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1. (WO2002094848) TRAITEMENT DU BACILLE DE KOCH AU MOYEN D'OLIGONUCLEOTIDES ANTISENS
Dernières données bibliographiques dont dispose le Bureau international   

N° de publication :    WO/2002/094848    N° de la demande internationale :    PCT/US2002/015963
Date de publication : 28.11.2002 Date de dépôt international : 20.05.2002
Demande présentée en vertu du Chapitre 2 :    04.11.2002    
CIB :
A61K 38/00 (2006.01), C12N 15/11 (2006.01)
Déposants : THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 111 Franklin Street, 12th Floor, Oakland, CA 94607 (US) (Tous Sauf US).
HORWITZ, Marcus, A. [US/US]; (US) (US Seulement).
HARTH, Gunter [DE/US]; (US) (US Seulement).
ZAMECNIK, Paul, C. [US/US]; (US).
TABATADZE, David [US/US]; (US)
Inventeurs : HORWITZ, Marcus, A.; (US).
HARTH, Gunter; (US).
ZAMECNIK, Paul, C.; (US).
TABATADZE, David; (US)
Mandataire : WOOD, William, J.; Gates and Cooper LLP, Suite 1050, 6701 Center Drive West, Los Angeles, CA 90045 (US)
Données relatives à la priorité :
60/292,096 18.05.2001 US
Titre (EN) TREATMENT OF MYCOBACTERIUM TUBERCULOSIS WITH ANTISENSE OLIGONUCLEOTIDES
(FR) TRAITEMENT DU BACILLE DE KOCH AU MOYEN D'OLIGONUCLEOTIDES ANTISENS
Abrégé : front page image
(EN)Methods of inhibiting the proliferation of Mycobacterium tuberculosis comprising contacting Mycobacterium tuberculosis with an effective amount of a polynucleotide complementary to an mRNA transcript expressed by Mycobacterium tuberculosis are provided. Typical methods of the invention utilize phosphorothioate modified antisense polynucleotides (PS-ODNs) against the mRNA of M.tuberculosis genes such as glutamine synthetase, aroA, ask, groES, and the genes of the Antigen 85 complex. Optionally, the methods employ multiple antisense polynucleotides targeting different Mycobacterium tuberculosis transcripts. In preferred embodiments of the invention, the antisense polynucleotides are complementary to the 5' regions of the Mycobacterium tuberculosis transcripts.
(FR)Methods of inhibiting the proliferation of <i>Mycobacterium tuberculosis</i> comprising contacting <i>Mycobacterium tuberculosis</i> with an effective amount of a polynucleotide complementary to an mRNA transcript expressed by <i>Mycobacterium tuberculosis</i> are provided. Typical methods of the invention utilize phosphorothioate modified antisense polynucleotides (PS-ODNs) against the mRNA of <i>M.tuberculosis</i> genes such as glutamine synthetase, <i>aroA, ask, groES</i>, and the genes of the Antigen 85 complex. Optionally, the methods employ multiple antisense polynucleotides targeting different <i>Mycobacterium tuberculosis</i> transcripts. In preferred embodiments of the invention, the antisense polynucleotides are complementary to the 5' regions of the <i>Mycobacterium tuberculosis</i> transcripts.
États désignés : AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
Organisation régionale africaine de la propriété intellectuelle (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Office eurasien des brevets (OEAB) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
Office européen des brevets (OEB) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
Organisation africaine de la propriété intellectuelle (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Langue de publication : anglais (EN)
Langue de dépôt : anglais (EN)