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1. (WO1993019037) COMPOSES
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

CLAIMS

A compound having the structural formula (I):


where Y and Y1 are independently hydrogen or hydroxyl, B and B1 are independently oxo or hydrogen, R5 is hydrogen or hydroxyl and X is the residue of an amino acid, joined to the ring shown via the nitrogen atom of the amino acid adjacent the acid group thereof, or a derivative of a said amino acid.

2. A compound according to Claim 1 wherein X is a group:
-N(R1)H-C(H) -R2
wherein R1 = CH2C6H4OH, -CH3, or -CH2OH and R2 = -COOC2H5, - COOCH3 or -CONHNH2, or a derivative thereof.

3. A compound according to Claim 2 wherein R1 = CH2OH and R2 = CONHNH2, or a derivative thereof.

4. A compound according to any one of the preceding claims wherein B

= B1 = oxo.

5. A compound according to any one of the preceding claims wherein Y = Y1 = H.

6. A pharmaceutical preparation comprising a pharmaceutically acceptable carrier and a compound according to any one of Claims 1 to 5.

7. A compound according to any one of Claims 1 to 5 for use in medicine.

8. The use of a compound according to any one of Claims 1 to 5 in the manufacture of a medicament for treating cancer in humans or mammals.

9. A dyestuff composition comprising a compound according to any one of Claims 1 to 5 and a dyestuff composition diluent, carrier or mordant.

10. A process for preparing a compound according to any one of Claims 1 to 5 comprising the steps of:

(a) oxidising the product obtainable by reacting leucoquinizarin or a 5'- OH, 8'-OH or 5' ,8'-(-OH)2 derivative thereof and an amino acid or derivative thereof having an -NH3 group alpha to a carboxyl group to join the amino acid or said derivative thereof to the leucoquinizarin ring at one of the carbonyl groups thereof; or

(b) converting one compound of Formula (I) to a second compound of

Formula (1).

11. A compound of formula (III):


wherein Y, Y1, R5 and X are as defined in Claim 1 and E and E1 are independently hydrogen or hydroxyl.