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1. (WO1993016658) UTILISATION DE MATIERES BIOLOGIQUES INJECTABLES DANS LA REPARATION ET LE RENFORCEMENT DES SPHINCTERS DE L'ANUS
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

WHAT IS CLAIMED IS:
1. A method of repairing structurally defective or inadequately functioning muscles of the anal sphincters
comprising administering an effective amount of an injectable

5 biomaterial perianally into the defect or structural deformity.

2. The method of Claim 1 wherein said injectable biomaterial is atelopeptide fibrillar, crosslinked or non- crosslinked collagen.
IC
3. The method of Claim 1 wherein said injectable biomaterial is an aqueous suspension of a biopolymer with a
biocompatible fluid lubricant.

15 4. The method of Claim 3 wherein said biopolymer is selected from the group consisting of: atelopeptide
fibrillar, crosslinked or non-crosslinked collagen, gelatin
beads, polytetrafluoroethylene beads, silicone rubber beads, hydrogel beads, silicon carbide beads, and glass beads.
20
5. The method of Claim 3 wherein said
biocompatible fluid lubricant is selected from the group
consisting of: hyaluronic acid, dextran sulfate, dextran,
succinylated non-crosslinked collagen, methylated non-25 crosslinked collagen, glycogen, glycerol, dextrose, maltose, triglycerides of fatty acids, egg yolk phospholipids, and
heparin.

6. The method of Claim 1 wherein said injectable 30 biomaterial is a second nucleation collagen.

7. The method of Claim 2 wherein said collagen is conjugated to a chemically activated polymer.

35 8. The method of Claim 7 wherein said chemically activated polymer is polyethylene glycol.

9. The method of Claim 2 wherein said collagen is crosslinked with a bifunctional activated polymer.

10. The method of Claim 9 wherein said collagen and said bifunctional activated polymer crosslink in situ.

11. The method of Claim 9 wherein said bifunctional activated polymer is polyethylene glycol.

12. The method of Claim 2 wherein said biomaterial further comprises a ceramic and/or mineral material.

13. The method of claim 12 wherein said ceramic material comprises ceramic particles in the size range of about 50-250 microns.

14. The method of Claim 1 wherein said biomaterial further comprises one or more wound healing agents.

15. The method of Claim 14 wherein said wound healing agent is selected from the group consisting of:
fibroblast growth factors (FGFs) , platelet derived growth factors (PDGFs) , epidermal growth factors (EGFs) , connective tissue activating peptides (CTAPs) , and transforming growth factors (TGFs) , and biologically active analogs, derivatives, or fragments thereof.

16. The method of Claim 1 wherein said biomaterial further comprises an antimicrobial additive and/or antibiotic.

17. A method of improving the competency of
incompetent anal sphincters comprising administering an effective amount of an injectable biomaterial into the anal sinuses between the blood vessels.

18. The method of Claim 17 wherein said injectable biomaterial is atelopeptide fibrillar, crosslinked or non- crosslinked collagen.

5 19. The method of Claim 17 wherein said injectable biomaterial is an aqueous suspension of a biopolymer with a
biocompatible fluid lubricant.

20. The method of claim 19 wherein said biopolymer IC it selected from the group consisting of: atelopeptide
fibrillar, crosslinked or non-crosslinked collagen, gelatin
beads, polytetrafluoroethylene beads, silicone rubber beads, hydrogen beads, silicon carbide beads, and glass beads.

15 21. The method of Claim 19 wherein said
biocompatible fluid lubricant is selected from the group
consisting of: hyaluronic acid, dextran sulfate, dextran,
succinylated non-crosslinked collagen, methylated non- crosslinked collagen, glycogen, glycerol, dextrose, maltose,

20 triglycerides of fatty acids, egg yolk phospholipids, and
heparin.

22. The method of Claim 17, wherein said injectable biomaterial is a second nucleation collagen.
25
23. The method of Claim 18 wherein said collagen is conjugated to a chemically activated polymer.

24. The method of Claim 23 wherein said chemically 30 activated polymer is polyethylene glycol.

25. The method of Claim 18 wherein said collagen is crosslinked with a bifunctional activated polymer.

35 26. The method of Claim 25 wherein said collagen and said bifunctional activated polymer crosslink in situ.

27. The method of Claim 25 wherein said
bifunctional activated polymer is polyethylene glycol.

28. The method of Claim 18 wherein said biomaterial further comprises a ceramic and/or mineral material.

29. The method of Claim 28 wherein said ceramic material comprises ceramic particles in the size range of about 50 - 250 microns.

30. The method of Claim 17 wherein said biomaterial further comprises an antimicrobial additive and/or antibiotic.

31. A method of inducing wound healing of a
structurally defective anal sphincter comprising administering an effective amount of an injectable biomaterial, containing one or more wound healing agents, into the defect.

32. The method of Claim 31 wherein said injectable biomaterial is atelopeptide fibrillar, crosslinked or non-crosslinked collagen.

33. The method of Claim 31 wherein said injectable biomaterial is an aqueous suspension of a biopolymer with a biocompatible fluid lubricant.

34. The method of Claim 33 wherein said biopolymer is selected from the group consisting of: atelopeptide
fibrillar, crosslinked or non-crosslinked collagen, gelatin beads, polytetrafluoroethylene beads, silicone rubber beads, hydrogel beads, silicon carbide beads, and glass beads.

35. The method of Claim 33 wherein said
biocompatible fluid lubricant is selected from the group consisting of: hyaluronic acid, dextran sulfate, dextran, succinylated non-crosslinked collagen, methylated non-crosslinked collagen, glycogen, glycerol, dextrose, maltose, triglycerides of fatty acids, egg yolk phospholipids, and heparin.

36. The method of Claim 31 wherein said injectable biomaterial is a second nucleation collagen.

37. The method of Claim 32 wherein said collagen is conjugated to a chemically activated polymer.

38. The method of Claim 37 wherein said chemically activated polymer is polyethylene glycol.

39. The method of Claim 32 wherein said collagen is crosslinked with a bifunctional activated polymer.

40. The method of Claim 39 wherein said collagen and said bifunctional activated polymer crosslink in situ.

41. The method of Claim 39 wherein said
bifunctional activated polymer is polyethylene glycol.

42. The method of Claim 31 wherein said biomaterial further comprises a ceramic and/or mineral material.

43. The method of Claim 42 wherein said ceramic material comprises ceramic particles in the size range of about 50 - 250 microns.

44. The method of Claim 31 wherein said wound healing agent is selected from the group consisting of:
fibroblast growth factors (FGFs) , platelet derived growth factors (PDGFs) , epidermal growth factors (EGFs) , connective tissue activating peptides (CTAPs) , or transforming growth factors (TGFs) , and biologically active analogs, derivatives, or fragments thereof.

45. The method of Claim 31 wherein said biomaterial further comprises an antimicrobial additive and/or antibiotic.