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1. WO1999001738 - FACTEUR DE CROISSANCE EPIDERMIQUE FIXANT L'HEPARINE DANS LE DIAGNOSTIC DE LA CYSTITE INTERSTITIELLE

Considéré comme nul:  12.08.1999
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]

WHAT IS CLAIMED:
1 . A method for diagnosing Interstitial Cystitis (IC) in a patient suffering from bladder dysfunction comprising the steps of:
(a) measuring the levels of heparin binding epithelial growth factor (HB-EGF) in the urine sample of said patient; and
(b) comparing said level with normal levels.
2. A method of claim 1 wherein said measurement step involves recombinant HB-EGF.

3. A method of claim 1 wherein said measurement step involves the use of anti-HB-EGF antibodies.
4. A method of claim 1 wherein said measurement step involves a biologic assay.
5. A method of claim 1 wherein said measurement step involves an immunoassay.
6. A method of claim 5 wherein said immunoassay is an enzyme linked immunosorbent assay or ELISA.
7. A method of claim 5 wherein said immunoassay is a radioimmunoassay or RIA. 8. A method of claim 1 wherein said step (b) further comprises correlating said level with a range associated with interstitial cystitis.
9 A diagnostic kit for use in diagnosing Interstitial Cystitis (IC) comprising:
(a) a means for measuring levels of HB-EGF in a sample of urine; and
(b) a means for indicating the whether the measurement in step (a) falls in a range associated with interstitial cystitis.
10. A kit of claim 9 wherein said means for measuring comprises a biologic assay.
11. A kit of claim 9 wherein said means for measuring comprises an immunoassay.
12. A diagnostic kit of claim 11 wherein said immunoassay is an ELISA.
13. A diagnostic kit of claim 11 wherein said immunoassay is an RIA.
14. A diagnostic kit for use in diagnosing Interstitial Cystitis (IC) comprising:
(a) an aliquot of anti-HB-EGF antibodies; and
(b) immunoassay reagents.

15. A diagnostic kit of claim 14 further comprising:
(c) a means for indicating whether a measurement of HB-EGF in urine correlates to the presence of Interstitial Cystitis.
16. A diagnostic kit of claim 14 wherein said immunoassay reagents are ELISA reagents. 17. A diagnostic kit of claim 14 wherein said immunoassay reagents are RIA reagents.