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1. (WO1993016729) ANTICORPS POUR LA PREVENTION OU L'ATTENULATION DE LA GRAVITE DU REJET D'UNE XENOGREFFE
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WHAT IS CLAIMED IS:
1. A process for preventing or reducing the severity of xenograft rejection in a patient, comprising:
reducing levels of natural antibodies which are
xenoreactive by contact with an effective amount of at least one anti-human IgM.
2. The process of Claim 1 wherein the antibody is contacted with blood of the patient in vivo.
3. The process of Claim 1 wherein the antibody is contacted with blood of the patient in vitro.
4. The process of Claim 1 wherein the antibody is anti-human mu chain antibody.
5. The process of Claim 4 wherein the antibody is a monoclonal antibody .
6. The process of Claim 5 wherein the antibody is used in vivo in an amount of at least 25 mg.
7. The process of Claim 5 wherein the antibody is administered to a patient over a period of days.
8. A process for removing or neutralizing natural human antibodies which are immunoreactive with antigens from a non-human species, comprising:
contacting the natural human antibodies with at least one anti-human IgM antibody in an amount effective to effect neutralization or removal thereof.
9. The process of Claim 7 wherein said natural antibodies are present in blood.
10. A process for preventing or reducing the severity of ABO incompatible allograft rejection in a patient, comprising:
reducing levels of natural antibodies which are alloreactive by contact with at least one anti-human IgM.