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1. (WO1999035116) CERTAINS DITERPENES ET EXTRAITS OU CONCENTRES DE CURCUMA AMADA CONTENANT CEUX-CI, UTILES COMME MEDICAMENTS
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

PATENT CLAIMS

1. A compound of formula I:



1 2
wherein R and R are independently CH2OH or CHO, for use as a medicament.

2 . An extract or concentrate of Curcuma amada comprising at least one compound of formula I as defined in claim 1.

3. An extract or concentrate of Curcuma amada according to claim 2, which further comprises at least one compound selected from the group consisting of ocimene, dihydro-ocimene, α-pinene, α-curcumene, β-curcumene, linalool, cuminyl alcohol, keto-alcohol, turmerone, linalyl acetate, safrole, car-3-ene, myrcene, 1,8-cineol, limonene and perillene.

4. A pharmaceutical composition containing at least one compound of formula I as defined in claim 1 or an extract or concentrate of Curcuma amada according to claim 2 or 3 and a pharmaceutically acceptable carrier.

5. A pharmaceutical composition according to claim 4, which further comprises γ-linolenic acid or eicosapen-taenoic acid.

6. A pharmaceutical composition according to claim 4 or

5. which is in the form of a dietary supplement.

7. A pharmaceutical composition according to claim 4 or 5, which is in the form of a cosmetic.

8. The use of a compound of formula I as defined in claim 1 or an extract or concentrate of Curcuma amada according to claim 2 or 3 for preparing a medicament for immunomodulation .

9. The use of a compound of formula I as defined in claim 1 or an extract or concentrate of Curcuma amada according to claim 2 or 3 for preparing a medicament for the suppression of hypersensitivity or inflammatory reactions .

10. The use according to claim 9 wherein the medicament is for the treatment or prevention of hypersensitivity skin diseases .

11. The use according to claim 10 wherein the medicament is for the treatment or prevention of atopic eczema, con-tact dermatitis, seborrhoeic eczema or psoriasis.

12. The use according to claim 9 wherein the medicament is for the treatment or prevention of IgE mediated allergic reactions and conditions .

13. The use according to claim 12 wherein the medicament is for the treatment or prevention of asthma, allergic rhinitis or anaphylaxis .

14. The use according to claim 8 or 9 wherein the medicament is for the treatment or prevention of autoimmune diseases or inflammatory diseases .

15. The use according to claim 14 wherein the medicament is for the treatment or prevention of Crohn's disease, ulcerative colitis, rheumatoid arthritis or osteoarthri-tis .

16. The use of a compound of formula I as defined in claim 1 or an extract or concentrate of Curcuma amada ac- cording to claim 2 or 3 for preparing a medicament for the alleviation of pain.

17. The use according to any one of claims 8-16 wherein the medicament is in the form of a dietary supplement.

18. The use according to any one of claims 8-16 wherein the medicament is in the form of a cosmetic .

19. A method for the treatment or prevention of a hypersensitivity disease in an individual, which comprises administering a compound of formula I as defined in claim 1 or an extract or concentrate of Curcuma amada according to claim 2 or 3 to said individual.

20. A method for the treatment or prevention of an autoimmune disease or an inflammatory disease in an individual, which comprises administering a compound of formula I as defined in claim 1 or an extract or concentrate of Curcuma amada according to claim 2 or 3 to said individual .

21. A method for the treatment or prevention of an IgE mediated allergic reaction or condition in an individual, which comprises administering a compound of formula I as defined in claim 1 or an extract or concentrate of Curcuma amada according to claim 2 or 3 to said individual.

22. A method for the alleviation of pain in an individual, which comprises administering a compound of formula I as defined in claim 1 or an extract or concentrate of Curcuma amada according to claim 2 or 3 to said individual .

23. A method of preparing an extract of Curcuma amada, which comprises distilling fresh or dried Curcuma amada or parts thereof, preferably the rhizome, and/or extracting said plant material with an extraction agent compris- ing an organic solvent or a mixture of organic solvents or mixtures thereof with water and subsequently, if necessary, removing the extraction agent to obtain an extract suitable for utilisation.

24. A method according to claim 23, wherein said solvent is a water miscible organic solvent selected from the group consisting of acetone, methyl ethyl ketone, ethyl acetate and lower alkanols having 1 to 4 carbon atoms .

25. A method according to claim 23, wherein said solvent is a water immiscible organic solvent, preferably selected from the group consisting of alkanes .

26. A method according to any one of claims 23-25, wherein the extract is further subjected to steam distillation, vacuum distillation column chromatography, or liquid-liquid extraction with a water immiscible organic solvent for the removal or concentration of certain constituents .