uterine wall for optimal embryo implantation, - agent capable of preparing the uterine wall for optimal egg culture,
- agent capable of therapeutically treating the uterus,
- contraceptive agent.

5. The retrievable intrauterine device according to claim 3, wherein the at least one agent secreted by tissues, cells or cell line is selected from the group comprising drugs, hormones, nutrients, peptides, proteins, antibodies, trophic factors, growth factors, lymphokines, cytokines, enzymes, blood coagulation factors, angiogenesis factors, neurotransmitters, neuromodulators.
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6. The retrievable intrauterine device according to claim 4, wherein the agent capable of therapeutically treating the uterus is selected from the group comprising anti-inflammatory agents, amino acids, fatty acids, antibodies, trophic factors, growth factors, lymphokines, cytokines, enzymes, proteins, 75 peptides, blood coagulation factors, angiogenesis factors, analgesics, neurotransmitters, neuromodulators, anxiolytics, antidepressant, antibiotics, sens or antisens mRNA sequences, recombinant viruses as gene transfer vehicle.

20 7. The retrievable intrauterine device according to claim 3, wherein the at least one agent is secreted by tissues, cells or cell line are genetically modified.

8. The retrievable intrauterine device according to anyone of the preceding claims, wherein said element is capable of treating cancers, forms of 25 reproductive system cancers, reproductive diseases and uterine diseases such as endometriosis, adenomyosis, bleeding disorders and various infections.

9. A method of preparing a retrievable intrauterine device for placing within the uterine cavity one or more encapsulated elements capable of having interactions with the uterine fluid comprising the steps of:
- providing said element under the appropriate form to be encapsulated, - providing a retrievable intrauterine device suitable for receiving encapsulated element(s),
- loading said device with element(s).

10. A method for placing with the uterine cavity one or more encapsulated elements capable of having interactions with the uterine fluid comprising the steps of:
- providing a retrievable intrauterine device as defined in one of claims 1 to 6,
- implanting said device within the uterus cavity for a determined duration.

11. The method according to claim 10, wherein the at least one encapsulated element is placed within the uterine cavity of a mammal.

12. The method according to claim 10 or 11, wherein the mammal is selected from the group comprising: bovine, ovine, porcine, horses and humans.