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1. WO1991016058 - COMPOSITION ET PROCEDE DE TRAITEMENT LOCAL DE TISSUS ABIMES OU MALADES

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CLAIMS

1. A composition for topically treating damaged or diseased tissue comprising a solution of:
a. a polyoxyethylene-polyoxypropylene block copolymer having the following formula:

HO(C H O) (C H O) (C H O) H
2 4 b 3 6 a 2 4 b
wherein a is an integer such that the hydrophobe represented by C3H6O has a molecular weight of between 2250 and 6000 daltons and b is an integer such that the hydrophile portion represented by C2H4O constitutes from about 50 to 90 percent by weight of the copolymer, and
b . an effective amount of dermatan sulfate.

2. The composition of Claim 1, wherein the hydrophobe represented by C3H6O has an average molecular weight of between approximately 2750 and 4000 daltons.

3. The composition of Claim 2, wherein the hydrophobe represented by C3H6O has an average molecular weight of approximately 4000 daltons.

4. The composition of Claim 1, further comprising an antimicrobial compound.

5. The composition of Claim 4, wherein the antimicrobial compound is an antibacterial compound.

6. The composition of Claim 4, wherein the antimicrobial compound is an antifungal compound.

7. The composition of Claim 1 , further comprising an anti-inflammatory agent.

8. The composition of Claim 1, further comprising a growth factor.

9. The composition of Claim 1, further comprising an anesthetic.

10. A method of treating damaged tissue in a human or animal comprising the step of topically administering to the human or animal with diseased or damaged tissue an aqueous solution containing:
a. a polyoxyethylene-polyoxypropylene block copolymer having
the following formula:

HO(C H O) (C H O) (C H O) H
v 2 4 V 3 6 a 2 4 'b
wherein a is an integer such that the hydrophobe represented
by C3H6O has a molecular weight of between 2250 and 6000
daltons and b is an integer such that the hydrophile portion
represented by C2H4O constitutes from about 50 to 90
percent by weight of the copolymer, and
b . an effective amount of an acid mucopolysaccharide.

11. The method of Claim 10, wherein the acid mucopolysaccharide is selected from the group consisting of heparin, heparan sulfate, heparinoids, dermatan sulfate, pentosan polysulfate, chondroitan sulfate and hyaluronic acid.
- 12. The method of Claim 11 , wherein the acid mucopolysaccharide is heparin.

13. The method of Claim 11, wherein the acid mucopolysaccharide is dermatan sulfate.

14. The method of Claim 10, wherein the acid mucopolysaccharide is has minimal anticoagulant activity.

15. The method of Claim 10, wherein the hydrophobe represented by C3H6O has an average molecular weight of between approximately 2750 and 4000 daltons.

16. The method of Claim 15 wherein the hydrophobe represented by C3H6O has an average molecular weight of approximately 4000 daltons.

17. The method of Claim 10, wherein the composition further comprises an antimicrobial compound.

18. The method of Claim 17, wherein the antimicrobial compound is an antibacterial compound.

19. The method of Claim 17, wherein the antimicrobial compound is an antifungal compound.

20. The method of Claim 10, wherein the composition further comprises an anti-inflammatory agent.

21. The method of Claim 10, wherein the composition further comprises an anesthetic.

22. A method of treating burns in a human or animal comprising the step of topically administering to the human or animal with the bu a composition comprising
a. a polyoxyethylene-polyoxypropylene block copolymer having the following formula:

HO(C H O) (C H O) (C H O) H
2 4 V 3 6 a 2 4 'b
wherein a is an integer such that the hydrophobe represented by C3H6O has a molecular weight of between 2250 and 6000 daltons and b is an integer such that the hydrophile portion represented by C2H4O constitutes from about 50 to 90 percent by weight of the copolymer, and
b . an effective amount of an acid mucopolysaccharide.

23. The method of Claim 22, wherein the acid mucopolysaccharide is selected from the group consisting of heparin, heparin sulfate, heparinoids, low molecular weight heparin, dermatan sulfate, pentosan polysulfate, chondroitan sulfate and hyaluronic acid.

24. The method of Claim 23, wherein the acid mucopolysaccharide is heparin.

25. The method of Claim 27, wherein the acid mucopolysaccharide is dermatan sulfate.

26. The method of Claim 22, wherein the acid mucopolysaccharide is has minimal anticoagulant activity.

27. The method of Claim 22, wherein the hydrophobe represented by C3H6O has an average molecular weight of between approximately 2750 and 4000 daltons.

28. The method of Claim 27, wherein the hydrophobe represented by C3H6O has an average molecular weight of approximately 4000 daltons.

29. The method of Claim 22, wherein the composition further comprises an antimicrobial compound.

30. The method of Claim 29, wherein the antimicrobial compound is an antibacterial compound.

31. The method of Claim 29, wherein the antimicrobial compound is an antifungal compound.

32. The method of Claim 22, wherein the composition further comprises an anti-inflammatory agent.

33. The method of Claim 22, further comprising an anesthetic.