Recherche dans les collections de brevets nationales et internationales
Une partie du contenu de cette demande n'est pas disponible pour le moment.
Si cette situation persiste, contactez-nous auObservations et contact
1. (WO1993018789) COLORANTS NON AZOIQUES DE NAPHTALIMIDE ET UTILISATIONS__________
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

WHAT IS CLAIMED IS:

1. A non-azo N-substituted-1,8-naphthalimide compound substituted by, at a 3-position, a nucleofuge and, at a 4-position, a heteroatomic electron-releasing group, said heteroatomic electron-releasing group being characterized as having a heteroatom directly linked to said 4-position and having at least one hydrogen directly attached to said heteroatom, said non-azo N-substituted-1,8-naphthal imide compound being
characterized as predominantly hydrophobic and, after being activated by a sufficient amount of activating agent gives an activated derivative.

2. The compound of claim 1, wherein said
nucleofuge is a halogen, a sulfonate ester, or a nitrogen-containing leaving group.

3. The compound of claim 1, wherein said
heteroatom is nitrogen or oxygen.

4. The compound of claim 1, wherein said
activating agent is light energy, X-ray radiation, or thermalized neutron particles.

5. The compound of claim 1, wherein said
activating agent is light energy having a wavelength range of from about 200 nm to about 1000 nm.

6. The compound of claim 5, wherein said light energy has a wavelength range of from about 290 nm to about 750 nm.

7. The compound of claim 5, wherein said light energy has a wavelength range of from about 600 nm to about 750 nm.

8. The compound of claim 5, wherein said light energy has a wavelength range of from about 650 nm to about 700 nm.

9. The compound of claim 1, wherein said activated derivative is characterized as being
relatively non-toxic to normal tissues or normal cells at effective dosages yet can undergo photoinduced tautomeric alkylation with a target protein- based nucleophile.

10. A naphthalimide compound having the formula



which is a mixture of stereoisomers
wherein:

R and R' :

saturated straight-chain or branched-chain alkyl, CnH2n+l (n=1-30);

partially or totally fluorinated saturated
straight-chain or branched-chain alkyl,
CnHqF2n-q+l (n=1-30, 0≤q≤2n);

unsaturated straight-chain or branched-chain
alkyl, CnH2m+l (n=1-30, l≤m<n);

partially or totally fluorinated unsaturated
straight-chain or branched-chain alkyl,
CnHqF2m-q+l (n=1-30, l≤m<n, 0≤q≤2m);

alicyclic (monocyclic or polycyclic, fused-ring, bridged-ring or spirocyclic) alkyl, CnH2m+l
(n=1-30, l≤m≤n) with saturated or unsaturated side-chains (branched or unbranched);

partially or totally fluorinated alicyclic
(monocyclic or polycyclic,. fused-ring,
bridged-ring or spirocyclic) alkyl, CnHqF2m- q+l (n=1-30, l≤m<n, 0≤q≤2m) with saturated or unsaturated side-chains (branched or
unbranched);

aryl substituted branched, unbranched or
alicyclic, saturated or unsaturated alkyl,
ArCnH2m+l (n=1-30, 1≤m≤n), where Ar is an
aromatic moiety (benzene, naphthalene,
azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

partially or totally fluorinated aryl substituted branched, unbranched or alicyclic, saturated or unsaturated alkyl, ArCnHqF2m-q+l (n=1-30, l≤m≤n, 0≤q≤2m), where Ar is an aromatic
moiety (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

substituted saturated straight-chain or branched- chain alkyl, CnH2n-p+lYp (n=1-30, l≤p≤10)
where Y is a substituted aryl group (benzene, naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
straight-chain or branched-chain alkyl,
CnHqF2n-p-q+lYp (n=1-30, l≤p≤10 0≤q≤2n);

substituted unsaturated straight-chain or
branched-chain alkyl, CnH2m-p+lYp (n=1-30, l≤m<n, l≤p≤10) where Y is a substituted aryl group (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl.

aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
straight-chain or branched-chain alkyl,
CnHqF2m-p-q+lYp (n=1-30, l≤m<n, l≤p≤10,
0≤q≤2m) ;

substituted alicyclic (monocyclic or polycyclic, fused-ring, bridged-ring or spirocyclic)
alkyl, CnH2m+l (n=1-30, l≤m≤n) with saturated or unsaturated side-chains (branched or
unbranched) where Y is a substituted aryl
group (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
alicyclic (monocyclic or polycyclic, fused- ring, bridged-ring or spirocyclic) alkyl,
CnHqF2m-p-q+lYp (n=1-30, l≤m<n, l≤p≤10,
0≤q≤2m) with saturated or unsaturated side- chains (branched or unbranched) where Y is a substituted aryl group (benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted aryl substituted branched, unbranched or alicyclic, saturated or unsaturated alkyl,

ArCnH2m-p+lYp (n=1-30, 1≤m≤n, l≤p≤10), where Ar is an aromatic moiety (benzene,
naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus, and where Y is a substituted aryl group (defined above), a charged group
(CO2-, SO3-, PO32-, and ROPO22-), a silicon derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated aryl substituted branched, unbranched or
alicyclic, saturated or unsaturated alkyl,
ArCnHqF2m-p-q+lYp (n=1-30, 1≤m≤n, 1<P≤10,
0≤q≤2m), where Ar is an aromatic moiety
(benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus, and where Y is a substituted aryl group (defined above), a charged group
(CO2-, SO3-, PO32-, and ROPO22-), a silicon derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

a straight-chain or branched-chain group capable of complexing a metal ion, CnH2m+lYq (n=1-30, l≤q≤n, l≤q≤n/2), where Y is O, S, Se, NH, N- R, N-Ar, PH, P-R and/or P-Ar and their acyl
(including aminoacyl and peptide)
derivatives, and where R is saturated alkyl
(CnH2n+l, n=1-30), fluorinated saturated
alkyl (CnHqF2n-q+l, n=1-30, 0<q≤2n),
unsaturated alkyl (CnH2m+l, n=1-30, l≤m<n), fluorinated unsaturated alkyl (CnHqF2m-q+l, n=1-30, l≤m<n, 0≤q≤2m), alicyclic (CnH2m+l, n=1-30, l≤m≤n) , fluorinated alicyclic
(CnHqF2m-q+l, n=1-30, l≤m<n, 0≤q≤2m), and
where Ar is an aromatic moiety (benzene,
naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

a substituted alicyclic group capable of
complexing a metal ion, CnH2m+lYq (n=1-30, l≤q≤n, l≤q≤n/2), where Y is O, S, Se, NH, N- R, N-Ar, PH, P-R and/or P-Ar and their acyl
(including aminoacyl and peptide)
derivatives, and where R is saturated alkyl
(CnH2n+l, n=1-30), fluorinated saturated
alkyl (CnHqF2n-q+l, n=1-30, 0≤q≤2n),
unsaturated alkyl (CnH2m+l, n=1-30, l≤m<n), fluorinated unsaturated alkyl (CnHqF2m-q+l, n=1-30, l≤m<n, 0≤q≤2m), alicyclic (CnH2m+l, n=1-30, l≤m≤n), fluorinated alicyclic
(CnHqF2m-q+l, n=1-30, l≤m<n, 0≤q<2m), and
where Ar is an aromatic moiety (benzene,
naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus; or

a modified or unmodified biomolecule ( steroids, phospholipids, mono-, di- and triglycerides, mono- and polysaccharides, nucleosides, and polypeptides), where Y is a substituted aryl group (defined above), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a silicon
derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a biocompatible oligomer or polymer (polyglycolic acid);

X:

halogen ( F , Cl , Br , I ) ;

sulfonate ester (alkanesulfonates, partially or
totally fluorinated alkanesulfonates,
arenesulfonates, and partially or totally
fluorinated arenesulfonates); or

a nitrogen leaving group (diazonium ion);

or pharmaceutically acceptable salts thereof.

11. A non-azo N-substituted-1,8-naphthalimide compound having at least two 1,8-naphthalimide moieties each substituted by, at a 3-position, a nucleofuge and, at a 4-position, a heteroatomic electron-releasing group, said heteroatomic electron-releasing group being characterized as having a heteroatom directly linked to said 4-position and having at least one hydrogen directly attached to said heteroatom, said non-azo N-substituted-1,8-naphthalimide compound being
characterized as predominantly hydrophobic and, after being activated by a sufficient amount of activating agent, gives an activated derivative.

12. The compound of claim 11 wherein said
nucleofuge is a halogen, a sulfonate ester, or a nitrogen-containing leaving group.

13. The compound or claim 11, wherein said heteroatom is nitrogen or oxygen.

14. The compound of claim 11, wherein said activating agent is light energy, X-ray radiation, or thermalized neutron particles.

15. The compound of claim 11, wherein said activating agent is light energy having a wavelength range of from about 200 nm to about 1000 nm.

16. The compound of claim 15, wherein said light energy has a wavelength range of from about 290 nm to about 750 nm.

17. The compound of claim 15, wherein said light energy has a wavelength range of from about 600 nm to about 750 nm.

18. The compound of claim 15, wherein said light energy has a wavelength range of from about 650 nm to about 700 nm.

19. The compound of claim 11, wherein said activated derivative is characterized as being relatively non-toxic to normal tissues or normal cells at effective dosages yet can undergo photoinduced tautomeric alkylation with a target protein-based nucleophile.

20. A bis-naphthalimide compound having the formula



which is a mixture of stereoisomers
wherein:

R and R' :

saturated straight-chain or branched-chain alkyl, CnH2n+l (n=1-30);

partially or totally fluorinated saturated
straight-chain or branched-chain alkyl,
CnHqF2n-q+l (n=1-30, 0<q<2n);

unsaturated straight-chain or branched-chain
alkyl, CnH2m+l (n=1-30, l≤m<n);

partially or totally fluorinated unsaturated
straight-chain or branched-chain alkyl,
CnHqF2m-q+l (n=1-30, l≤m<n, 0≤q≤2m);

alicyclic (monocyclic or polycyclic, fused-ring,
bridged-ring or spirocyclic) alkyl, CnH2m+l
(n=1-30, l≤m≤n) with saturated or unsaturated side-chains (branched or unbranched);

partially or totally fluorinated alicyclic
(monocyclic or polycyclic, fused-ring,
bridged-ring or spirocyclic) alkyl, CnHqF2m- q+l (n=1-30, l≤m<n, 0≤q≤2m ) with saturated or unsaturated side-chains (branched or
unbranched);

aryl substituted branched, unbranched or
alicyclic, saturated or unsaturated alkyl,
ArCnH2m+l (n=1-30, l≤m≤n), where Ar is an
aromatic moiety (benzene, naphthalene,
azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

partially or totally fluorinated aryl substituted branched, unbranched or alicyclic, saturated or unsaturated alkyl, ArCnHqF2m-q+l (n=1-30, l≤m≤n, 0≤q≤2m), where Ar is an aromatic
moiety (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

substituted saturated straight-chain or branched- chain alkyl, CnH2n-p+lYp (n=1-30, l≤p≤10)
where Y is a substituted aryl group (benzene, naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
straight-chain or branched-chain alkyl,
CnHqF2n-p-q+lYp (n=1-30, l≤p≤10 0≤q≤2n);

substituted unsaturated straight-chain or
branched-chain alkyl, CnH2m-p+lYp (n=1-30, l≤m<n, l≤p≤10) where Y is a substituted aryl group (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
straight-chain or branched-chain alkyl,
CnHqF2m-p-q+lYp (n=1-30, l≤m<n, l≤p≤10,
0≤q<2m) ;

substituted alicyclic (monocyclic or polycyclic, fused-ring, bridged-ring or spirocyclic)
alkyl, CnH2m+l (n=1-30, 1≤m≤n) with saturated or unsaturated side-chains (branched or
unbranched) where Y is a substituted aryl
group (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
alicyclic (monocyclic or polycyclic, fused- ring, bridged-ring or spirocyclic) alkyl,
CnHqF2m-p-q+lYp (n=1-30, l≤m<n, l≤p≤10,
0≤q<2m) with saturated or unsaturated side- chains (branched or unbranched) where Y is a substituted aryl group (benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted aryl substituted branched, unbranched or alicyclic, saturated or unsaturated alkyl, ArCnH2m-p+lYp (n=1-30, 1≤m≤n, l≤p≤10), where Ar is an aromatic moiety (benzene,
naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus, and where Y is a substituted aryl group (defined above), a charged group
(CO2-, SO3-, PO32-, and ROPO22-), a silicon derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated aryl substituted branched, unbranched or
alicyclic, saturated or unsaturated alkyl,
ArCnHqF2m-p-q+lYp (n=1-30, 1≤m≤n, l≤p≤10,
0≤q≤2m), where Ar is an aromatic moiety
(benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus, and where Y is a substituted aryl group (defined above), a charged group
(CO2-, SO3-, PO32-, and ROPO22-), a silicon derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

a straight-chain or branched-chain group capable of complexing a metal ion, CnH2m+lYq (n=1-30, l≤q≤n, l≤q≤n/2), where Y is O, S, Se, NH, N- R, N-Ar, PH, P-R and/or P-Ar and their acyl
(including aminoacyl and peptide)
derivatives, and where R is saturated alkyl
(CnH2n+l, n=1-30), fluorinated saturated
alkyl (CnHqF2n-q+l, n=1-30, 0≤q≤2n),
unsaturated alkyl (CnH2m+l, n=1-30, l≤m<n), fluorinated unsaturated alkyl (CnHqF2m-q+l, n=1-30, l≤m<n, 0≤q≤2m), alicyclic (CnH2m+l, n=1-30, l≤m≤n), fluorinated alicyclic
(CnHqF2m-q+l, n=1-30, l≤m<n, 0≤q≤2m), and
where Ar is an aromatic moiety (benzene,
naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

a substituted alicyclic group capable of
complexing a metal ion, CnH2m+lYq (n=1-30, l≤q≤n, l≤q≤n/2), where Y is O, S, Se, NH, N- R, N-Ar, PH, P-R and/or P-Ar and their acyl
(including aminoacyl and peptide)
derivatives, and where R is saturated alkyl
(CnH2n+l, n=1-30), fluorinated saturated
alkyl (CnHqF2n-q+l, n=1-30, 0≤q≤2n),
unsaturated alkyl (CnH2m+l, n=1-30, l≤m<n), fluorinated unsaturated alkyl (CnHqF2m-q+l, n=1-30, l≤m<n, 0≤q≤2m), alicyclic (CnH2m+l, n=1-30, l≤m≤n), fluorinated alicyclic
(CnHqF2m-q+l, n=1-30, l≤m<n, 0≤q≤2m), and
where Ar is an aromatic moiety (benzene,
naphthalene , azulene , phenanthrene ,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus; or a modified or unmodified biomolecule (steroids,
phospholipids, mono-, di- and triglycerides, mono- and polysaccharides, nucleosides, and
polypeptides), where Y is a substituted aryl group (defined above), a charged group (CO2-,

SO3-, PO32-, and ROPO22-), a silicon
derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a biocompatible oligomer or polymer (polyglycolic acid);

X:

halogen (F, Cl, Br, I)

sulfonate ester (alkanesulfonates, partially or
totally fluorinated alkanesulfonates,
arenesulfonates, and partially or totally
fluorinated arenesulfonates); or

a nitrogen leaving group (diazonium ion);

Q:

saturated straight-chain or branched-chain alkyl, CnH2n (n=1-30);

partially or totally fluorinated saturated
straight-chain or branched-chain alkyl,
CnHqF2n-q (n=1-30, 0≤q≤2n);

unsaturated straight-chain or branched-chain
alkyl, CnH2m (n=1-30, l≤m<n);

partially or totally fluorinated unsaturated
straight-chain or branched-chain alkyl,
CnHqF2m-q (n=1-30, l≤m<n, 0≤q≤2m);

alicyclic (monocyclic or polycyclic, fused-ring, bridged-ring or spirocyclic) alkyl, CnH2m
(n=1-30, l≤m≤n) with saturated or unsaturated side-chains (branched or unbranched);

partially or totally fluorinated alicyclic
(monocyclic or polycyclic, fused-ring,
bridged-ring or spirocyclic) alkyl, CnHqF2m-q

(n=1-30, l≤m<n, 0≤q≤2m) with saturated or
unsaturated side-chains (branched or
unbranched);

aryl substituted branched, unbranched or
alicyclic, saturated or unsaturated alkyl,
ArCnH2m (n=1-30, l≤m≤n), where Ar is an
aromatic moiety (benzene, naphthalene,
azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

partially or totally fluorinated aryl substituted branched, unbranched or alicyclic, saturated or unsaturated alkyl, ArCnHqF2m-q (n=1-30, l≤m≤n, 0≤q<2m), where Ar is an aromatic
moiety (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

substituted saturated straight-chain or branched- chain alkyl, CnH2n-pYp (n=1-30, l≤P≤10) where Y is a substituted aryl group (benzene,
naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
straight-chain or branched-chain alkyl,
CnHqF2n-p-qYp (n=1-30, l≤P≤10 0≤q≤2n);

substituted unsaturated straight-chain or
branched-chain alkyl, CnH2m-pYp (n=1-30,
l≤m<n, l≤p≤10) where Y is a substituted aryl group (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
straight-chain or branched-chain alkyl,
CnHqF2m-p-qYp (n=1-30, l≤m<n, l≤p≤10,
0≤q≤2m);

substituted alicyclic (monocyclic or polycyclic, fused-ring, bridged-ring or spirocyclic)
alkyl, CnH2m (n=1-30, l≤m≤n) with saturated or unsaturated side-chains (branched or
unbranched) where Y is a substituted aryl
group (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
alicyclic (monocyclic or polycyclic, fused- ring, bridged-ring or spirocyclic) alkyl,
CnHqF2m-p-qYp (n=1-30, l≤m<n, l≤p≤10, 0≤q≤2m) with saturated or unsaturated side-chains
(branched or unbranched) where Y is a
substituted aryl group (benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted aryl substituted branched, unbranched or alicyclic, saturated or unsaturated alkyl,

ArCnH2m-pYp (n=1-30, l≤m≤n, l≤p≤10), where Ar is an aromatic moiety (benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus, and where Y is a substituted aryl group (defined above), a charged group
(CO2-, SO3-, PO32-, and ROPO22-), a silicon derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated aryl substituted branched, unbranched or
alicyclic, saturated or unsaturated alkyl,
ArCnHqF2m-p-qYp (n=1-30, l≤m≤n, l≤p≤10,
0≤q≤2m), where Ar is an aromatic moiety
(benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus, and where Y is a substituted aryl group (defined above), a charged group
(CO2-, SO3-, PO32-, and ROPO22-), a silicon derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

a straight-chain or branched-chain group capable of complexing a metal ion, CnH2mYq (n=1-30, l≤q≤n, l≤q≤n/2), where Y is O, S, Se, NH, N- R, N-Ar, PH, P-R and/or P-Ar and their acyl
(including aminoacyl and peptide)
derivatives, and where R is saturated alkyl
(CnH2n, n=1-30), fluorinated saturated alkyl (CnHqF2n-q, n=1-30, 0≤q≤2n), unsaturated
alkyl (CnH2m, n=1-30, l≤m<n), fluorinated
unsaturated alkyl (CnHqF2m-q, n=1-30, l≤m<n, 0≤q≤2m), alicyclic (CnH2πu n=1-30, l≤m≤n), fluorinated alicyclic (CnHqF2m-q, n=1-30,
l≤m<n, 0≤q≤2m), and where Ar is an aromatic moiety (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

a substituted alicyclic group capable of
complexing a metal ion, CnH2mYq (n=1-30,
l≤q≤n, l≤q≤n/2), where Y is 0, S, Se, NH, N- R, N-Ar, PH, P-R and/or P-Ar and their acyl
(including aminoacyl and peptide)
derivatives, and where R is saturated alkyl
(CnH2n, n=1-30), fluorinated saturated alkyl (CnHqF2n-q, n=1-30, 0≤q≤2n), unsaturated
alkyl (CnH2m, n=1-30, l≤m<n), fluorinated
unsaturated alkyl (CnHqF2m-q, n=1-30, l≤m<n, 0≤q<2m), alicyclic (CnH2m, n=1-30, l≤m≤n),
fluorinated alicyclic (CnHqF2m-q, n=1-30,
l≤m<n, 0≤q≤2m), and where Ar is an aromatic
moiety (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located
either within the chain of the alkyl group or at a terminus; or

a modified or unmodified biomolecule ( steroids,
phospholipids, mono-, di- and triglycerides, mono- and polysaccharides, nucleosides, and
polypeptides), where Y is a substituted aryl group (defined above), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a silicon
derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a biocompatible oligomer or polymer (polyglycolic acid); or pharmaceutically acceptable salts thereof.

21. A bis-naphthalimide compound having the formula



which is a mixture of stereoisomers
wherein:

R and R' :

saturated straight-chain or branched-chain alkyl, CnH2n+l (n=1-30);

partially or totally fluorinated saturated
straight-chain or branched-chain alkyl,
CnHqF2n-q+l (n=1-30, 0≤q≤2n);

unsaturated straight-chain or branched-chain
alkyl, CnH2m+l (n=1-30, l≤m<n);

partially or totally fluorinated unsaturated
straight-chain or branched-chain alkyl,
CnHqF2m-q+l (n=1-30, l≤m<n, 0≤q≤2m);

alicyclic (monocyclic or polycyclic, fused-ring,
bridged-ring or spirocyclic) alkyl, CnH2m+l
(n=1-30, l≤m≤n) with saturated or unsaturated side-chains (branched or unbranched);

partially or totally fluorinated alicyclic
(monocyclic or polycyclic, fused-ring,
bridged-ring or spirocyclic) alkyl, CnHqF2m- q+1 (n=1-30, l≤m<n, 0≤q≤2m) with saturated or unsaturated side-chains (branched or
unbranched);

aryl substituted branched, unbranched or
alicyclic, saturated or unsaturated alkyl,
ArCnH2m+l (n=1-30, l≤m≤n), where Ar is an
aromatic moiety (benzene, naphthalene,
azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

partially or totally fluorinated aryl substituted branched, unbranched or alicyclic, saturated or unsaturated alkyl, ArCnHqF2m-q+l (n=1-30, 1≤m≤n, 0≤q≤2m), where Ar is an aromatic
moiety (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

substituted saturated straight-chain or branched- chain alkyl, CnH2n-p+lYq (n=1-30, l≤p≤10)
where Y is a substituted aryl group (benzene, naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
straight-chain or branched-chain alkyl,
CnHqF2n-p-q+lYq (n=1-30, l≤p≤10 0≤q≤2n);

substituted unsaturated straight-chain or
branched-chain alkyl, CnH2m-p+lYp (n=1-30, l≤m<n, L<p≤10) where Y is a substituted aryl group (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
straight-chain or branched-chain alkyl,
CnHqF2m-p-q+lYq (n=1-30, l≤m<n, l≤p≤10,
0≤q≤2m);

substituted alicyclic (monocyclic or polycyclic, fused-ring, bridged-ring or spirocyclic)
alkyl, CnH2m+l (n=1-30, l≤m≤n) with saturated or unsaturated side-chains (branched or unbranched) where Y is a substituted aryl
group (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
alicyclic (monocyclic or polycyclic, fused- ring, bridged-ring or spirocyclic) alkyl,
CnHqF2m-p-q+lYq (n=1-30, l≤m<n, l≤p≤10,
0<q<2m) with saturated or unsaturated side- chains (branched or unbranched) where Y is a substituted aryl group (benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted aryl substituted branched, unbranched or alicyclic, saturated or unsaturated alkyl, ArCnH2m-p+lYq (n=1-30, l≤m≤n, l≤p≤10), where Ar is an aromatic moiety (benzenee naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus, and where Y is a substituted aryl group (defined above), a charged group
(CO2-, SO3-, PO32-, and ROPO22-), a silicon derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated aryl substituted branched, unbranched or
alicyclic, saturated or unsaturated alkyl,
ArCnHqF2m-p-q+lYq (n=1-30, 1≤m≤n, l≤p≤10,
0≤q≤2m), where Ar is an aromatic moiety
(benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus, and where Y is a substituted aryl group (defined above), a charged group
(CO2-, SO3-, PO32-, and ROPO22-), a s ilico derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

a straight-chain or branched-chain group capable of complexing a metal ion, CnH2m+lYq (n=1-30, l≤q≤n, l≤q≤n/2), where Y is O, S, Se, NH, N- R, N-Ar, PH, P-R and/or P-Ar and their acyl
(including aminoacyl and peptide)
derivatives, and where R is saturated alkyl
(CnH2n+l, n=1-30), fluorinated saturated
alkyl (CnHqF2n-q+l, n=1-30, 0≤q≤2n),
unsaturated alkyl (CnH2m+l, n=1-30, l≤m<n), fluorinated unsaturated alkyl (CnHqF2m-q+l, n=1-30, l≤m<n, 0≤q≤2m), alicyclic (CnH2m+l, n=1-30, 1≤m≤n), fluorinated alicyclic
(CnHqF2m-q+l, n=1-30, l≤m<n, 0≤q≤2m), and
where Ar is an aromatic moiety (benzene,
naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

a substituted alicyclic group capable of
complexing a metal ion, CnH2m+lYq (n=1-30, l≤q≤n, l≤q≤n/2), where Y is O, S, Se, NH, N- R, N-Ar, PH, P-R and/or P-Ar and their acyl
(including aminoacyl and peptide)
derivatives, and where R is saturated alkyl
(CnH2n+l, n=1-30), fluorinated saturated
alkyl (CnHqF2n-q+l, n=1-30, 0<q≤2n),
unsaturated alkyl (CnH2m+l, n=1-30, l≤m<n), fluorinated unsaturated alkyl (CnHqF2m-q+l, n=1-30, l≤m<n, 0≤q≤2m), alicyclic (CnH2m+l, n=1-30, l≤m≤n), fluorinated alicyclic (CnHqF2m-q+l, n=1-30, l≤m<n, 0≤q≤2m), and
where Ar is an aromatic moiety (benzene,
naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole,
indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located
either within the chain of the alkyl group or at a terminus; or

a modified or unmodified biomolecule (steroids,
phospholipids, mono-, di- and triglycerides, mono- and polysaccharides, nucleosides, and
polypeptides), where Y is a substituted aryl group (defined above), a charged group (CO2-,

SO3-, PO32-, and ROPO22-), a silicon
derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a biocompatible oligomer or polymer (polyglycolic acid);

X:

halogen (F, Cl, Br, I);

sulfonate ester (alkanesulfonates, partially or
totally fluorinated alkanesulfonates,
arenesulfonates, and partially or totally
fluorinated arenesulfonates); or

a nitrogen leaving group (diazonium ion);

Q :
saturated straight-chain or branched-chain alkyl, CnH2n (n=1-30);

partially or totally fluorinated saturated
straight-chain or branched-chain alkyl,
CnHqF2n-q (n=1-30, 0<q<2n);

unsaturated straight-chain or branched-chain
alkyl, CnH2m (n=1-30, l≤m<n);

partially or totally fluorinated unsaturated
straight-chain or branched-chain alkyl,
CnHqF2m-q (n=1-30, l≤m<n, 0≤q≤2m);

alicyclic (monocyclic or polycyclic, fused-ring,
bridged-ring or spirocyclic) alkyl, CnH2m
(n=1-30, l≤m≤n) with saturated or unsaturated side-chains (branched or unbranched);

partially or totally fluorinated alicyclic
(monocyclic or polycyclic, fused-ring,
bridged-ring or spirocyclic) alkyl, CnHqF2m-q (n=1-30, l≤m<n, 0≤q≤2m) with saturated or
unsaturated side-chains (branched or
unbranched);

aryl substituted branched, unbranched or
alicyclic, saturated or unsaturated alkyl,
ArCnH2m (n=1-30, l≤m≤n), where Ar is an
aromatic moiety (benzene, naphthalene,
azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

partially or totally fluorinated aryl substituted branched, unbranched or alicyclic, saturated or unsaturated alkyl, ArCnHqF2m-q (n=1-30,
1≤m≤n, 0≤q≤2m), where Ar is an aromatic
moiety (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

substituted saturated straight-chain or branched- chain alkyl, CnH2n-pYq (n=1-30, l≤p≤10) where Y is a substituted aryl group (benzene,
naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo) , or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
straight-chain or branched-chain alkyl,
CnHqF2n-p-qYq (n=1-30, l≤p≤10 0≤q≤2n);

substituted unsaturated straight-chain or
branched-chain alkyl, CnH2m-pYq (n=1-30,
l≤m<n, l≤p≤10) where Y is a substituted aryl group (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
straight-chain or branched-chain alkyl,
CnHqF2m-p-qYq (n=1-30, l≤m<n, l≤p≤10,
0≤q≤2m);

substituted alicyclic (monocyclic or polycyclic, fused-ring, bridged-ring or spirocyclic)
alkyl, CnH2m (n=1-30, l≤m≤n) with saturated or unsaturated side-chains (branched or
unbranched) where Y is a substituted aryl
group (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
alicyclic (monocyclic or polycyclic, fused- ring, bridged-ring or spirocyclic) alkyl,
CnHqF2m-p-qYq (n=1-30, l≤m<n, l≤p≤10, 0≤q≤2m) with saturated or unsaturated side-chains
(branched or unbranched) where Y is a
substituted aryl group (benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted aryl substituted branched, unbranched or alicyclic, saturated or unsaturated alkyl, ArCnH2m-pYp (n=1-30, l≤m≤n, l≤p≤10), where Ar is an aromatic moiety (benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus, and where Y is a substituted aryl group (defined above), a charged group
(CO2-, SO3-, PO32-, and ROPO22-), a silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated aryl substituted branched, unbranched or
alicyclic, saturated or unsaturated alkyl,
ArCnHqF2m-p-qYq (n=1-30, 1≤m≤n, l≤p≤10,
0≤q≤2m), where Ar is an aromatic moiety
(benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus, and where Y is a substituted aryl group (defined above), a charged group
(CO2-, SO3-, PO32-, and ROPO22-), a silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

a straight-chain or branched-chain group capable of complexing a metal ion, CnH2mYq (n=1-30, l≤q≤n, l≤q≤n/2), where Y is O, S, Se, NH, N- R, N-Ar, PH, P-R and/or P-Ar and their acyl
(including aminoacyl and peptide)
derivatives, and where R is saturated alkyl
(CnH2n, n=1-30), fluorinated saturated alkyl (CnHqF2n-q, n=1-30, 0≤q≤2n), unsaturated
alkyl (CnH2m, n=1-30, l≤m<n), fluorinated
unsaturated alkyl (CnHqF2m-q, n=1-30, l≤m<n, 0≤q≤2m), alicyclic (CnH2m, n=1-30, l≤m≤n), fluorinated alicyclic (CnHqF2m-q, n=1-30,
l≤m<n, 0≤q≤2m), and where Ar is an aromatic moiety (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

a substituted alicyclic group capable of
complexing a metal ion, CnH2mYq (n=1-30,
l≤q≤n, l≤q≤n/2), where Y is O, S, Se, NH, N- R, N-Ar, PH, P-R and/or P-Ar and their acyl
(including aminoacyl and peptide)
derivatives, and where R is saturated alkyl
(CnH2n, n=1-30), fluorinated saturated alkyl (CnHqF2n-q, n=1-30, 0≤q≤2n), unsaturated
alkyl (CnH2m, n=1-30, l≤m<n), fluorinated
unsaturated alkyl (CnHqF2m-q, n=1-30, l≤m<n, 0≤q≤2m), alicyclic (CnH2m, n=1-30, l≤m≤n), fluorinated alicyclic (CnHqF2m-q, n=1-30,
l≤m<n, 0≤q≤2m), and where Ar is an aromatic moiety (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus; or

a modified or unmodified biomolecule ( steroids, phospholipids, mono-, di- and triglycerides, mono- and polysaccharides, nucleosides, and
polypeptides), where Y is a substituted aryl group (defined above), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a silicon
derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a biocompatible oligomer or polymer (polyglycolic acid); or pharmaceutically acceptable salts thereof.

22. A bis-naphthalimide compound having the formula



which is a mixture of stereoisomers
wherein:

R and R':

saturated straight-chain or branched-chain alkyl, CnH2n+l (n=1-30);

partially or totally fluorinated saturated
straight-chain or branched-chain alkyl,
CnHqF2n-q+l (n=1-30, 0≤q≤2n);

unsaturated straight-chain or branched-chain
alkyl, CnH2m+l (n=1-30, l≤m<n);

partially or totally fluorinated unsaturated
straight-chain or branched-chain alkyl,
CnHqF2m-q+l (n=1-30, l≤m<n, 0≤q≤2m);

alicyclic (monocyclic or polycyclic, fused-ring, bridged-ring or spirocyclic) alkyl, CnH2m+l
(n=1-30, l≤m≤n) with saturated or unsaturated side-chains (branched or unbranched);

partially or totally fluorinated alicyclic
(monocyclic or polycyclic, fused-ring,
bridged-ring or spirocyclic) alkyl, CnHqF2m- q+l (n=1-30, l≤m<n, 0≤q≤2m) with saturated or unsaturated side-chains (branched or
unbranched);

aryl substituted branched, unbranched or
alicyclic, saturated or unsaturated alkyl,
ArCnH2m+l (n=1-30, l≤m≤n), where Ar is an
aromatic moiety (benzene, naphthalene,
azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

partially or totally fluorinated aryl substituted branched, unbranched or alicyclic, saturated or unsaturated alkyl, ArCnHqF2m-q+l (n=1-30, l≤m≤n, 0≤q≤2m), where Ar is an aromatic
moiety (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

substituted saturated straight-chain or branched- chain alkyl, CnH2n-p+lYq (n=1-30, l≤p≤10 )
where Y is a substituted aryl group (benzene, naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
straight-chain or branched-chain alkyl,
CnHqF2n-p-q+lYq (n=1-30, l≤p≤10 0≤q<2n);

substituted unsaturated straight-chain or
branched-chain alkyl, CnH2m-p+1Yp (n=1-30, l≤m<n, l≤P≤10) where Y is a substituted aryl group (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
straight-chain or branched-chain alkyl,
CnHqF2m-p-q+lYq (n=1-30, l≤m<n, l≤p≤10,
0≤q<2m) ;

substituted alicyclic (monocyclic or polycyclic, fused-ring, bridged-ring or spirocyclic)
alkyl, CnH2m+l (n=1-30, l≤m<n) with saturated or unsaturated side-chains (branched or
unbranched) where Y is a substituted aryl
group (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
alicyclic (monocyclic or polycyclic, fused- ring, bridged-ring or spirocyclic) alkyl,
CnHqF2m-p-q+lYq (n=1-30, l≤m<n, l≤P≤10,
0<q≤2m) with saturated or unsaturated side- chains (branched or unbranched) where Y is a substituted aryl group (benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative- (BZ2 , where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted aryl substituted branched, unbranched or alicyclic, saturated or unsaturated alkyl,

ArCnH2m-p+lYp (n=1-30, l≤m≤n, l≤p≤10), where Ar is an aromatic moiety (benzene,
naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus, and where Y is a substituted aryl group (defined above), a charged group
(CO2-, SO3-, PO32-, and ROPO22-), a silicon derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated aryl substituted branched, unbranched or
alicyclic, saturated or unsaturated alkyl,
ArCnHqF2m-p-q+1Yp (n=1-30, l≤m≤n, l≤p≤10,
0≤q≤2m), where Ar is an aromatic moiety
(benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus, and whore Y is a substituted aryl group (defined above), a charged group
(CO2-, SO3-, PO32-, and ROPO22-), a silicon derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

a straight-chain or branched-chain group capable of complexing a metal ion, CnH2m+1Yq (n=1-30, l≤q≤n, l≤q≤n/2), where Y is O, S, Se, NH, N- R, N-Ar, PH, P-R and/or P-Ar and their acyl
(including aminoacyl and peptide)
derivatives, and where R is saturated alkyl
(CnH2n+l, n=1-30), fluorinated saturated
alkyl (CnHqF2n-q+l, n=1-30, 0≤q≤2n),
unsaturated alkyl (CnH2m+l, n=1-30, l≤m<n), fluorinated unsaturated alkyl (CnHqF2m-q+l, n=1-30, l≤m<n, 0≤q≤2m), alicyclic (CnH2m+l, n=1-30, l≤m≤n), fluorinated alicyclic
(CnHqF2m-q+l, n=1-30, l≤m<n, 0≤q≤2m), and
where Ar is an aromatic moiety (benzene,
naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

a substituted alicyclic group capable of
complexing a metal ion, CnH2m+1Yq (n=1-30, l≤q≤n, l≤q≤n/2), where Y is O, S, Se, NH, N- R, N-Ar, PH, P-R and/or P-Ar and their acyl
(including aminoacyl and peptide)
derivatives, and where R is saturated alkyl
(CnH2n+1, n=1-30), fluorinated saturated
alkyl (CnHqF2n-q+1, n=1-30, 0<q≤2n),
unsaturated alkyl (CnH2m+1, n=1-30, l≤m<n), fluorinated unsaturated alkyl (CnHqF2m-q+l, n=1-30, l≤m<n, 0≤q≤2m) , alicyclic (CnH2m+l, n=1-30, l≤m≤n), fluorinated alicyclic
(CnHqF2m-q+l, n=1-30, l≤m<n, 0≤q≤2m ) , and
where Ar is an aromatic moiety (benzene,
naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus; or

a modified or unmodified biomolecule (steroids, phospholipids, mono-, di- and triglycerides, mono- and polysaccharides, nucleosides, and polypeptides), where Y is a substituted aryl group (defined above), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a silicon
derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a biocompatible oligomer or polymer (polyglycolic acid);

X:

halogen (F, Cl, Br, I);

sulfonate ester (alkanesulfonates, partially or
totally fluorinated alkanesulfonates,
arenesulfonates, and partially or totally
fluorinated arenesulfonates); or

a nitrogen leaving group (diazonium ion);

Q:
saturated straight-chain or branched-chain alkyl, CnH2n (n=1-30);

partially or totally fluorinated saturated
straight-chain or branched-chain alkyl,
CnHqF2n-q (n=1-30, 0<q≤2n);

unsaturated straight-chain or branched-chain
alkyl, CnH2m (n=1-30, l≤m<n);

partially or totally fluorinated unsaturated
straight-chain or branched-chain alkyl,
CnHqF2m-q (n=1-30, l≤m<n, 0≤q≤2m);

alicyclic (monocyclic or polycyclic, fused-ring,
bridged-ring or spirocyclic) alkyl, CnH2m
(n=1-30, l≤m≤n) with saturated or unsaturated side-chains (branched or unbranched);

partially or totally fluorinated alicyclic
(monocyclic or polycyclic, fused-ring,
bridged-ring or spirocyclic) alkyl, CnHqF2m-q

(n=1-30, l≤m<n, 0≤q≤2m) with saturated or
unsaturated "side-chains (branched or
unbranched);

aryl substituted branched, unbranched or
alicyclic, saturated or unsaturated alkyl,
ArCnH2m (n=1-30, l≤m≤n), where Ar is an
aromatic moiety (benzene, naphthalene,
azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

partially or totally fluorinated aryl substituted branched, unbranched or alicyclic, saturated or unsaturated alkyl, ArCnHqF2m-q (n=1-30, l≤m≤n, 0≤q≤2m), where Ar is an aromatic
moiety (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

substituted saturated straight-chain or branched- chain alkyl, CnH2n-pYp (n=1-30, 1≤p≤10) where

Y is a substituted aryl group (benzene,
naphthalene, azulene, phenanthrene,
anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and. their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
straight-chain or branched-chain alkyl,
CnHqF2n-p-qYp (n=1-30, l≤p≤10 0≤q≤2n);

substituted unsaturated straight-chain or
branched-chain alkyl, CnH2m-pYp (n=1-30,
l≤m<n, l≤p≤10) where Y is a substituted aryl group (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
straight-chain or branched-chain alkyl,
CnHqF2m-p-qYp (n=1-30, l≤m<n, l≤p≤10,
0≤q≤2m);

substituted alicyclic (monocyclic or polycyclic, fused-ring, bridged-ring or spirocyclic)
alkyl, CnH2m (n=1-30, l≤m≤n) with saturated or unsaturated side-chains (branched or
unbranched) where Y is a substituted aryl group (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated
alicyclic (monocyclic or polycyclic, fused- ring, bridged-ring or spirocyclic) alkyl,
CnHqF2m-p-qYp (n=1-30, l≤m<n, l≤p≤10, 0≤q≤2m) with saturated or unsaturated side-chains
(branched or unbranched) where Y is a
substituted aryl group (benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a
silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted aryl substituted branched, unbranched or alicyclic, saturated or unsaturated alkyl, ArCnH2m-pYp (n=1-30, l≤m≤n, l≤p≤10), where Ar is an aromatic moiety (benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus, and where Y is a substituted aryl group (defined above), a charged group
(CO2-, SO3-, PO32-, and ROPO22-), a silicon derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

substituted partially or totally fluorinated aryl substituted branched, unbranched or
alicyclic, saturated or unsaturated alkyl,
ArCnHqF2m-p-qYp (n=1-30, 1≤m≤n, l≤p≤10,
0≤q<2m), where Ar is an aromatic moiety
(benzene, naphthalene, azulene, phenanthrene, anthracene, pyridine, quinoline,
isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene,
imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus, and where Y is a substituted aryl group (defined above), a charged group
(CO2-, SO3-, PO32-, and ROPO22-), a silicon derivative (SiZ3, where Z is alkyl, aryl, alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo);

a straight-chain or branched-chain group capable of complexing a metal ion, CnH2mYq (n=1-30, l≤q≤n, l≤q≤n/2), where Y is O, S, Se, NH, N- R, N-Ar, PH, P-R and/or P-Ar and their acyl (including aminoacyl and peptide)
derivatives, and where R is saturated alkyl
(CnH2n, n=1-30), fluorinated saturated alkyl (CnHqF2n-q, n=1-30, 0≤q≤2n), unsaturated
alkyl (CnH2m, n=1-30, l≤m<n), fluorinated
unsaturated alkyl (CnHqF2m-q, n=1-30, l≤m<n, 0≤q≤2m), alicyclic (CnH2m, n=1-30, l≤m≤n), fluorinated alicyclic (CnHqF2m-q, n=1-30,
l≤m<n, 0≤q≤2m), and where Ar is an aromatic moiety (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located either within the chain of the alkyl group or at a terminus;

a substituted alicyclic group capable of
complexing a metal ion, CnH2mYq (n=1-30,
l≤q≤n, l≤q≤n/2), where Y is O, S, Se, NH, N- R, N-Ar, PH, P-R and/or P-Ar and their acyl
(including aminoacyl and peptide)
derivatives, and where R is saturated alkyl
(CnH2n, n=1-30), fluorinated saturated alkyl (CnHqF2n-q, n=1-30, 0≤q≤2n), unsaturated
alkyl (CnH2m, n=1-30, l≤m<n), fluorinated
unsaturated alkyl (CnHqF2m-q, n=1-30, l≤m<n, 0≤q≤2m), alicyclic (CnH2m, n=1-30, l≤m<n), fluorinated alicyclic (CnHqF2m-q, n=1-30,
l≤m<n, 0≤q≤2m), and where Ar is an aromatic moiety (benzene, naphthalene, azulene,
phenanthrene, anthracene, pyridine,
quinoline, isoquinoline, purine, pyrimidine, pyrrole, indole, carbazole, furan, thiophene, imidazole, isoxazole, thiazole and their
substituted and benzo derivatives) located
either within the chain of the alkyl group or at a terminus; or

a modified or unmodified biomolecule ( steroids,
phospholipids, mono-, di- and triglycerides, mono- and polysaccharides, nucleosides, and
polypeptides), where Y is a substituted aryl group (defined above), a charged group (CO2-, SO3-, PO32-, and ROPO22-), a silicon
derivative (SiZ3, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a boron
derivative (BZ2, where Z is alkyl, aryl,
alkoxy, aryloxy, or halo), or a biocompatible oligomer or polymer (polyglycolic acid); or pharmaceutically acceptable salts thereof.

23. A pharmaceutical composition for eradicating a pathogenic biological contaminant from body tissue, which comprises a therapeutically effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof, having been activated by a sufficient amount of an activating agent, as an active ingredient, in combination with a pharmaceutically acceptable carrier for said active ingredient.

24. The composition of claim 23 wherein said body tissue is body fluid, packed red blood cell, packed white blood cell, cryo precipitate from blood plasma, plasma protein, skin or cornea.

25. The composition of claim 24 wherein said body fluid is whole blood, blood plasma, serum, fluid from plasmapheresis, bone marrow or plasma fibrinogen.

26. The composition of claim 24 wherein said body fluid is albumin, gamma globulin or semen.

27. The composition of claim 23 wherein said body tissue is platelet.

28. The composition of claim 23 wherein said pathogenic biological contaminant is virus, tumor cell, bacterium or parasite.

29. A pharmaceutical composition for eradicating a pathogenic biological contaminant from body tissue, which comprises a therapeutically effective amount of a compound of claim 11, or a pharmaceutically acceptable salt thereof, having been activated by a sufficient amount of an activating agent, as an active ingredient, in combination with a pharmaceutically acceptable carrier for said active ingredient.

30. The composition of claim 29 wherein said body tissue is body fluid, packed red blood cell, packed white blood cell, cryo precipitate from blood plasma, plasma protein, skin or cornea.

31. The composition of claim 30 wherein said body fluid is whole blood, blood plasma, serum, fluid from plasmapheresis, bone marrow or plasma fibrinogen.

32. The composition of claim 30 wherein said body fluid is albumin, gamma globulin or semen.

33. The composition of claim 29 wherein said body tissue is platelet.

34. The composition of claim 29 wherein said pathogenic biological contaminant is virus, tumor cell, bacterium or parasite.

35. A method for eradicating a pathogenic
biological contaminant from a target body tissue, said method comprising:
admixing said target body tissue with an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof, to give a resultant body tissue;
activating said resultant body tissue with a sufficient amount of an activating agent so as to eradicate said pathogenic biological contaminant.

36. The method of claim 35 wherein said body tissue is body fluid, packed red blood cell, packed white blood cell, cryo precipitate from blood plasma, plasma protein, skin or cornea.

37. The method of claim 36 wherein said body fluid is whole blood, blood plasma, serum, fluid from plasmapheresis, bone marrow or plasma fibrinogen.

38. The method of claim 36 wherein said body fluid is albumin, gamma globulin or semen.

39. The method of claim 35 wherein said body tissue is platelet.

40. The method of claim 35 wherein said
pathogenic biological contaminant is virus, tumor cell, bacterium or parasite.

41. A method for eradicating a pathogenic
biological contaminant from a target body tissue, said method comprising:
admixing said target body tissue with an effective amount of a compound of claim 11, or a pharmaceutically acceptable salt thereof, to give a resultant body tissue;
activating said resultant body tissue with a sufficient amount of an activating agent so as to eradicate said pathogenic biological contaminant.

42. The method of claim 41 wherein said body tissue is body fluid, packed red blood cell, packed white blood cell, cryo precipitate from blood plasma, plasma protein, skin or cornea.

43. The method of claim 42 wherein said body fluid is whole blood, blood plasma, serum, fluid from plasmapheresis, bone marrow or plasma fibrinogen.

44. The method of claim 42 wherein said body fluid is albumin, gamma globulin or semen.

45. The method of claim 41 wherein said body tissue is platelet.

46.- The method of claim 41 wherein said
pathogenic biological contaminant is virus, tumor cell, bacterium or parasite.

47. A composition for cross-linking protein, which comprises an effective amount of a compound of claim 11, or an acceptable salt thereof, having been activated by a sufficient amount of an activating agent, as an active ingredient, in combination with an acceptable carrier for said active ingredient.

48. A method for eradicating a pathogenic
biological contaminant from a target body tissue, said method comprising: activating, with a sufficient amount of an
activating agent, a compound of claim 1, or a
pharmaceutically acceptable salt thereof, to give a resultant activated compound; and
admixing a sufficient amount of said resultant activated compound with said target body tissue to eradicate said pathogenic biological contaminant in said target body tissue.

49. The method of claim 48 wherein said body tissue is body fluid, packed red blood cell, packed white blood cell, cryo precipitate from blood plasma, plasma protein, skin or cornea.

50. The method of claim 49 wherein said body fluid is whole blood, blood plasma, serum, fluid from plasmapheresis, bone marrow or plasma fibrinogen.

51. The method of claim 49 wherein said body fluid is albumin, gamma globulin or semen.

52. The method of claim 48 wherein said body tissue is platelet.

53. The method of claim 48 wherein said
pathogenic biological contaminant is virus, tumor cell, bacterium or parasite.

54. A method for eradicating a pathogenic
biological contaminant from a target body tissue, said method comprising:
activating, with a sufficient amount of an
activating agent, a compound of claim 11, or a
pharmaceutically acceptable salt thereof, to give a resultant activated compound; and admixing a sufficient amount of said resultant activated compound with said target body tissue to eradicate said pathogenic biological contaminant in said target body tissue.

55. The method of claim 54 wherein said body tissue is body fluid, packed red blood cell, packed white blood cell, cryo precipitate from blood plasma, plasma protein, skin or cornea.

56. The method of claim 55 wherein said body fluid is whole blood, blood plasma, serum, fluid from plasmapheresis, bone marrow, or plasma fibrinogen.

57. The method of claim 55 wherein said body fluid is albumin, gamma globulin or semen.

58. The method of claim 54 wherein said body tissue is platelet.

59. The method of claim 54 wherein said
pathogenic biological contaminant is virus, tumor cell, bacterium or parasite.

60. A method for affixing a compound of claim 1, or its derivative, to a protein, comprising:
activating said compound of claim 1 with a
sufficient amount of an activating agent to give an activated compound; and
admixing said activated compound with said protein to affix said compound to claim 1 to said protein.

61. A method for affixing a compound of claim 11, or its derivative, to a protein, comprising:
activating said compound of claim 11 with a sufficient amount of 'an activating agent to give an activated compound; and admixing said activated compound with said protein to affix said compound to claim 11 to said protein.

62. A method for affixing a compound of claim 1, or its derivative, to a protein, comprising:
admixing an effective amount of said compound of claim 1 with said protein to give a resultant mixture; and
activating said resultant mixture with a
sufficient amount of an activating agent to affix said compound of claim 1 to said protein.

63. A method for affixing a compound of claim 11, or its derivative, to a protein, comprising:
admixing an effective amount of said compound of claim 11 with said protein to give a resultant mixture; and
activating said resultant mixture with a
sufficient amount of an activating agent to affix said compound of claim 11 to said protein.

64. A method for cross-linking a first protein to a second protein, said method comprising:
admixing said first protein and said second protein with an effective amount of a compound of claim 11, or an acceptable salt thereof, to give a resultant mixture;
activating said resultant mixture with a
sufficient amount of an activating agent to cross-link said first protein to said second protein.

65. A method for cross-linking a first protein to a second protein, said method comprising:
activating a compound of claim 11, or an
acceptable salt thereof, with a sufficient amount of an activating agent to give a resultant activated
compound; and
admixing said first protein and said second protein with an effective amount of said activated compound to cross-link said first protein to said second protein.

66. A method of preparing a vaccine comprising:
admixing a suspension of a virus in a suitable carrier with an effective amount of a compound of claim 1 to give a resultant mixture; and
activating said resultant mixture with a
sufficient amount of an activating agent to cause damage to said virus.

67. The method according to claim 66, wherein said suitable carrier comprises aqueous buffer.

68. A vaccine prepared in accordance with the method of claim 66.

69. A method of preparing a vaccine comprising:
admixing a suspension of a virus in a suitable carrier with an effective amount of a compound of claim 11 to give a resultant mixture; and
activating said resultant mixture with a
sufficient amount of an activating agent to cause damage to said virus.

70. The method according to claim 69, wherein said suitable carrier comprises aqueous buffer.

71. A vaccine prepared in accordance with the method of claim 69.

72. A method of preparing a vaccine comprising: admixing a suspension of a bacterium in a suitable carrier with an effective amount of a compound of claim

1 to give a resultant mixture; and
activating said resultant mixture with a
sufficient amount of an activating agent to cause damage to said bacterium.

73. The method according to claim 72, wherein said suitable carrier comprises aqueous buffer.

74. A vaccine prepared in accordance with the method of claim 72.

75. A method of preparing a vaccine comprising:
admixing a suspension of a bacterium in a suitable carrier with an effective amount of a compound of claim

II to give a resultant mixture; and
activating said resultant mixture with a
sufficient amount of an activating agent to cause damage to said bacterium.

76. The method of claim 75, wherein said suitable carrier comprises aqueous buffer.

77. A vaccine prepared in accordance with the method of claim 75.

78. A method of preparing a vaccine comprising:
activating a compound of claim 1 with a sufficient amount of activating agent to give a resultant mixture; and
admixing said resultant mixture with a virus in a suitable carrier to cause damage to said virus.

79. The method of claim 78, wherein said suitable carrier comprises aqueous buffer.

80. A vaccine prepared in accordance with the method of claim 78.

81. A method of preparing a vaccine comprising:
activating a compound of claim 11 with a
sufficient amount of activating agent to give a
resultant mixture; and
admixing said resultant mixture with a virus in a suitable carrier to cause damage to said virus.

82. The method of claim 81, wherein said suitable carrier comprises aqueous buffer.

83. A vaccine prepared in accordance with the method of claim 81.

84. A method of preparing a vaccine comprising:
activating a compound of claim 1 with a sufficient amount of activating agent to give a resultant mixture; and
admixing said resultant mixture with a bacterium in a suitable carrier to cause damage to said
bacterium.

85. The method of claim 84, wherein said suitable carrier comprises aqueous buffer.

86. A vaccine prepared in accordance with the method of claim 84.

87. A method of preparing a vaccine comprising:
activating a compound of claim 11 with a
sufficient amount of activating agent to give a
resultant mixture; and
admixing said resultant mixture with a bacterium in a suitable carrier to cause damage to said
bacterium.

88. The method of claim 87, wherein said suitable carrier comprises aqueous buffer.

89. A vaccine prepared in accordance with the method of claim 87.

90. A method of bonding a first body tissue to a second body tissue, comprising:
coating a surface of each of said first and said second body tissue with a sufficient amount of a compound of claim 11 to give a first coated body tissue and a second coated body tissue;
placing said first coated body tissue and said second coated body tissue in close proximity to give a resultant mixture;
activating said resultant mixture with a
sufficient amount of an activating agent to bond said first and said second body tissue.

91. A method claim 90, wherein said first tissue is tendon, ligament, cornea, skin, arterial wall, venous wall, fallopian tube, vas deferens, or nerve sheath.

92. A method claim 90, wherein said second tissue is tendon, ligament, cornea, skin, arterial wall, venous wall, fallopian tube, vas deferens, or nerve sheath.

93. A bonded tissue, comprising at least two tissues, prepared in accordance with the method of claim 90.

94. A method of bonding a first body tissue to a second body tissue, comprising: activating a compound of claim 11 with a
sufficient amount of activating agent to give an activated compound;
mixing said activated compound with a surface of each of said first and said second body tissue with an effective amount of said activated compound to bond said first body tissue to said second body tissue.

95. The method of claim 94, wherein said first tissue is tendon, ligament, cornea, skin, arterial wall, venous wall, fallopian tube, vas deferens, or nerve sheath.

96. The method of claim 94, wherein said second tissue is tendon, ligament, cornea, skin, arterial wall, venous wall, fallopian tube, vas deferens, or nerve sheath.

97. A bonded tissue, comprising at least two tissues, prepared in accordance with the method of claim 94.