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1. (WO1993016686) PREPARATION PHARMACEUTIQUE PERMETTANT LA LIBERATION PROLONGEE D'UN MEDICAMENT, ET PROCEDE DE PRODUCTION
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

CLAIMS
1. A polymer matrix type pharmaceutical preparation for sustained release of a drug which comprises as a main base hydroxypropylmethylcellulose, wherein the drag is released according to the following formula:

( a ) in the case where V ι C s> A


( b ) in the case where V ι C s<^ A ,


( c ) in the case where V , C S< A ,



wherein Cs is the solubility of the drag, A is the total amount of the drag present in the unit volume of the matrix, Vj is the effective volume in the interior of the matrix, Oj is the drug releasing amount after t hours, Sq is the total surface area, D is the diffusion coefficient of the drag in the matrix, τ is the tortuosity in the capillary tube system, Q, is the total drag releasing amount, Q0 is the amount of the drag contained in one pharmaceutical preparation, k2 is the apparent rate constant for releasing the drag from a drug granule.

2. The pharmaceutical preparation for sustained release of a drag according to . claim 1, wherein the drag is adinazolam methanesulfonate, alprazolam or triazolam.

3. A process for producing a pharmaceutical preparation for sustained release of drag which comprises wet-granulating a drag using a binder, and drying it to obtain a granule, mixing the granule with hydroxypropylmethylcellulose and a water-soluble ingredient, then compressing it to obtain a polymer matrix type pharmaceutical preparation for sustained release of a drug comprising as a main base hydroxypropylmethylcellulose so that the drag is released according to the following formula:

Ca) in the case where VιCs>A,

( b ) in the case where V,CS<A,


( c ) in the case where V , C s< A ,

Qt = Q. (1 -(1 -k, t T3}

wherein Cs is the solubility of the drag, A is the total amount of the drag present in the unit volume of the matrix, Vr is the effective volume in the interior of the matrix, Q, is the drag releasing amount after t hours, Sq is the total surface area, D is the diffusion coefficient of the drag in the matrix, τ is tortuosity of the capillary tube system, Qt is the total drug releasing amount, Q,, is the amount of the drag contained in one preparation, l is the apparent rate constant for releasing the drag from a drug granule.