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1. WO1989005140 - AGENTS ET PROCEDE DE CIBLAGE DE TUMEURS

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

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CLAIMS

1. A tumour-targeting agent comprising a compound of mean molecular weight no more than about 70,000 that can become bound to a characteristic reactive site on a tumour cell, and that has a ligand comprising an attachment portion capable of becoming reversibly bound to a complementary binding protein so as to form a .complex with said binding protein.

2. A tumour-targeting agent according to claim 1 in which the compound is of mean molecular weight of no more than about 50,000.

3. A tumour-targeting agent according to claim 1 in which the compound is of mean molecular- weight of no more than about 10,000.

4. A tumour-targeting agent according to claim 1 in which the compound is of mean molecular weight of no more than about 5,000.

5. A tumour-targeting agent according to any one of claims 1 to 4 in which the compound incorporates a radioactive element.

6. A tumour-targeting agent according to any one of claims 1 to 4 in which the compound incorporates a chemotherapeutic constituent.

7. A tumour-targeting agent according to any one of the preceding claims in which the compound incorporates an antibody fragment capable of becoming bound to a characteristic reactive site on a tumour cell.

8. A tumour-targeting agent according to any one of the preceding claims in which the ligand comprises thyroxine or a non-functional thyroxine analogue.

9. A tumour-locating agent comprising a complex constituting a compound in accordance with any one of the preceding claims and a complementary binding protein .

10. A tumour-locating agent substantially as hereinbefore described in the Example .

11. A method of employing a tumour-targeting agent in accordance with any one of the preceding claims , in which method a quantity of the. agent is introduced into the bloodstream of a living human being or animal.

12. A method according to claim 11 in which a period of time is allowed to elapse sufficient to enable at least some of any tumour cells present to become characterised by the fact that each such cell has many more molecules of the compound bound to it than there are molecules of the compound bound to an average normal cell, or the concentration of the compound bound to at least some of tumour cells is significantly greater than the concentration elsewhere in the human being or animal .

13. A method according to claim 12 in which, after that period of time, a substance is introduced into the bloodstream which competes with said compound for becoming bound to said complementary binding protein, whereby the rate at which said compound is eliminated from the bloodstream is increased.