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1. WO1992017165 - SYSTEME DE VACCINATION PAR DOSE UNIQUE

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Claims
1. A pharmaceutical or veterinary implant, which when parenterally administered releases a pulse of at least one biologically active material at a controllable time interval after implantation, said implant comprising:
a) the biologically active material;
b) an excipient comprising at least one water soluble material and at least one water insoluble material; and
c) a polymer film coating adapted to rupture at a predetermined period of time after implantation,
wherein the excipients and polymers are
biocompatible.
2. An implant according to Claim 1, in which the biologically active material is selected from the group consisting of antigens, antibodies, hormones, growth promotants, antibiotics, nutrients, minerals and vitamins.

3. An implant according to Claim 1 or Claim 2, in which the excipient comprises a combination of two or more water-soluble and water-insoluble materials.
4. An implant according to Claim 3, in which the water-insoluble material is swellable.
5. An implant according to any one of Claims 1 to 4, wherein two different polymer films are applied to a compressed core, and said polymer films are:
i) a bilayer coating comprising an insoluble biocompatible film and ah enteric (pH sensitive) polymer, and
ii) a single film comprising a mixture of insoluble and biodegradable polymer.
6. An implant according to any one of the preceding claims, in which the coating comprises a mixture of water insoluble and bioerodable polymers.
7. A pharmaceutical or veterinary implant which when parenterally administered releases a biologically active material in a delayed pulsed release manner, wherein the implant comprises the active material and excipients as a compressed or moulded core encased within a polymeric coating which degrades sufficiently after a period of time to release the active material, and wherein all of the implant components are biocompatible.
8. A combined pharmaceutical or veterinary implant comprising an implant according to any one of the preceding claims, together with an implant which when parenterally administered releases the same or a different biologically active material with substantially no delay.
9. An implant according to any one of the preceding claims in which the biologically active material is an antigen.
10. An implant according to Claim 9, which
additionally comprises an immunologically active adjuvant.

11. An implant according to Claim 9 or Claim 10 wherein the antigen is selected from the group consisting of caseous lymphadenitis toxoid, Clostridium botulinum toxoid, tetanus toxoid, and luteinizing hormone releasing hormone.
12. An implant according to any one of Claims 1 to 8 wherein the biologically active material is a hormone, a vitamin or a growth promotant.
13. A method of administration of a biologically active material to a mammal, comprising the step of
implanting into said mammal an implant according to any one of the preceding claims.