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1. WO1993018070 - COMPOSES CHIMIQUES

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]

Claims

1. Biodegradable non-crosslinked polymers of low or zero water-solubility comprising a non-polypeptide polymer backbone carrying side chains, at least a proportion of the said side chains containing lipophilic moieties bonded to the polymer backbone by way of methylene diester units of formula (I)



(where R1 and R2, which may be the same or different, each represent a hydrogen atom or a carbon-attached monovalent organic group or R1 and R2 together form a carbon-attached divalent organic group) , whereby the said lipophilic moieties are biodegradatively cleavable to yield a water-soluble polymer.

2. Polymers as claimed in claim 1 containing units of formula (II)



(where A represents a repeating unit of a nonpolypeptide polymer backbone chain; L represents a linking group; 1, m and n, which may be the same or different, are each zero or 1; R1 and R2 are as defined in claim 1 and R3 represents a lipophilic organic group)

3. Polymers as claimed in claim 2 wherien the
repeating units A and any comonomer units contain 1-6 carbon atoms optionally interrupted by one or more heteroatoms selected from oxygen, nitrogen and sulphur and/or substituted by one or more substituents
comprising such heteroatoms.

4. Polymers as claimed in claim 3 wherein A represents ethylene or propylene.

5. Polymers as claimed in any of claims 2 to 4 wherein L is a C1-3 alkylene group optionally terminating in and/ or interrupted by one or more oxy, carbonyl,
oxycarbonyl, imino or iminocarbonyl groups.

6. Polymers as claimed in any of the preceding claims which are biodegradable to yield a water-soluble
polyvinyl alcohol, polyacrylic acid, polymethacrylic acid, polyhydroxyalkyl acrylate or methacrylate,
polysaccharide, polyester, polyether, polyamide,
polyurethane or epoxy polymer.

7. Polymers as claimed in any of claims 2 to 6 wherein R1 and R2 (when other than hydrogen) and R3 are selected from aliphatic groups having up to 10 carbon atoms, cycloalkyl groups having up to 10 carbon atoms,
araliphatic groups having up to 20 carbon atoms, aryl groups having up to 20 carbon atoms, heterocyclic groups having up to 20 carbon atoms and one or more heteroatoms selected from oxygen, sulphur and nitrogen, and any of the preceding groups carrying one or more functional substituents and/or, in the case of R3, interrupted and/or terminated by a heteroatom selected from oxygen, nitrogen and sulphur.

8. Polymers as claimed in claim 7 wherein R1 and R2 are each selected from hydrogen atoms and C1-4 alkyl groups and R3 is selected from lower alkyl, phenyl and phenyl lower alkyl.

9. Polymers as claimed in any of the preceding claims in the form of surgical implants, soft tissue
prostheses, sponges, films, wound dressings, flexible sheets, containers and delayed release formulations for drugs and agricultural chemicals, particulate imaging agents or plasticisers.

10. A process for the preparation of a polymer as claimed in claim 1 which comprises either (A) reaction of a preformed water-soluble polymer with a reagent serving to introduce the desired lipophilic methylene diester side chain or (B) polymerisation of a functional monomer which carries the desired lipophilic methylene diester side chain.

11. A process according to (B) of claim 10 wherein free radical polymerisation is effected.